FB2025_01 , released February 20, 2025
Allele: Dmel\ppl06913
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General Information
Symbol
Dmel\ppl06913
Species
D. melanogaster
Name
FlyBase ID
FBal0099845
Feature type
allele
Associated gene
Dmel\ppl
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

loss of function allele

Mutagen
    Nature of the Allele
    Allele class

    loss of function allele

    (Zinke et al., 1999)
    Mutagen
    Progenitor genotype
    Caused by aberration
    Df(2L)ppl06913
    Cytology
    Description

    Deletion removing portion of Eip78C transcription unit, extending proximally from site of P{PZ}Eip78C06913, and deleting AcCoAS and ppl sequences.

    (Zinke et al., 1999)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        In contrast to wild-type controls, mutant larvae tend to wander away from a food source.

        (Walker et al., 2013)

        Food remains in the pharynx of mutant animals and does not move from the pharynx into the esophagus. This feeding defect starts late in the first larval instar. The mutant phenotype has a progressive onset, and the larvae vary in size, probably reflecting the variation in time when food ceases to move to the midgut. Larvae do not show a typical starvation behavioral response, but wander away from the food. Physiological response to starvation is also abnormal.

        (Zinke et al., 1999)

        Mutants show a show a defect in food intake and die as small larvae. The larvae feed normally upon hatching, however, during the late first instar stage they begin having difficulty in passing the food from the pharynx into the oesophagus. Soon afterwards, the larvae leave the food source and start moving about.

        (Zinke et al., 1999)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        Comments
        Comments

        Null allele.

        (Zinke et al., 1999)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (4)
        Reported As
        Symbol Synonym
        l(3)06913
        (Spradling et al., 1999)
        l(3)78Cb06913
        ppl-06913
        (Zinke et al., 1999)
        ppl06913
        (Walker et al., 2013)
        Name Synonyms
        Secondary FlyBase IDs
          References (5)