Allele Dmel\SmD3k09037
| General Information | |||
|---|---|---|---|
| Symbol | Dmel\SmD3k09037 | Species | D. melanogaster |
| Name | FlyBase ID | FBal0100401 | |
| Feature type | allele | Created / Updated | 2006-05-14/2006-05-14 |
| Associated gene | Dmel\SmD3 | ||
| Allele class | |||
| Mutagen | P-element activity | ||
Nature of the Allele
| |||
| Allele class | |||
| Mutagen | |||
| Mapped Features and Mutations | |||
Type Symbol & Location Additional Notes References | |||
| Associated Sequence Data | |||
| DDBJ
/
EMBL / GenBank | DNA sequence Protein sequence Name | ||
| UniProtKB/Swiss-Prot | |||
| UniProtKB/TrEMBL | |||
| Progenitor genotype | |||
| Nature of the lesion | Statement Reference | ||
| Assay mode | |||
| Caused by insertion | |||
| Cytology | |||
Phenotypic Data
| |||
Phenotypic Class
| |||
Phenotype Manifest In
| |||
Detailed Description
| |||
Statement Reference Elongated brain hemispheres, slightly abnormal folding in discs, lymph gland retains lobular structure. Lethality occurs during third instar larval or pupal stages. Mutants exhibit visible disc abnormalities: very small or no discs. Clones cannot be induced in wild type discs. Homozygous 12-day old larvae show overgrowth of the brain, hematopoietic organs and imaginal discs and a reduction in size of the salivary glands. The size of the digestive tract is nearly normal. | |||
Interactions
| |||
Phenotypic Class
| |||
Phenotype Manifest In
| |||
Additional Comments
| |||
Genetic Interactions
| |||
Statement Reference | |||
Xenogenetic Interactions
| |||
Statement Reference | |||
Complementation & Rescue Data
| |||
| Fails to complement | |||
| Rescued by | SmD3k09037 is rescued by SmD3+t2.3 | ||
| Comments | |||
Stocks
( 0 ) | |||
Notes on Origin
| |||
| Discoverer | |||
Comments
| |||
This allele was listed in the BDGP database as a lethal or sterile line during the period 1994-1999, but was discarded from the gene disruption project prior to the summary publication (FBrf0111489). Reasons for excluding lines from the collection described in FBrf0111489 include presence of more than one P insertion on the mutant chromosome, separation of lethality (or sterility) from the location of the insertion, and loss of lethality (or sterility) from the stock. Further information is available from http://www.fruitfly.org/bfd/ and from Dr. Spradling (spradling@mail1.ciwemb.edu). P-element excision demonstrates the insertion to be the cause of lethality. The level of SmD3 transcript is strongly reduced in P{lacW}SmD3k09037 homozygotes compared to wild type, whereas Oda expression remains essentially unaffected. The P{lacW}SmD3k09037 insertion appears to affect only SmD3 function and not Oda function (despite being within an Oda intron), since the lethality of P{lacW}SmD3k09037 homozygotes is fully rescued by the P{SmD3.+t2.3} construct which contains the complete SmD3 gene. Complements: OdaEP2104. | |||
Synonyms & Secondary IDs
( 5 ) | |||
| Reported As | |||
| Symbol Synonym | 90/37 gufk09037 l(2)k090-37 l(2)k09037k09037 SmD3k09037 | ||
| Name Synonym | |||
| Secondary FlyBase IDs | |||
References
( 5 ) | |||
| Research paper |
| ||
| Abstract |
| ||
| Computer file |
| ||
Nature of the Allele