FlyBase Allele Report: Dmel\Dlic[G0190]

General Information

Symbol

Dmel\Dlic^G0190

Species

D. melanogaster

Name

FlyBase ID

FBal0100338

Feature type

allele

Associated gene

Dmel\Dlic

Associated Insertion(s)

P{lacW}Dlic^G0190

Carried in Construct

Also Known As

dlic2^G0190

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Schäfer et al., 1999.8.12)

Progenitor genotype

Associated Insertion(s)

P{lacW}Dlic^G0190

Cytology

Description

Insertion in the splice donor site in the seventh intron.

(Mische et al., 2008)

Allele components

Component

Use(s)

Inserted element

P{lacW}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

X:11,162,456..11,162,807 [+]

(Mische et al., 2008, Peter et al., 2002, Schäfer et al., 1999.8.12)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

AJ426856

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates tauopathy

modeled by Hsap\MAPT^GMR.Ex.PJ

(Ambegaokar and Jackson, 2011)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Schäfer et al., 1999.8.12)

lethal - all die before end of larval stage

(Peter et al., 2002)

lethal - all die before end of larval stage | recessive

(Mische et al., 2008)

some die during larval stage

(Peter et al., 2002)

some die during larval stage | recessive

(Mische et al., 2008)

Phenotype Manifest In

Detailed Description

Statement

Reference

Lethality occurs during the first larval instar.

(Peter et al., 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Dlic^G0190/Dlic2[+] is an enhancer of visible phenotype of Scer\GAL4^GMR.PF, bchs^EP2299

(Simonsen et al., 2007)

Suppressor of

Statement

Reference

Dlic^G0190/Dlic[+] is a suppressor of visible phenotype of Hsap\MAPT^UAS.S11A, Scer\GAL4^GMR.PS

(Ambegaokar and Jackson, 2011)

Dlic^G0190/Dlic[+] is a suppressor of visible phenotype of Hsap\MAPT^GMR.Ex.PJ

(Ambegaokar and Jackson, 2011)

NOT Suppressor of

Statement

Reference

Dlic^G0190/Dlic[+] is a non-suppressor of visible phenotype of Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS

(Ambegaokar and Jackson, 2011)

Phenotype Manifest In

Enhancer of

Statement

Reference

Dlic^G0190/Dlic2[+] is an enhancer of eye phenotype of Scer\GAL4^GMR.PF, bchs^EP2299

(Simonsen et al., 2007)

Suppressor of

Statement

Reference

Dlic^G0190/Dlic[+] is a suppressor of eye phenotype of Hsap\MAPT^UAS.S11A, Scer\GAL4^GMR.PS

(Ambegaokar and Jackson, 2011)

Dlic^G0190/Dlic[+] is a suppressor of eye phenotype of Hsap\MAPT^GMR.Ex.PJ

(Ambegaokar and Jackson, 2011)

NOT Suppressor of

Statement

Reference

Dlic^G0190/Dlic[+] is a non-suppressor of eye phenotype of Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS

(Ambegaokar and Jackson, 2011)

Additional Comments

Genetic Interactions

Statement

Reference

One copy of Dlic^G0190 does not suppress the apoptosis seen in flies overexpressing hid.

(Ambegaokar and Jackson, 2011)

Xenogenetic Interactions

Statement

Reference

One copy of Dlic^G0190 suppresses the rough eye phenotype seen in flies expressing Hsap\MAPT^GMR.Ex.PJ.

One copy of Dlic^G0190 suppresses the rough eye phenotype seen in flies expressing Hsap\MAPT^{Scer\UAS.S11A} under the control of Scer\GAL4^GMR.PS.

One copy of Dlic^G0190 does not suppress the rough eye phenotype seen in flies expressing Zzzz\CAG^{Q108.Scer\UAS} under the control of Scer\GAL4^GMR.PU.

(Ambegaokar and Jackson, 2011)

Complementation and Rescue Data

Fails to complement

Dlic^G0065

(Mische et al., 2008)

Rescued by

Dlic^G0190 is rescued by Dlic^+tMa

(Mische et al., 2008)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Kyoto

111861

w^67c23 P{lacW}Dlic^G0190 P{neoFRT}19A/FM7c; P{ey-FLP.N}5

Notes on Origin

Discoverer

Comments

P{lacW} not verified as causing the lethality.

(Schäfer et al., 1999.8.12)

Precise excision of the insertion reverts the lethal phenotype.

(Mische et al., 2008)

External Crossreferences and Linkouts ( 1 )

Crossreferences

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

AJ426856

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

Dlic2^G0190

(Ambegaokar and Jackson, 2011)

Dlic^G0190

(Popodi et al., 2010-, Mische et al., 2008)

dlic2^G0190

(Simonsen et al., 2007)

l(1)G0190

(Peter et al., 2002)

l(1)G0190^G0190

(Schäfer et al., 1999.8.12)

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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