FB2022_02, released March 29, 2022

Allele: Dmel\l(3)64AbS137212

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General Information
Symbol
Dmel\l(3)64AbS137212
Species
D. melanogaster
Name
FlyBase ID
FBal0099884
Feature type
allele
Associated gene
l(3)64Ab
Associated Insertion(s)
P{lacW}l(3)64AbS137212
Carried in Construct
Key Links
Genomic Maps
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
Delta2-3 transposase
(Deak et al., 1997)
P-element activity
(Szeged Stock Center, 1998-)
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
transposable_element_insertion_site
3L:4,104,188..4,104,188 [+]
(Sem et al., 2002, Szeged Stock Center, 1998-, Deak et al., 1997)
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
       
      Progenitor genotype
      Cytology
      Nature of the lesion
      Statement
      Reference

      Insertion maps 72bp upstream of the predicted initiator methionine codon of Fit1.

      (Sem et al., 2002)
      Insertion components
      P{lacW}l(3)64AbS137212
      Product class / Tool use(s)
      Encoded product / tool
      lacZ
      Tagged with
      Tag:NLS(P)
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      The P{lacW}l(3)64AbS137212 insertion maps 72bp upstream of the predicted initiator methionine codon of Fit1. Overexpression of an Ack transgene (the gene immediately downstream of Fit1) does not rescue the lethality of the insertion, suggesting that it is more likely to be affecting the function of Fit1 rather than Ack.

      (Sem et al., 2002)
      Comments
      Comments

      Excision of the insertion can revert the lethal phenotype.

      (Sem et al., 2002)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      1372/12
      (Deak et al., 1997)
      l(3)64AbS137212
      l(3)S137212S137212
      Name Synonyms
      Secondary FlyBase IDs
        References (3)