FB2025_01 , released February 20, 2025
Allele: Dmel\mei-41unspecified
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General Information
Symbol
Dmel\mei-41unspecified
Species
D. melanogaster
Name
FlyBase ID
FBal0098697
Feature type
allele
Associated gene
Dmel\mei-41
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 1 )
        Disease
        Evidence
        References
        model of  cancer
        CEA with wtsx1
        (Busygina et al., 2004)
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        The wing discs of mei-41unspecified mutant third instar larvae exhibit similar levels of apoptosis to controls in response to X-ray induced irradiation. As in controls, very little apoptosis is seen in the absence of irradiation.

        (Brodsky et al., 2004)

        Mutants can be recombination defective. Mutants can show sensitivity to methyl methanesulfonate, nitrogen mustard, UV light, γ rays or X rays. Mutants are not defective in repair of single strand breaks or excision repair, but can be defective in post-replication repair.

        (Gatti, 1979)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        NOT Enhancer of
        Statement
        Reference

        mei-41unspecified is a non-enhancer of visible phenotype of Wee1GMR.PP

        (Price et al., 2002)

        mei-41unspecified is a non-enhancer of visible phenotype of Myt1GMR.PP

        (Price et al., 2002)
        NOT Suppressor of
        Statement
        Reference

        mei-41unspecified is a non-suppressor of visible phenotype of Myt1GMR.PP

        (Price et al., 2002)

        mei-41unspecified is a non-suppressor of visible phenotype of Wee1GMR.PP

        (Price et al., 2002)
        Other
        Phenotype Manifest In
        NOT Enhancer of
        Statement
        Reference

        mei-41unspecified is a non-enhancer of eye phenotype of Wee1GMR.PP

        (Price et al., 2002)

        mei-41unspecified is a non-enhancer of eye phenotype of Myt1GMR.PP

        (Price et al., 2002)
        Suppressor of
        NOT Suppressor of
        Statement
        Reference

        mei-41unspecified is a non-suppressor of egg chorion phenotype of cuffunspecified

        (Chen et al., 2007)

        mei-41unspecified is a non-suppressor of ovary phenotype of CSN5unspecified

        (Doronkin et al., 2003)

        mei-41unspecified is a non-suppressor of eye phenotype of Myt1GMR.PP

        (Price et al., 2002)

        mei-41unspecified is a non-suppressor of eye phenotype of Wee1GMR.PP

        (Price et al., 2002)

        mei-41unspecified is a non-suppressor of karyosome phenotype of vasunspecified

        (Ghabrial and Schupbach, 1999)
        Other
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        mei-41unspecified; wtsx1/+ flies show a higher tumor incidence than controls, with a 2-fold increase at baseline and >10-fold increase after treatment with ionizing radiation.

        (Busygina et al., 2004)

        mei-41unspecified tefuunspecified double mutant third instar larvae usually have melanotic tumours.

        (Song et al., 2004)

        The eggshell defects seen in eggs derived from homozygous spn-D1 or spn-D1/spn-D2 females are suppressed if the females also carry mei-41unspecified.

        (Abdu et al., 2003)

        The ovary phenotype of CSN5unspecified mutants is not suppressed by mei-41unspecified.

        (Doronkin et al., 2003)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Rescued by

        mei-41unspecified is rescued by mei-41+t10.5

        (Hari et al., 1995)
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        mei-41
        (Marek et al., 2008)
        mei-41unspecified
        Name Synonyms
        Secondary FlyBase IDs
          References (14)