Allele Dmel\SmD3^k09037

General Information
Symbol	Dmel\SmD3^k09037	Species	D. melanogaster
Name		FlyBase ID	FBal0100401
Feature type	allele	Associated gene	Dmel\SmD3
Also Known As	l(2)k090-37

Allele class
Mutagen	P-element activity
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen	P-element activity (Torok et al., 1993, BDGP Project Members, 1994-1999, Roch et al., 1998, Schenkel et al., 1999, Schenkel et al., 2002)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Caused by insertion	P{lacW}SmD3^k09037 (Schenkel et al., 1999, BDGP Project Members, 1994-1999, Torok et al., 1993, Schenkel et al., 2002, Roch et al., 1998)
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| larval stage (with SmD3^EP2176), with Scer\GAL4[-]: (Schenkel et al., 2002) lethal \| larval stage (with SmD3^k09540) (Schenkel et al., 2002) lethal \| larval stage (with SmD3^k11803) (Schenkel et al., 2002) lethal \| larval stage (with SmD3^k13107) (Schenkel et al., 2002) lethal \| larval stage (with SmD3^k15401) (Schenkel et al., 2002) lethal \| larval stage (with SmD3^lex47) (Schenkel et al., 2002) lethal \| larval stage (with SmD3^ΔLR51) (Schenkel et al., 2002) lethal \| larval stage \| recessive (Schenkel et al., 2002) lethal \| pupal stage (Torok et al., 1993) lethal \| recessive (Roch et al., 1998)
Phenotype Manifest In
	embryonic/larval brain (Torok et al., 1993) embryonic/larval lymph gland (Schenkel et al., 2002, Torok et al., 1993) embryonic/larval optic lobe (Schenkel et al., 2002) embryonic/larval salivary gland (Schenkel et al., 2002) haltere disc (Schenkel et al., 2002) imaginal disc (Schenkel et al., 2002, Roch et al., 1998) ventral thoracic disc (Schenkel et al., 2002) wing disc (Schenkel et al., 2002)
Detailed Description
	Statement Reference Homozygous 12-day old larvae show overgrowth of the brain, hematopoietic organs and imaginal discs and a reduction in size of the salivary glands. The size of the digestive tract is nearly normal. (Schenkel et al., 2002) Lethality occurs during third instar larval or pupal stages. Mutants exhibit visible disc abnormalities: very small or no discs. Clones cannot be induced in wild type discs. (Roch et al., 1998) Elongated brain hemispheres, slightly abnormal folding in discs, lymph gland retains lobular structure. (Torok et al., 1993)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Fails to complement	SmD3^EP2176 (Schenkel et al., 2002) SmD3^k09540 (Schenkel et al., 2002) SmD3^k11803 (Schenkel et al., 2002) SmD3^k13107 (Schenkel et al., 2002) SmD3^k15401 (Schenkel et al., 2002) SmD3^lex47 (Schenkel et al., 2002) SmD3^ΔLR51 (Schenkel et al., 2002)
Rescued by	SmD3^k09037 is rescued by SmD3^+t2.3 (Schenkel et al., 2002)
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

Comments
	The level of SmD3 transcript is strongly reduced in P{lacW}SmD3^k09037 homozygotes compared to wild type, whereas Oda expression remains essentially unaffected. The P{lacW}SmD3^k09037 insertion appears to affect only SmD3 function and not Oda function (despite being within an Oda intron), since the lethality of P{lacW}SmD3^k09037 homozygotes is fully rescued by the P{SmD3.+t2.3} construct which contains the complete SmD3 gene. Complements: Oda^EP2104. (Schenkel et al., 2002) P-element excision demonstrates the insertion to be the cause of lethality. (Torok et al., 1993) This allele was listed in the BDGP database as a lethal or sterile line during the period 1994-1999, but was discarded from the gene disruption project prior to the summary publication (FBrf0111489). Reasons for excluding lines from the collection described in FBrf0111489 include presence of more than one P insertion on the mutant chromosome, separation of lethality (or sterility) from the location of the insertion, and loss of lethality (or sterility) from the stock. Further information is available from http://www.fruitfly.org/bfd/ and from Dr. Spradling (spradling@mail1.ciwemb.edu).
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 5 )
Reported As
Symbol Synonym	90/37 (Roch et al., 1998) guf^k09037 l(2)k090-37 (Schenkel et al., 2002, Schenkel et al., 1999) l(2)k09037^k09037 SmD3^k09037
Name Synonym
Secondary FlyBase IDs

References ( 5 )
Research paper	Schenkel et al., 2002, Genetics 161(2): 763--772 P elements inserted in the vicinity of or within the Drosophila snRNP SmD3 gene nested in the first intron of the Ornithine decarboxylase antizyme gene affect only the expression of SmD3. [FBrf0149027] Roch et al., 1998, Mol. Gen. Genet. 257(2): 103--112 Screening of larval/pupal P-element induced lethals on the second chromosome in Drosophila melanogaster: clonal analysis and morphology of imaginal discs. [FBrf0100624] Torok et al., 1993, Genetics 135(1): 71--80 P-lacW insertional mutagenesis on the second chromosome of Drosophila melanogaster: isolation of lethals with different overgrowth phenotypes. [FBrf0058618]
Personal communication to FlyBase	BDGP Project Members, 1994-1999, BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project. (Computer file) BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project. (Computer file) [FBrf0067338]
Abstract	Schenkel et al., 1999, Europ. Dros. Res. Conf. 16: 214 Down-regulation of the expression of the spliceosome core protein SmD3 gene results in tissue overgrowth. [FBrf0110736]

Allele Dmel\SmD3k09037

Allele Dmel\SmD3^k09037