Allele Dmel\Plc21C^A

General Information
Symbol	Dmel\Plc21C^A	Species	D. melanogaster
Name		FlyBase ID	FBal0100414
Feature type	allele	Associated gene	Dmel\Plc21C

Allele class
Mutagen	P-element activity
Recent Updates
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	P-element activity (Weinkove et al., 1999)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype	P{lacW}Plc21C^k31911 (Weinkove et al., 1999)
Nature of the lesion	Statement Reference Proximal break of Df(2L)Pi3K21B-A falls in the first intron of Plc21C, at the site of the P{lacW} insertion in the progenitor chromosome. (Weinkove et al., 1999)
Caused by aberration	Df(2L)Pi3K21B-A (Weinkove et al., 1999)
Cytology
Phenotypic Data
Phenotypic Class
	neurophysiology defective (with Plc21C^k31911) (Kain et al., 2008) neurophysiology defective \| dominant (Kain et al., 2008)
Phenotype Manifest In

Detailed Description
	Statement Reference The electroantennograms of Plc21C[A]/+ animals show a small but significant decrease in amplitude compared to controls in response to a number of odours (ethyl acetate, butanol, propionic acid, benzaldehyde and iso-amyl acetate). The electroantennograms of Plc21C[k31911]/Plc21C[A] animals show a significant decrease in amplitude compared to controls in response to a number of odours (ethyl acetate, butanol, propionic acid, benzaldehyde and iso-amyl acetate). (Kain et al., 2008)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement Reference Plc21C^A has neurophysiology defective \| dominant phenotype, enhanceable by Galpha49B[+]/Gαq^221c (Kain et al., 2008) Plc21C^A has neurophysiology defective \| dominant phenotype, enhanceable by Gα49B[+]/Gαq¹³⁷⁰ (Kain et al., 2008)
Enhancer of
Statement Reference Plc21C[+]/Plc21C^A is an enhancer of neurophysiology defective \| dominant phenotype of Gαq^221c (Kain et al., 2008) Plc21C[+]/Plc21C^A is an enhancer of neurophysiology defective \| dominant phenotype of Gαq¹³⁷⁰ (Kain et al., 2008)
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference The electroantennograms of Gα49B[221c]/Plc21C[A] and Gα49B[1370]/Plc21C[A] double heterozygous animals show a significant decrease in amplitude compared to controls in response to a number of odours (ethyl acetate, butanol, propionic acid, benzaldehyde and iso-amyl acetate) and the reduction in the double heterozygotes is significantly greater than that expected to arise from a mere additive effect of the single heterozygous phenotypes. (Kain et al., 2008)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	Plc21C^A plc21C^p60A (Kain et al., 2008)
Name Synonym
Secondary FlyBase IDs

References ( 2 )
Research paper	Kain et al., 2008, J. Neurosci. 28(18): 4745--4755 Reduced odor responses from antennal neurons of G(q)alpha, phospholipase Cbeta, and rdgA mutants in Drosophila support a role for a phospholipid intermediate in insect olfactory transduction. [FBrf0204625] Weinkove et al., 1999, Curr. Biol. 9(18): 1019--1029 Regulation of imaginal disc cell size, cell number and organ size by Drosophila class I(A) phosphoinositide 3-kinase and its adaptor. [FBrf0111517]

Allele Dmel\Plc21CA

Allele Dmel\Plc21C^A