A Database of Drosophila Genes & Genomes

FB2013_03, released May 7th, 2013
 

Allele Dmel\SmD3k09037

General Information
SymbolDmel\SmD3k09037SpeciesD. melanogaster
NameFlyBase IDFBal0100401
Feature typealleleAssociated geneDmel\SmD3
Also Known Asl(2)k090-37
Allele class
MutagenP-element activity
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Description
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FB2013_03
FB2013_02
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Allele class
Mutagen
Mutations Mapped to the Genome
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Caused by insertion
Cytology
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Statement
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Homozygous 12-day old larvae show overgrowth of the brain, hematopoietic organs and imaginal discs and a reduction in size of the salivary glands. The size of the digestive tract is nearly normal.
Lethality occurs during third instar larval or pupal stages. Mutants exhibit visible disc abnormalities: very small or no discs. Clones cannot be induced in wild type discs.
Elongated brain hemispheres, slightly abnormal folding in discs, lymph gland retains lobular structure.
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The level of SmD3 transcript is strongly reduced in P{lacW}SmD3k09037 homozygotes compared to wild type, whereas Oda expression remains essentially unaffected. The P{lacW}SmD3k09037 insertion appears to affect only SmD3 function and not Oda function (despite being within an Oda intron), since the lethality of P{lacW}SmD3k09037 homozygotes is fully rescued by the P{SmD3.+t2.3} construct which contains the complete SmD3 gene. Complements: OdaEP2104.
P-element excision demonstrates the insertion to be the cause of lethality.
This allele was listed in the BDGP database as a lethal or sterile line during the period 1994-1999, but was discarded from the gene disruption project prior to the summary publication (FBrf0111489). Reasons for excluding lines from the collection described in FBrf0111489 include presence of more than one P insertion on the mutant chromosome, separation of lethality (or sterility) from the location of the insertion, and loss of lethality (or sterility) from the stock. Further information is available from http://www.fruitfly.org/bfd/ and from Dr. Spradling (spradling@mail1.ciwemb.edu).
 
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hide Synonyms & Secondary IDs ( 5 )
Reported As
Symbol Synonym
gufk09037
 
l(2)k09037k09037
 
SmD3k09037
 
Name Synonym
Secondary FlyBase IDs
hide References ( 5 )
Research paper
Schenkel et al., 2002, Genetics 161(2): 763--772
P elements inserted in the vicinity of or within the Drosophila snRNP SmD3 gene nested in the first intron of the Ornithine decarboxylase antizyme gene affect only the expression of SmD3. [FBrf0149027]
Roch et al., 1998, Mol. Gen. Genet. 257(2): 103--112
Screening of larval/pupal P-element induced lethals on the second chromosome in Drosophila melanogaster: clonal analysis and morphology of imaginal discs. [FBrf0100624]
Torok et al., 1993, Genetics 135(1): 71--80
P-lacW insertional mutagenesis on the second chromosome of Drosophila melanogaster: isolation of lethals with different overgrowth phenotypes. [FBrf0058618]
Personal communication to FlyBase
BDGP Project Members, 1994-1999, BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project. (Computer file)
BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project. (Computer file) [FBrf0067338]
Abstract
Schenkel et al., 1999, Europ. Dros. Res. Conf. 16: 214
Down-regulation of the expression of the spliceosome core protein SmD3 gene results in tissue overgrowth. [FBrf0110736]