FB2025_01 , released February 20, 2025
Allele: Dmel\SmrG0361
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General Information
Symbol
Dmel\SmrG0361
Species
D. melanogaster
Name
FlyBase ID
FBal0100305
Feature type
allele
Associated gene
Dmel\Smr
Associated Insertion(s)
P{lacW}SmrG0361
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Schäfer et al., 1999.8.12)
Progenitor genotype
Associated Insertion(s)
P{lacW}SmrG0361
Cytology
Description
Allele components
Component
Use(s)
Inserted element
P{lacW}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
AJ426884
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous females and hemizygous males are lethal.

      (Heck et al., 2012)

      Lethality occurs during the first and second larval instars.

      (Peter et al., 2002)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      SmrG0361 is a suppressor of visible phenotype of HUAS.cMa, Scer\GAL4GMR.PF

      (Müller et al., 2005)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      SmrG0361 is a suppressor of eye phenotype of HUAS.cMa, Scer\GAL4GMR.PF

      (Müller et al., 2005)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      SmrG0124

      (Heck et al., 2012)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      Dp(1;Y)BSC5 (a duplication containing Smr) cannot rescue the lethality of "G0361" homozygotes, suggesting that this line may contain secondary lethal mutations in addition to the SmrG0361 allele.

      (Heck et al., 2012)
      Comments
      Comments

      P{lacW} not verified as causing the lethality.

      (Schäfer et al., 1999.8.12)
      External Crossreferences and Linkouts ( 1 )
      Crossreferences
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      SmrG0361
      (Christensen et al., 2008.9.29, Christensen et al., 2008.9.29)
      l(1)G0361
      (Peter et al., 2002)
      l(1)G0361G0361
      (Schäfer et al., 1999.8.12)
      smrG0361
      (Müller et al., 2005)
      Name Synonyms
      Secondary FlyBase IDs
        References (6)