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General Information
Symbol
Dmel\Tl10b.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0098792
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-Toll10b, UAS-Tl10b
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulatory sequences drive expression of full length Tl10b sequences.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
model of  collagen disease
is ameliorated by PH4αEFBGD771
ameliorates  hematologic cancer
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of Tl10b.Scer\UAS under the control of Scer\GAL4elav.PU results in significantly decreased number of eve-positive neurons in the ventral nerve cord (VNC) in third instar larvae along with increased number of apoptotic (Dcp-1-positive) cells in the pupal VNC, as compared to driver-only controls.

Third larval instar adipocytes expressing Tl10b.Scer\UAS under the control of Scer\GAL4SPARC-MI00329-GAL4 show a significant increase in both plasma membrane depth and sinuosity compared to control cells.

Expression of Tl10b.Scer\UAS under the control of Scer\GAL4SPARC-MI00329-GAL4 results in elongation of the ventral nerve cord.

Expression of Tl10b.Scer\UAS under the control of Scer\GAL4Cg.PA results in the growth of chronic inflammatory hematopoietic tumours in larvae.

Larvae expressing Tl10b.Scer\UAS under the control of Scer\GAL4Hml.Δ show a loss of the sessile hemocyte banding pattern which is seen in wild-type larvae.

Expression of Tl10b.Scer\UAS in all neurons (under the control of Scer\GAL4elav-C155) rescues naturally occuring cell death at embryonic stage 17 (but not at stages 13 and 14), illustrating that Tl can maintain neuronal survival.

When expression is driven by Scer\GAL4He.PZ, hemocyte proliferation and lamellocyte numbers are increased and crystal cells are unaffected. Melanotic masses form.

Expression of Tl10b.Scer\UAS under the control of Scer\GAL4mat.αTub67C.T:Hsim\VP16 during the syncytial blastoderm stage results in ventralised embryos; the denticle belts form circumferential rings and the Filzkorpers are strongly reduced or absent.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference
Suppressed by
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

The increase in plasma membrane depth seen in third larval instar adipocytes expressing Tl10b.Scer\UAS under the control of Scer\GAL4SPARC-MI00329-GAL4 is suppressed by co-expression of either Rab1JF02609 or DifHM05191.

Simultaneous co-expression of both vkgNIG.16858R and Cg25CGD12784 suppresses the melanotic phenotype caused by expression of Tl10b.Scer\UAS under the control of Scer\GAL4r4.

Co-expression of PH4αEFBGD771 suppresses the melanotic phenotype caused by expression of Tl10b.Scer\UAS under the control of Scer\GAL4r4.

Co-expression of either Gprk2NIG.17998R or Myd88GD9716 suppresses the loss of the sessile hemocyte banding pattern which is seen in larvae expressing Tl10b.Scer\UAS under the control of Scer\GAL4Hml.Δ.

Levels of apoptosis increase in the CNS of spz2 and Tlr3/Df(3R)ro80b mutant embryos, indicating that both spz and Tl are required for neuronal survival.

Xenogenetic Interactions
Statement
Reference

Co-expression of either Zzzz\Pvank1Scer\UAS.T:Zzzz\FLAG or Zzzz\I2vank3Scer\UAS.T:Zzzz\FLAG results in a decrease in both size and number of hematopoietic tumours caused by expression of Tl10b.Scer\UAS under the control of Scer\GAL4Cg.PA.

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Tl10b.Scer\UAS
Tl10b.UAS
Name Synonyms
Secondary FlyBase IDs
    References (16)