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General Information
Symbol
Dmel\lncRNA:roX1ex6
Species
D. melanogaster
Name
FlyBase ID
FBal0099841
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
roX1ex6
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
deletion
Comment:
Deleted for bases 25 to 1472 where 1 is first base of GB:U85980.
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Cytology
Nature of the lesion
Statement
Reference
Deletion of nucleotides 25-1472.
1.4kb deletion of sequences within roX1 transcription unit, removing the intron and DNA either side.
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
Normal male development is seen in roX1MB710 animals.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
NOT Enhanced by
Suppressed by
NOT suppressed by
Statement
Reference
Enhancer of
NOT Enhancer of
Statement
Reference
Suppressor of
NOT Suppressor of
Statement
Reference
lncRNA:roX1ex6 is a non-suppressor of lethal | female | heat sensitive phenotype of msl-2Hsp83.PK
Other
Phenotype Manifest In
NOT Enhancer of
Statement
Reference
Df(1)52/lncRNA:roX1ex6 is a non-enhancer of pigment cell | male phenotype of wB1-12
Df(1)52/lncRNA:roX1ex6 is a non-enhancer of pigment cell | female phenotype of w69C
Suppressor of
Statement
Reference
NOT Suppressor of
Statement
Reference
Df(1)52/lncRNA:roX1ex6 is a non-suppressor of pigment cell | male phenotype of wB1-12
Df(1)52/lncRNA:roX1ex6 is a non-suppressor of pigment cell | female phenotype of w69C
Additional Comments
Genetic Interactions
Statement
Reference
One paternally-derived copy of roX1ex6 reduces the viability of scsisB-1 sisA1/+ females.
The puffing of the male X polytene chromosome that is seen in E(bx)Nurf301-3 mutants is regionally inhibited if they are also mutant for roX1 (carrying roX1ex6); in this case, puffing of a large portion of the distal X, including the region around the roX1 locus, is strongly reduced, while the rest of the chromosome still displays a puffed morphology. Chromosomal decondensation surrounding autosomal insertions of P{GMroX2} is seen in polytene chromosomes if E(bx)Nurf301-3 is introduced into a roX1- roX2- background (roX1ex6 Df(1)52 P{w+4Δ4.3}) carrying P{GMroX2} insertions.
Only 5% of roX1ex6 Df(1)52 hemizygous males with P{w+4Δ4.3} survive to adulthood, but these animals are abundant and healthy at late third instar. Survival to adulthood is partially rescued (to 11.9%) by msl-1Hsp83.PC; msl-2Hsp83.PK.
The addition of msl-1Hsp83.PC and msl-2Hsp83.PK to roX1ex6 males reduces their viability. roX1ex6, Df(1)52 males have a very low viability, only up to 6.6% of males survive. This loss of viability is partially rescued by adding msl-1Hsp83.PC and msl-2Hsp83.PK, with up to 45% of males surviving.
The majority of roX1ex6; Df(1)52 double homozygous males carrying P{w+4Δ4.3} do not survive to adulthood. This male lethality is almost completely rescued by roX2ΔDHS.Hsp83.
roX1ex6 Df(1)52/Y males carrying P{w+4Δ4.3} generally do not survive to adulthood. This lethality is substantially rescued by an autosomal copy of roX1Hsp83.PM, roX1Δ1.Hsp83, roX1Δ2.Hsp83, roX1Δ3.Hsp83, roX1Δ4.Hsp83, roX1Δ5.Hsp83, roX1Δ6.Hsp83, roX1Δ7.Hsp83, roX1Δ8.Hsp83, roX1Δ9.Hsp83, roX1Δ30.Hsp83, roX1L.Hsp83 or roX1SL.Hsp83. roX1ex6 Df(1)52/Y males carrying P{w+4Δ4.3} generally do not survive to adulthood. This lethality is weakly rescued by an autosomal copy of roX1Δ11.Hsp83. roX1ex6 Df(1)52/Y males carrying P{w+4Δ4.3} generally do not survive to adulthood. This lethality is not substantially rescued by an autosomal copy of roX1a.Hsp83, roX1Hsp83.5', roX1Hsp83.3' or roX1Δ10.Hsp83. roX1ex6 Df(1)52/Y males carrying P{w+4Δ4.3} generally do not survive to adulthood. This lethality is partly rescued by an autosomal copy of roX1ΔO.Hsp83, roX1ΔIR.Hsp83, roX15'S.Hsp83 or roX13'S.Hsp83.
Males carrying roX1ex6,Df(1)52/Y ; P{w+4Δ4.3} exhibit only 5% survival. Df(1)52 deletes roX2 amongst other genes, P{w+4Δ4.3} is a cosmid that contains most of the genes deleted by Df(1)52, but not roX2. Females homozygous for roX1ex6,Df(1)52 and also carrying P{w+4Δ4.3} are viable. The addition of roX2Hsp83.PH to males carrying roX1ex6,Df(1)52/Y ; P{w+4Δ4.3} suppresses the lethality seen in those animals.
Eye colour: the expression of w69C in females carrying w69C in a w- background is unchanged if they are also carrying roX1ex6 Df(1)52 P{w+4Δ4.3}. Eye colour: males carrying w69C in a w- background that are also carrying roX1ex6 Df(1)52 P{w+4Δ4.3} show almost complete derepression of w69C expression in the ventral part of the eye. Eye colour: the expression of wB1-12 in males carrying wB1-12 in a w- background is unchanged if they are also carrying roX1ex6 Df(1)52 P{w+4Δ4.3} (these are escaper males). About 99% of roX1ex6 Df(1)52 P{w+4Δ4.3} males die.
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Partially rescued by
Comments
P{GMroX1}75C (which carries roX1t4.9) partially rescues the lethality of roX1ex6/Df(1)52 males.
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
References (29)