Co-expression of Hsap\LRRK2G2019S.Scer\UAS.cLa.T:Zzzz\FLAG strongly enhances the dendrite defects caused by Scer\GAL4109(2)80>Avic\GFPScer\UAS.S65T.I167T.T:Btau\MAPT. In severe cases, only six of the eight dendritic arborization (DA) neuron somas are present in the dorsal field, an indication of neuronal loss that is not detected when Hsap\LRRK2G2019S.Scer\UAS.cLa.T:Zzzz\FLAG or Avic\GFPScer\UAS.S65T.I167T.T:Btau\MAPT is expressed alone.
Co-expression of Hsap\LRRK2G2019S.Scer\UAS.cLa.T:Zzzz\FLAG enhances the formation of spheroid inclusions caused by Scer\GAL4ppk.PG>Avic\GFPScer\UAS.S65T.I167T.T:Btau\MAPT-expression. The spheroid inclusions appear much more frequent in both distal and proximal dendrites when Hsap\LRRK2G2019S.Scer\UAS.cLa.T:Zzzz\FLAG is also expressed.
Lrrke03680/+ partially suppresses the dendrite degeneration phenotype resulting from the expression of Scer\GAL4109(2)80>Avic\GFPScer\UAS.S65T.I167T.T:Btau\MAPT. Dendrites of the Avic\GFPScer\UAS.S65T.I167T.T:Btau\MAPT-expressing neurons are longer and the number of dendritic ends is increased. The suppression by Lrrke03680/+ is also observed in inclusion formation and microtubule fragmentation.