Allele Dmel\tgo⁵

General Information
Symbol	Dmel\tgo⁵	Species	D. melanogaster
Name		FlyBase ID	FBal0098639
Feature type	allele	Associated gene	Dmel\tgo

Map ( GBrowse )
Allele class
Mutagen
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen
Mutations Mapped to the Genome

Type Location Additional Notes References point mutation 3R:4,844,003..4,844,003 na_change=C4844003T reported_na_change=C?T pr_change=Q468@ \| tgo-PA reported_pr_change=Q468@ (Tajiri et al., 2007)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Cytology
Phenotypic Data
Phenotypic Class
	visible \| recessive \| somatic clone (Emmons et al., 1999)
Phenotype Manifest In
	antenna \| somatic clone (Emmons et al., 1999) arista \| somatic clone (Emmons et al., 1999) basal cylinder \| somatic clone (Emmons et al., 1999) leg \| distal \| somatic clone (Emmons et al., 1999) macrochaeta \| somatic clone (Emmons et al., 1999) maxillary palpus \| somatic clone (Emmons et al., 1999) presumptive embryonic/larval tracheal system (Lavista-Llanos et al., 2002) tarsal segment 2 \| somatic clone (Emmons et al., 1999) tarsal segment 3 \| somatic clone (Emmons et al., 1999) tarsal segment 4 \| somatic clone (Emmons et al., 1999) third segment of antenna \| distal \| somatic clone (Emmons et al., 1999) unguis \| ectopic \| somatic clone (Emmons et al., 1999) wing \| somatic clone (Emmons et al., 1999)
Detailed Description
	Statement Reference tgo⁵ clones (generated using the MARCM technique) of the ddaD and ddaC neurons do not show any obvious dendritic defects. (Kim et al., 2006) Mutant embryos have tracheal defects. (Lavista-Llanos et al., 2002) Close to a null allele. Homozygous clones have no effect in the proximal antennal segments (segments 1 and 2). Clones transform the distal part of antennal segment 3, the basal cylinder and arista to a tarsus that is deleted for most of its segments. Arista-claw intermediates are often present, and the identity of the proximal part of antennal segment 3 is unaffected. Homozygous clones in the distal part of the leg often show pattern deletions that include the second through fourth tarsal segments. Clones in the proximal part of the leg have no effect. Homozygous clones in the maxillary palps result in distal deletions. Homozygous clones in the wing hinge region cause the wing to be held out away from the body. Homozygous clones show a strong reduction in bristle size. Homozygous clones in the proboscis, vibrissae, dorsal head, dorsal thorax, wings and abdomen appear normal, with the exception of a reduction in bristle size. (Emmons et al., 1999)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressor of
Statement Reference tgo[+]/tgo⁵ is a suppressor \| partially of female germline stem cell phenotype of piwi² (Smulders-Srinivasan and Lin, 2003)
Other
Statement Reference Df(3R)ss-D114.4/+, tgo⁵ has arista phenotype (Emmons et al., 1999) Df(3R)ss-D114.4/+, tgo⁵ has basal cylinder phenotype (Emmons et al., 1999) Df(3R)ss-D114.4/+, tgo⁵ has third segment of antenna phenotype (Emmons et al., 1999)
Additional Comments
Genetic Interactions
Statement Reference Dominant enhancer of the Df(3R)ss-D114.4/+ weak antenna to tarsus transformation phenotype. The antennae from Df(3R)ss-D114.4/tgo⁵ heterozygotes have a swelling at the base of the arista and bracted bristles on the basal cylinder and the distal part of antennal segment 3. (Emmons et al., 1999)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Fails to complement	tgo¹ (Emmons et al., 1999) tgo² (Emmons et al., 1999) tgo³ (Emmons et al., 1999) tgo⁶ (Emmons et al., 1999) tgo⁷ (Emmons et al., 1999)
Comments
Stocks ( 1 )
Bloomington	9589 P{neoFRT}82B tgo⁵/TM1
Notes on Origin
Discoverer
	Selected as: a dominant enhancer of the Df(3R)ss-D114.4/+ weak antenna to tarsus transformation phenotype. (Emmons et al., 1999)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	tgo⁵ (Kozu et al., 2006, Kim et al., 2006)
Name Synonym
Secondary FlyBase IDs

References ( 6 )
Research paper	Tajiri et al., 2007, Dev. Biol. 303(2): 461--473 Fate determination of Drosophila leg distal regions by trachealess and tango through repression and stimulation, respectively, of Bar homeobox gene expression in the future pretarsus and tarsus. [FBrf0201052] Kim et al., 2006, Genes Dev. 20(20): 2806--2819 The bHLH-PAS protein Spineless is necessary for the diversification of dendrite morphology of Drosophila dendritic arborization neurons. [FBrf0195191] Kozu et al., 2006, Dev. Biol. 294(2): 497--508 Temporal regulation of late expression of Bar homeobox genes during Drosophila leg development by Spineless, a homolog of the mammalian dioxin receptor. [FBrf0194671] Smulders-Srinivasan and Lin, 2003, Genetics 165(4): 1971--1991 Screens for piwi suppressors in Drosophila identify dosage-dependent regulators of germline stem cell division. [FBrf0167655] Lavista-Llanos et al., 2002, Molec. Cell. Biol. 22(19): 6842--6853 Control of the hypoxic response in Drosophila melanogaster by the basic helix-loop-helix PAS protein Similar. [FBrf0152214] Emmons et al., 1999, Development 126(17): 3937--3945 The spineless-aristapedia and tango bHLH-PAS proteins interact to control antennal and tarsal development in Drosophila. [FBrf0109662]

Allele Dmel\tgo5

Allele Dmel\tgo⁵