Allele Dmel\dome^G0441

General Information
Symbol	Dmel\dome^G0441	Species	D. melanogaster
Name		FlyBase ID	FBal0100259
Feature type	allele	Associated gene	Dmel\dome
Also Known As	l(1)G0441, dome⁴⁴¹

Map ( GBrowse )	Untitled Document
Allele class	loss of function allele
Mutagen	P-element activity
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	loss of function allele (Castelli-Gair Hombria, 2001.9.19)
Mutagen	P-element activity (Schaefer et al., 1999.8.12)
Mutations Mapped to the Genome

Type Location Additional Notes References transposable element insertion site X:19,576,958..19,577,333 (Schaefer et al., 1999.8.12, Brown et al., 2001, Castelli-Gair Hombria, 2001.9.19, Chen et al., 2002, Ghiglione et al., 2002, Peter et al., 2002)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AJ427007

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference P{lacW} insertion in the 5' untranslated region. (Chen et al., 2002) P-element insertion in the 5' UTR. (Ghiglione et al., 2002) P{lacW} insertion in the 5' UTR, at nucleotide position 376 of dome EST LD32858. (Brown et al., 2001) Insertion of P{lacW} into 5' UTR of dome, at position of 376bp with respect to the start of LD32858. (Castelli-Gair Hombria, 2001.9.19)
Caused by insertion	P{lacW}dome^G0441 (Schaefer et al., 1999.8.12, Brown et al., 2001, Castelli-Gair Hombria, 2001.9.19, Chen et al., 2002, Ghiglione et al., 2002, Peter et al., 2002)
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| embryonic stage (Peter et al., 2002) lethal \| larval stage (Peter et al., 2002) lethal \| recessive (Castelli-Gair Hombria, 2001.9.19, Schaefer et al., 1999.8.12)
Phenotype Manifest In
	border follicle cell \| somatic clone (Ghiglione et al., 2002) embryonic/larval posterior spiracle (Brown et al., 2001, Chen et al., 2002) embryonic/larval spiracle (Castelli-Gair Hombria, 2001.9.19) embryonic abdominal segment 4 \| non-rescuable maternal effect \| posterior (Chen et al., 2002) embryonic abdominal segment 5 \| non-rescuable maternal effect (Chen et al., 2002) embryonic head \| rescuable maternal effect (Chen et al., 2002) embryonic thoracic segment \| rescuable maternal effect (Chen et al., 2002) presumptive embryonic/larval tracheal system (Chen et al., 2002)
Detailed Description
	Statement Reference Homozygous embryos have a posterior spiracle defect. Embryos derived from females containing homozygous germ-line clones die with segmentation defects. Both paternally rescued and non-rescued embryos show a consistent deletion of the 5th abdominal segment and the posterior midventral part of the 4th abdominal segment. Additional defects in the thoracic segments and head and tail regions are seen in paternally non-rescued embryos. Paternally rescued embryos derived from females containing homozygous germ-line clones form a defective tracheal system with several disruptions in the main trunk and many branches. (Chen et al., 2002) Mosaic egg chambers in which the border cells are dome^G0441 show a lack of or defective border cell migration. In some mosaic egg chambers the border cell clusters are not formed or contain less cells than normal. In mosaic border cell clusters, the wild-type cells usually migrate normally or ahead of the dome^G0441 cells. (Ghiglione et al., 2002) Lethality occurs during the embryonic stage and the first larval instar. (Peter et al., 2002) The shape of the posterior spiracles is affected in mutants. (Brown et al., 2001)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement Reference dome^G0441/dome[+] is a suppressor \| partially of visible phenotype of Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, os^Scer\UAS.cCa (Chen et al., 2002)
Phenotype Manifest In
Suppressed by
Statement Reference dome^G0441 has embryonic/larval posterior spiracle phenotype, suppressible by hop^Tum (Chen et al., 2002)
Suppressor of
Statement Reference dome^G0441/dome[+] is a suppressor \| partially of eye phenotype of Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, os^Scer\UAS.cCa (Chen et al., 2002) dome^G0441/dome[+] is a suppressor \| partially of ommatidium \| supernumerary phenotype of Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, os^Scer\UAS.cCa (Chen et al., 2002)
Additional Comments
Genetic Interactions
Statement Reference The extra number of ommatidia caused by expression of os^Scer\UAS.cCa under the control of Scer\GAL4^GMR.PF is partially suppressed by dome^G0441/+; the flies have an average of 813 +/- 10 ommatidia. (Chen et al., 2002)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescued by	dome^G0441 is rescued by dome^5.1 (Castelli-Gair Hombria, 2001.9.19) dome^G0441 is rescued by dome^hs.PC (Chen et al., 2002)
Comments
Stocks ( 1 )
Bloomington	12030 w^67c23 P{lacW}dome^G0441/FM7c
Notes on Origin
Discoverer

Comments
	Mobilisation of the P-element reverts both the lethality and posterior spiracle phenotype. (Brown et al., 2001) P{lacW} not verified as causing the lethality. (Schaefer et al., 1999.8.12)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 5 )
Reported As
Symbol Synonym	dome⁴⁴¹ (Brown et al., 2001, Castelli-Gair Hombria, 2001.9.19) dome^G0441 l(1)G0441 (Peter et al., 2002, Chen et al., 2002) l(1)G0441^G0441 (Schaefer et al., 1999.8.12, ) mom¹ (Chen et al., 2002)
Name Synonym
Secondary FlyBase IDs

References ( 7 )
Research paper	Chen et al., 2002, Genes Dev. 16(3): 388--398 mom identifies a receptor for the Drosophila JAK/STAT signal transduction pathway and encodes a protein distantly related to the mammalian cytokine receptor family. [FBrf0144881] Ghiglione et al., 2002, Development 129(23): 5437--5447 The Drosophila cytokine receptor Domeless controls border cell migration and epithelial polarization during oogenesis. [FBrf0151938] Brown et al., 2001, Curr. Biol. 11(21): 1700--1705 Identification of the first invertebrate interleukin JAK/STAT receptor, the Drosophila gene domeless. [FBrf0141438]
Supplementary material	Peter et al., 2002, EMBO Rpts 3(1): Supplementary material. PX-lines.txt. [FBrf0173176]
Personal communication to FlyBase	Popodi et al., 2010-, Small X duplications for the stock center collection. Small X duplications for the stock center collection. [FBrf0210621] Castelli-Gair Hombria, 2001.9.19, domeless. domeless. [FBrf0138617] Schaefer et al., 1999.8.12, Goettingen lethals - set 3. Goettingen lethals - set 3. [FBrf0109189]

Allele Dmel\domeG0441

Allele Dmel\dome^G0441