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General Information
Symbol
Dmel\krzS095214
Species
D. melanogaster
Name
FlyBase ID
FBal0099971
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
krz2
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

P{lacW} insertion approximately 60kb upstream of the krz locus.

Insertion components
P{lacW}krzS095214
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Homozygotes die throughout development. Most animals fail to hatch and none of the surviving larvae live to puparium formation. The formation of melanotic tumours and fat body disaggregation is identical to that seen in krzS047819 animals. Tumours form throughout the body cavity but most frequently collect in the posterior of the larva. Tumours are frequently found floating free in the haemocoel.

Lethality acts in the second larval instar.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference

krz[+]/krzS095214 is an enhancer of visible | recessive phenotype of dxS1M

Phenotype Manifest In
Enhancer of
Statement
Reference

krz[+]/krzS095214 is an enhancer of wing margin phenotype of dxS1M

krz[+]/krzS095214 is an enhancer of wing vein phenotype of dxS1M

Additional Comments
Genetic Interactions
Statement
Reference

The notching and vein thickening phenotypes seen in dxS1M hemizygous males are enhanced by krzS095214/+. Survival of NAx-9/NAx-E2 dxENU/+ flies to adulthood is significantly decreased by krzS095214/+.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Rescued by
Comments

Lethality is rescued by krz+t12.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer

It is possible that an undetected second site mutation at the krz locus and not the P{lacW}krzS095214 insertion (which maps approximately 60kb upstream of the krz locus) disrupts the expression of krz. However, no polymorphisms have been detected by restriction analysis within a 12kb SphI fragment that includes both mod and krz, and no sequence changes in approximately 4.5kb of the krz gene and promoter region have been detected in krzS095214 mutants.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (5)
Reported As
Symbol Synonym
krzS095214
l(3)S095214S095214
Name Synonyms
Secondary FlyBase IDs
    References (4)