FB2025_01 , released February 20, 2025
Allele: Dmel\Hsc70-3UAS.cEa
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General Information
Symbol
Dmel\Hsc70-3UAS.cEa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Elefant
FlyBase ID
FBal0098845
Feature type
allele
Associated gene
Dmel\Hsc70-3
Associated Insertion(s)
Carried in Construct
P{UAS-Hsc70-3.WT}
Also Known As
UAS-Hsc70-3.WT, UAS-HSC3, UAS-Bip
Key Links
Transgenic product class
wild_type
(Elefant and Palter, 1999)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Elefant and Palter, 1999)
Mutagen
in vitro construct
(Elefant and Palter, 1999)
Progenitor genotype
Carried in construct
P{UAS-Hsc70-3.WT}
Cytology
Description

UASt regulatory sequences drive expression of a 2.1kb EcoRI fragment containing the Hsc70-3 coding region.

(Elefant and Palter, 1999)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Hsc70-3
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expressing Hsc70-3UAS.cEa under the control of Scer\GAL4elav-C155 does not induce bang sensitivity and has no effect in adult climbing ability or DA neuron number.

      (Mori et al., 2019)

      Expression of Hsc70-3Scer\UAS.cEa under the control of Scer\GAL4Act is able to extend the mean life span under hyperoxic conditions.

      (Gruenewald et al., 2009)

      Expression of Hsc70-3Scer\UAS.cEa under the control of Scer\GAL4337Y has no adverse effects. Expression of Hsc70-3Scer\UAS.cEa under the control of Scer\GAL4how-24B does not result in a mutant phenotype.

      (Elefant and Palter, 1999)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      NOT Enhancer of
      Suppressor of
      NOT Suppressor of
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      Scer\GAL4Act.PU/Hsc70-3UAS.cEa is an enhancer of eye-antennal disc | somatic clone phenotype of scrib1

      (Zheng et al., 2023)
      NOT Enhancer of
      Suppressor of
      NOT Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of Hsc70-3Scer\UAS.cEa suppresses the ommatidial degeneration and loss of pigmentation induced by Scer\GAL4GMR.PF>Hsap\GJB3F137L.Scer\UAS.T:Hsap\MYC in more than 90% of flies.

      (Tang et al., 2015)

      Expression of Hsc70-3Scer\UAS.cEa under the control of Scer\GAL4arm.PS in pcx3 embryos which lack maternal and zygotic pcx function partially rescues the neurogenic phenotype: 67% of embryos are partially rescued and 33% are not rescued.

      (Yamakawa et al., 2012)
      Xenogenetic Interactions
      Statement
      Reference

      Co-expression of Hsc70-3Scer\UAS.cEa fails to suppress the eye phenotypes of adult flies expressing Hsap\ATXN3tr.Q78.Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4GMR.PU.

      Co-expression of Hsc70-3Scer\UAS.cEa fails to suppress the eye phenotypes of flies expressing Hsap\APP2xAPP.SP.Scer\UAS under the control of Scer\GAL4GMR.PU.

      (Fernandez-Funez et al., 2016)

      Expression of Hsc70-3Scer\UAS.cEa does not suppress the external eye degeneration seen when Zzzz\CAG127Q.Scer\UAS.T:Ivir\HA1 is expressed under the control of Scer\GAL4GMR.PU.

      Expression of Hsc70-3Scer\UAS.cEa does not suppress the external eye degeneration phenotype seen when Zzzz\CAG127Q.Scer\UAS.T:Ivir\HA1 and DnaJ-1Scer\UAS.cKb are co-expressed under the control of Scer\GAL4GMR.PU.

      (Kuo et al., 2013)
      Complementation and Rescue Data
      Partially rescues

      Scer\GAL4how-24B/Hsc70-3UAS.cEa partially rescues Hsc70-3D231S.UAS

      (Elefant and Palter, 1999)
      Comments

      Animals expressing Hsc70-3D231S.Scer\UAS under the control of Scer\GAL4how-24B generally die as pupae or larvae (depending on the P{UAS-Hsc70-3.D231S} line used). This lethality is partially rescued by coexpression of Hsc70-3Scer\UAS.cEa.

      (Elefant and Palter, 1999)
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Hsc70-3Scer\UAS.cEa
      Hsc70-3UAS.cEa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Elefant
      (Elefant and Palter, 1999)
      Secondary FlyBase IDs
        References (18)