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General Information
Symbol
Dmel\mei-41unspecified
Species
D. melanogaster
Name
FlyBase ID
FBal0098697
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference
    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    The wing discs of mei-41unspecified mutant third instar larvae exhibit similar levels of apoptosis to controls in response to X-ray induced irradiation. As in controls, very little apoptosis is seen in the absence of irradiation.

    Mutants can be recombination defective. Mutants can show sensitivity to methyl methanesulfonate, nitrogen mustard, UV light, γ rays or X rays. Mutants are not defective in repair of single strand breaks or excision repair, but can be defective in post-replication repair.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    NOT Enhancer of
    Statement
    Reference

    mei-41unspecified is a non-enhancer of visible phenotype of Wee1GMR.PP

    mei-41unspecified is a non-enhancer of visible phenotype of Myt1GMR.PP

    NOT Suppressor of
    Statement
    Reference

    mei-41unspecified is a non-suppressor of visible phenotype of Wee1GMR.PP

    mei-41unspecified is a non-suppressor of visible phenotype of Myt1GMR.PP

    Other
    Phenotype Manifest In
    NOT Enhancer of
    Statement
    Reference

    mei-41unspecified is a non-enhancer of eye phenotype of Wee1GMR.PP

    mei-41unspecified is a non-enhancer of eye phenotype of Myt1GMR.PP

    Suppressor of
    NOT Suppressor of
    Statement
    Reference

    mei-41unspecified is a non-suppressor of chorion phenotype of cuffunspecified

    mei-41unspecified is a non-suppressor of ovary phenotype of CSN5unspecified

    mei-41unspecified is a non-suppressor of eye phenotype of Myt1GMR.PP

    mei-41unspecified is a non-suppressor of eye phenotype of Wee1GMR.PP

    Other
    Additional Comments
    Genetic Interactions
    Statement
    Reference

    mei-41unspecified; wtsx1/+ flies show a higher tumor incidence than controls, with a 2-fold increase at baseline and >10-fold increase after treatment with ionizing radiation.

    mei-41unspecified tefuunspecified double mutant third instar larvae usually have melanotic tumours.

    The eggshell defects seen in eggs derived from homozygous spn-D1 or spn-D1/spn-D2 females are suppressed if the females also carry mei-41unspecified.

    The ovary phenotype of CSN5unspecified mutants is not suppressed by mei-41unspecified.

    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Comments
    Images (0)
    Mutant
    Wild-type
    Stocks (0)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (2)
    Reported As
    Symbol Synonym
    mei-41unspecified
    Name Synonyms
    Secondary FlyBase IDs
      References (14)