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General Information
Symbol
Dmel\slou286
Species
D. melanogaster
Name
FlyBase ID
FBal0101153
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

C21556201T

Reported nucleotide change:
Amino acid change:

Q220term | slou-PA; Q220term | slou-PB

Reported amino acid change:

Q220term

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: ?220term.

Nucleotide substitution: C983T.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

The pattern of somatic ventral muscles is severely disrupted in mutant embryos, and muscles 25 and 29 are completely absent. The syncytial fibres at the normal positions of muscles 26 and 27 have aberrant and variable morphologies, although their insertion sites and sizes are still reminiscent of the two muscles. It cannot be determined whether they form two separate or one large syncytium in each segment. The progenitors of muscles 26 and 27 appear to form normally. Disruptions are also seen in lateral and dorsolateral areas of the body wall musculature; muscle 5 is absent, whereas muscle 8 appears to be duplicated in each of the segments. At the normal positions of muscles 11 and 18, there is one syncytium (or perhaps two closely associated ones) with a morphology that does not resemble either of these two dorsolateral muscles, although it shares their ventral attachment site. The pattern of dorsal somatic muscles is normal. Additional lateral and ventral adult muscle precursor cells are formed. Most homozygotes or hemizygotes die during different stages of development, but approximately 10% survive to adulthood under favourable conditions. These escapers are very weak, unable to reproduce and have a short life span. The flies show sluggish movements and the majority have outspread, upheld or drooping wing postures. Freshly eclosed adult escapers have a duplicated muscle 8 in every abdominal hemisegment. The ventral and lateral adult muscle groups have essentially the same number of muscle fibres as in wild-type flies (despite the supernumerary lateral and ventral adult muscle precursor cells that are formed in embryos). The flies have a full complement of direct and indirect flight muscles and their overall morphology closely resembles that of wild-type flies.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (2)