FlyBase Allele Report: Dmel\Moe[G0415]

FB2025_01 , released February 20, 2025

FB2025_01 , released February 20, 2025

Allele: Dmel\Moe^G0415

General Information

Symbol

Dmel\Moe^G0415

Species

D. melanogaster

Name

FlyBase ID

FBal0100274

Feature type

allele

Associated gene

Associated Insertion(s)

P{lacW}Moe^G0415

Carried in Construct

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Jankovics et al., 2002, Schäfer et al., 1999.8.12)

Progenitor genotype

Associated Insertion(s)

P{lacW}Moe^G0415

Cytology

Description

Allele components

Component

Use(s)

Inserted element

Encoded product / tool

reporter enzyme

Tagged with

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal developmental rate | female (with Moe^NES)

(Bajusz et al., 2021)

abnormal neuroanatomy | third instar larval stage

(Ruan et al., 2013)

decreased size | maternal effect | oogenesis (with Moe^NES)

(Bajusz et al., 2021)

decreased size | maternal effect | spermatogenesis (with Moe^NES)

(Bajusz et al., 2021)

grandchildless | female (with Moe^NES)

(Bajusz et al., 2021)

lethal | recessive

(Schäfer et al., 1999.8.12)

majority die during embryonic stage | maternal effect (with Moe^NES)

(Bajusz et al., 2021)

partially lethal - majority die

(Peter et al., 2002)

short lived | female | heat sensitive (with Moe^NES)

(Bajusz et al., 2021)

some die during larval stage | maternal effect (with Moe^NES)

(Bajusz et al., 2021)

some die during P-stage | maternal effect (with Moe^NES)

(Bajusz et al., 2021)

sterile | maternal effect (with Moe^NES)

(Bajusz et al., 2021)

viable | female (with Moe^NES)

(Bajusz et al., 2021)

visible | adult stage | maternal effect (with Moe^NES)

(Bajusz et al., 2021)

Phenotype Manifest In

abdominal tergite | adult stage | maternal effect (with Moe^NES)

(Bajusz et al., 2021)

crossvein | maternal effect (with Moe^NES)

(Bajusz et al., 2021)

eye | maternal effect (with Moe^NES)

(Bajusz et al., 2021)

germline cell | embryonic stage (with Moe^EP1652)

(Jankovics et al., 2002)

germline cell | embryonic stage (with Moe^GT193)

(Jankovics et al., 2002)

lamina plexus | third instar larval stage

(Ruan et al., 2013)

male genitalia | absent | maternal effect (with Moe^NES)

(Bajusz et al., 2021)

medulla | third instar larval stage

(Ruan et al., 2013)

oocyte & cytoskeleton (with Moe^EP1652)

(Jankovics et al., 2002)

ovary | maternal effect (with Moe^NES)

(Bajusz et al., 2021)

testis | maternal effect (with Moe^NES)

(Bajusz et al., 2021)

wing margin | maternal effect (with Moe^NES)

(Bajusz et al., 2021)

Detailed Description

Statement

Reference

Hemizygous third instar larvae have gaps in the laminar plexus. Abnormally thick axons bundles that project into the medulla and have abnormal wandering projections are seen. The growth cones in the medulla are enlarged and often overlap with each other.

(Ruan et al., 2013)

60% of embryos from Moe^EP1652/Moe^G0415 mothers lack germ cells. In Moe^EP1652/Moe^G0415 oocytes, the actin cytoskeleton is detached from the cortex. Only 1% of embryos from Moe^G0415/Moe^GT193, mothers lack germ cells.

(Jankovics et al., 2002)

External Data

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescued by

Moe^G0415 is partially rescued by Scer\GAL4^elav.PU/Moe^{K.UAS.Tag:MYC}

(Ruan et al., 2013)

Comments

Expression of Moe^{K.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^elav.PU rescues the R2-R5 axon targeting defects seen in Moe^G0415 hemizygotes in 55% of cases.

(Ruan et al., 2013)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Comments

P{lacW} not verified as causing the lethality.

(Schäfer et al., 1999.8.12)

External Crossreferences and Linkouts ( 1 )

Crossreferences

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

AJ426798

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

Dmoe^G0415

(Jankovics et al., 2002)

Moe^G0415

(Bajusz et al., 2021)

Moe^G041

(Jankovics et al., 2002)

l(1)G0415

(Peter et al., 2002)

l(1)G0415^G0415

(Schäfer et al., 1999.8.12)

moe^G0415

(Ruan et al., 2013)

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections