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General Information
Symbol
Dmel\Gαo007
Species
D. melanogaster
Name
FlyBase ID
FBal0098391
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
bkh007
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Imprecise excision of the P{lacW} element, resulting in a deletion of 839bp which removes 3 potential TATA boxes together with 311bp of the 5' end of the G-oα47A class II transcription unit.
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
G-oα47A007 wing somatic clones exhibit mutant margin bristles. G-oα47A007 thoracic mutant clones exhibit bald regions with surviving bristles displaying polarity defects. Defects, due to aberrations in asymmetric division, including the absence of external cells, duplicated sockets and/or hairs, and bristles devoid of sockets or hairs are observed in G-oα47A007 mutant clones. Approximately 8% of G-oα47A007 bristles exhibit hair/socket duplications. Socket-only phenotypes occur in 5% of cases.
Only late induced somatic clones survive into the adult. Although homozygous early induced clones in the wing do not survive to the adult stage, clear polarity defects are seen in these wings in the adult, likely as a result of nonautonomous effects of clones that subsequently died. Homozygous late induced clones in the wing induce the loss of wing margin. In addition, these late induced clones often secrete multiple wing hairs, with up to five hairs per cell. These clones often cause nonautonomous defects on their proximal side. In addition, clones in the wing margin also result in nonautonomous defects in wing margin bristle polarity on the proximal side of the clone.
Homozygous embryos have defects in the heart and visceral muscles. Interruptions are seen in the dorsal vessel. Cardial cells are present and migrate properly to a dorsal position, but in some places they are not arranged as a continuous layer but appear as unorganised clusters of cells. The same types of defects are seen in the visceral mesoderm. Longitudinal axons of the nervous system are often pinched or sometimes missing and the axons of motoneurons are clearly misrouted.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
G-oα47A007/+ ; oa21/+ double heterozygous third instar larvae show a significant increase in the number of natural synaptopods (motile filopodia-like extensions) and type II boutons at the type II neuromuscular junction compared to wild type. The number of type I boutons at the neuromuscular junction is also increased in these animals.
G-oα47A007 heterozygotes in a G-iα65Aunspecified homozygous background exhibit adult bristle defects that are not present in G-iα65Aunspecified homozygotes.
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Partially rescued by
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (7)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (6)