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General Information
Symbol
Dmel\ctpG0371
Species
D. melanogaster
Name
FlyBase ID
FBal0100301
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Insertion components
P{lacW}ctpG0371
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 1 )
 
Hsap\ARQ52.Scer\UAS disease model requires Hsap\AR ligand testosterone. Larvae raised in the presence of dihydroxytestosterone.
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
Head eversion occurs at 15 hours after puparium formation in ctpG0371 mutant pupae. 12 hours after head eversion, a defect in salivary gland death is evident. All pupae fail to complete salivary gland degradation, compared to control animals which completely lack salivary glands at this stage. 39% of mutant pupae have intact glands, and 61% display partially fragmented salivary glands. Autophagy is defective in ctpG0371 mutant salivary glands, and the number of autophagosomes present in salivary gland cells is reduced compared to controls. ctpG0371 mutant salivary gland cells contain protein inclusions. ctpG0371 mutant third instar larvae display motility defects. ctpG0371 mutants possess decreased neuromuscular junction bouton numbers compared to controls, and protein inclusions are present in larval muscles.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Phenotype Manifest In
Enhanced by
Statement
Reference
Suppressed by
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference
Expression of Atg1GS10797 in the salivary glands under the control of Scer\GAL4fkh.PH in ctpG0371 mutant animals eliminates the accumulation of protein inclusions in salivary gland cells.
Xenogenetic Interactions
Statement
Reference
Expression of BacA\p35Scer\UAS.cHa under the control of Scer\GAL4da.G32 in ctpG0371 mutant animals results in almost complete inhibition of salivary gland degradation, and 96% of animals display intact salivary glands. Larval motility defects observed in animals expressing Hsap\ARQ52.Scer\UAS in motor neurons under the control of Scer\GAL4D42 and fed on food supplemented with DHT, is enhanced in a ctpG0371 mutant background.
Complementation and Rescue Data
Partially rescued by
Comments
Expression of ctpScer\UAS.cBa under the control of Scer\GAL4fkh.PH in ctpG0371 mutant animals rescues the defects in salivary gland degradation. Most animals have no salivary glands, with a small number showing fragmented salivary glands. Expression of ctpScer\UAS.cBa throughout development under the control of Scer\GAL4da.G32 rescues the viability of 63% of ctpG0371 adult males.
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
Comments
Comments
P{lacW} not verified as causing the lethality.
External Crossreferences and Linkouts ( 1 )
Crossreferences
GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (5)