FB2025_01 , released February 20, 2025
Allele: Dmel\domeG0441
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General Information
Symbol
Dmel\domeG0441
Species
D. melanogaster
Name
FlyBase ID
FBal0100259
Feature type
allele
Associated gene
Dmel\dome
Associated Insertion(s)
P{lacW}domeG0441
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Castelli-Gair Hombria, 2001.9.19)
Mutagen
P-element activity
(Schäfer et al., 1999.8.12)
Progenitor genotype
Associated Insertion(s)
P{lacW}domeG0441
Cytology
Description

P{lacW} insertion in the 5' untranslated region.

(Chen et al., 2002)

P-element insertion in the 5' UTR.

(Ghiglione et al., 2002)

P{lacW} insertion in the 5' UTR, at nucleotide position 376 of dome EST LD32858.

(Brown et al., 2001)

Insertion of P{lacW} into 5' UTR of dome, at position of 376bp with respect to the start of LD32858.

(Castelli-Gair Hombria, 2001.9.19)
Allele components
Component
Use(s)
Inserted element
P{lacW}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
AJ427007
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      domeG0441 heterozygotes do not show significant changes in intestinal stem cell proliferation (phospho-H3 staining) in the adult midgut, as compared to controls.

      (Gultekin and Steller, 2019)

      Homozygous embryos have a posterior spiracle defect. Embryos derived from females containing homozygous germ-line clones die with segmentation defects. Both paternally rescued and non-rescued embryos show a consistent deletion of the 5th abdominal segment and the posterior midventral part of the 4th abdominal segment. Additional defects in the thoracic segments and head and tail regions are seen in paternally non-rescued embryos. Paternally rescued embryos derived from females containing homozygous germ-line clones form a defective tracheal system with several disruptions in the main trunk and many branches.

      (Chen et al., 2002)

      Mosaic egg chambers in which the border cells are domeG0441 show a lack of or defective border cell migration. In some mosaic egg chambers the border cell clusters are not formed or contain less cells than normal. In mosaic border cell clusters, the wild-type cells usually migrate normally or ahead of the domeG0441 cells.

      (Ghiglione et al., 2002)

      Lethality occurs during the embryonic stage and the first larval instar.

      (Peter et al., 2002)

      The shape of the posterior spiracles is affected in mutants.

      (Brown et al., 2001)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      domeG0441/dome[+] is a suppressor of increased occurrence of cell division | adult stage phenotype of Rnf14617

      (Gultekin and Steller, 2019)

      domeG0441/dome[+] is a suppressor of visible phenotype of Scer\GAL4GMR.PF, upd1UAS.cCa

      (Chen et al., 2002)
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      domeG0441 has embryonic/larval posterior spiracle phenotype, suppressible by hopTum

      (Chen et al., 2002)
      Suppressor of
      Statement
      Reference

      domeG0441/dome[+] is a suppressor of adult midgut epithelium phenotype of Rnf14617

      (Gultekin and Steller, 2019)

      domeG0441/dome[+] is a suppressor of intestinal stem cell | adult stage phenotype of Rnf14617

      (Gultekin and Steller, 2019)

      domeG0441/dome[+] is a suppressor of eye phenotype of Scer\GAL4GMR.PF, upd1UAS.cCa

      (Chen et al., 2002)

      domeG0441/dome[+] is a suppressor of ommatidium | increased number phenotype of Scer\GAL4GMR.PF, upd1UAS.cCa

      (Chen et al., 2002)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The extra number of ommatidia caused by expression of upd1Scer\UAS.cCa under the control of Scer\GAL4GMR.PF is partially suppressed by domeG0441/+; the flies have an average of 813 +/- 10 ommatidia.

      (Chen et al., 2002)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      domeG0441 is rescued by domehs.PC

      (Chen et al., 2002)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      P{lacW} not verified as causing the lethality.

      (Schäfer et al., 1999.8.12)

      Mobilisation of the P-element reverts both the lethality and posterior spiracle phenotype.

      (Brown et al., 2001)
      External Crossreferences and Linkouts ( 1 )
      Crossreferences
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      Synonyms and Secondary IDs (6)
      Reported As
      Symbol Synonym
      dome441
      (Brown et al., 2001, Castelli-Gair Hombria, 2001.9.19)
      domeG0441
      (Wang et al., 2022)
      l(1)G0441
      (Chen et al., 2002, Peter et al., 2002)
      l(1)G0441G0441
      (Schäfer et al., 1999.8.12)
      mom1
      (Chen et al., 2002)
      ΔDome
      (Gultekin and Steller, 2019)
      Name Synonyms
      Secondary FlyBase IDs
        References (9)