FB2025_01 , released February 20, 2025
Allele: Dmel\trcS066917a
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General Information
Symbol
Dmel\trcS066917a
Species
D. melanogaster
Name
FlyBase ID
FBal0100048
Feature type
allele
Associated gene
Dmel\trc
Associated Insertion(s)
P{lacW}trcS066917a
Carried in Construct
Also Known As
trc7, 0669/17, trcP
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
Delta2-3 transposase
(Deak et al., 1997)
P-element activity
(Szeged Stock Center, 1998-)
Progenitor genotype
Associated Insertion(s)
P{lacW}trcS066917a
Cytology
Description

P{lacW} insertion in the first intron.

(Geng et al., 2000)
Allele components
Component
Use(s)
Inserted element
P{lacW}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mutant cells in trcS066917a large clones in the pupal wing often have an irregular shape, and their average cross-sectional area is ~1.6-fold larger than control neighboring cells. Hair morphogenesis is delayed in the trcS066917a mutant cells.

      trcS066917a mutants show a multiple wing hair phenotype.

      Expression of trcS292A.Scer\UAS under the control of Scer\GAL4ap-md544 in a trcS066917a/+ background enhances the multiple wing hair phenotype seen when trcS066917a is expressed in a wild-type background.

      (He et al., 2005)

      Homozygous second instar larvae have many split denticles per segment.

      (He et al., 2005)

      Hemizygous flies have branched arista laterals.

      (He and Adler, 2002)

      Homozygous clones have a multiple wing hair phenotype (5.74 hairs/cell).

      (Cong et al., 2001)

      Mutant cells in homozygous clones in the wing show a strong multiple hair cell phenotype. The number of hairs per cell varies between different clones from an average of 3.5 hairs per cell to more than 7 hairs per cell. Mutant cells in pupal wings have on average a weaker phenotype than clones in adult wings. A substantial number of cells in the clone in pupal wings do not have a multiple wing hair phenotype, in contrast to adult wings. When a wing cell produces a single hair in pupal clones, the hair appears to be the same length as neighbouring wild-type hairs. Only mutant cells show the multiple hair phenotype in pupal wings containing homozygous clones.

      (Geng et al., 2000)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      trcS066917a has lethal phenotype, suppressible by Hsap\STK38UAS.cHa/Scer\GAL4Act5C.PI

      (He et al., 2005)
      Other
      Statement
      Reference

      fry1/fry[+], matse03077, trc[+]/trcS066917a has visible | dominant phenotype

      (He et al., 2005)
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      trcS066917a has wing hair | increased number phenotype, suppressible by Hsap\STK38UAS.cHa/Scer\GAL4Act5C.PI

      (He et al., 2005)
      Other
      Statement
      Reference

      fry1/fry[+], matse03077, trc[+]/trcS066917a has wing hair | increased number phenotype

      (He et al., 2005)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      fry1 trcS066917a matse03077 triple heterozygotes have a weak multiple wing hair phenotype in 40% of wings.

      The split denticle phenotype of matse03077 trcS066917a double mutant second instar larvae is no more severe than the split denticle phenotype of each single mutant.

      (He et al., 2005)

      trcS066917a fry1 double mutant clones do not have a stronger multiple wing hair phenotype (5.37 hairs/cell) than either single mutant.

      (Cong et al., 2001)
      Xenogenetic Interactions
      Statement
      Reference

      Expression of Hsap\NDRG1Scer\UAS.cHa under the control of Scer\GAL4Act5C.PI rescues both the lethality and the multiple wing hair phenotype of trcS066917a mutants.

      (He et al., 2005)
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      Separable from: prosS066917b.

      (Szeged Stock Center, 1998-)
      Comments
      Comments

      Excision of the P{lacW} element can result in reversion of the phenotype.

      (Geng et al., 2000)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (6)
      Reported As
      Symbol Synonym
      0669/17
      (Geng et al., 2000, Deak et al., 1997)
      l(3)S066917S066917
      l(3)S066917S066917a
      trc7
      (Emoto et al., 2004, Lee and Adler, 2004, He and Adler, 2002, Cong et al., 2001, Geng et al., 2000)
      trcP
      (He et al., 2005, He et al., 2005)
      trcS066917a
      Name Synonyms
      Secondary FlyBase IDs
        References (9)