Open Close
General Information
Symbol
Dmel\Hsc70-4UAS.cEa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Elefant
FlyBase ID
FBal0098844
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-Hsc70-4.WT, UAS-Hsc70-4
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference
UASt regulatory sequences drive expression of a 2.2kb EcoRI fragment containing the Hsc70-4 coding region.
Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
Expression of Hsc70-4Scer\UAS.cEa under the control of Scer\GAL4Act is able to extend the mean life span under hyperoxic conditions by 24%. Expression of Hsc70-4Scer\UAS.cEa under the control of Scer\GAL4ple.PF rescues the degeneration of dopaminergic neurons that is seen in flies under hyperoxia.
Flies expressing Hsc70-4Scer\UAS.cEa under the control of Scer\GAL4Mhc.PW show normal wing positions.
Expression of Hsc70-4Scer\UAS.cEa under the control of Scer\GAL4337Y has no adverse effects. Embryos expressing Hsc70-4Scer\UAS.cEa under the control of Scer\GAL4how-24B have a wild-type muscle pattern. The majority of newly hatched or 2 day old larvae expressing Hsc70-4Scer\UAS.cEa under the control of Scer\GAL4156Y are able to sense, locate and burrow into a yeast paste food source within 20 minutes in a behavioural assay.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
NOT Enhancer of
Suppressor of
NOT Suppressor of
Phenotype Manifest In
Enhancer of
NOT Enhancer of
Suppressor of
Statement
Reference
NOT Suppressor of
Additional Comments
Genetic Interactions
Statement
Reference
The mechanical stress sensitivity of Tpisgk-1 animals is enhanced if they are also expressing Hsc70-4Scer\UAS.cEa under the control of Scer\GAL4Act5C.Switch.PR (in the presence of Mifepristone).
Xenogenetic Interactions
Statement
Reference
The eye degeneration phenotype as well as formation of inclusions in the ommatidia observed in adult flies expressing Zzzz\CGG100.5'UTR.Scer\UAS.T:Avic\GFP under the control of Scer\GAL4GMR.long (and maintained at 28[o]C) is significantly suppressed by co-expression of Hsc70-4Scer\UAS.cEa
Co-expression of Hsc70-4Scer\UAS.cEa suppresses the ommatidial degeneration and loss of pigmentation induced by Scer\GAL4GMR.PF>Hsap\GJB3F137L.Scer\UAS.T:Hsap\MYC in more than 90% of flies.
Expression of Hsc70-4Scer\UAS.cEa does not suppress the external eye degeneration seen when Zzzz\CAG127Q.Scer\UAS.T:Ivir\HA1 is expressed under the control of Scer\GAL4GMR.PU. Expression of Hsc70-4Scer\UAS.cEa does not suppress the external eye degeneration phenotype seen when Zzzz\CAG127Q.Scer\UAS.T:Ivir\HA1 and DnaJ-1Scer\UAS.cKb are co-expressed under the control of Scer\GAL4GMR.PU.
The eye degeneration phenotype (rough eye with disorganized ommatidial lattice and interommatidial bristles) characteristic for flies expressing Zzzz\CGG90.Scer\UAS.T:Avic\GFP-EGFP under the control of Scer\GAL4GMR.PU is partially rescued by co-expression of Hsc70-4Scer\UAS.cEa.
Coexpression of the Hsc70-4Scer\UAS.cEa transgene results in efficient suppression of the wing posture phenotype of Scer\GAL4Mhc.PW>Hsap\PABPN117ala.Scer\UAS flies.
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Symbol Synonym
Hsc70-4Scer\UAS.cEa
Hsc70-4UAS.cEa
Name Synonyms
Saccharomyces cerevisiae UAS construct a of Elefant
Secondary FlyBase IDs
    References (12)