Expression of Tl10b.Scer\UAS under the control of Scer\GAL4elav.PU results in significantly decreased number of eve-positive neurons in the ventral nerve cord (VNC) in third instar larvae along with increased number of apoptotic (Dcp-1-positive) cells in the pupal VNC, as compared to driver-only controls.
Expression of Tl10b.Scer\UAS under the control of Scer\GAL4Cg.PA results in the growth of chronic inflammatory hematopoietic tumours in larvae.
Larvae expressing Tl10b.Scer\UAS under the control of Scer\GAL4Hml.Δ show a loss of the sessile hemocyte banding pattern which is seen in wild-type larvae.
Expression of Tl10b.Scer\UAS in all neurons (under the control of Scer\GAL4elav-C155) rescues naturally occuring cell death at embryonic stage 17 (but not at stages 13 and 14), illustrating that Tl can maintain neuronal survival.
When expression is driven by Scer\GAL4He.PZ, hemocyte proliferation and lamellocyte numbers are increased and crystal cells are unaffected. Melanotic masses form.
Expression of Tl10b.Scer\UAS under the control of Scer\GAL4mat.αTub67C.T:Hsim\VP16 during the syncytial blastoderm stage results in ventralised embryos; the denticle belts form circumferential rings and the Filzkorpers are strongly reduced or absent.