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General Information
Symbol
Dmel\pblΔDH497-549.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0101238
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-PblΔDH497-549
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

The 1.94kb EcoR1-Sca1 and the 1.04kb Spe1(filled in)-EcoR1 fragments of the 1A pbl cDNA are expressed under the control of UASt sequences. Amino acids 497-549, at the C terminal of the DH domain, are removed.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of pblΔDH497-549.Scer\UAS under the control of Scer\GAL4GMR.PF results in an obvious roughening of the adult ommatidial array.

When pblΔDH497-549.Scer\UAS is driven by Scer\GAL4Bx-MS1096 a multiple wing hair phenotype is seen. Nuclei in the wing are heterogeneous in size and, and the multiple wing hair phenotype is a consequence of a failure in cytokinesis.

pblΔDH497-549.Scer\UAS; Scer\GAL4en-e16E flies have only subtle morphological defects in the posterior compartment of their wings.

Overexpression of pblΔDH497-549.Scer\UAS in the eye driven by Scer\GAL4GMR.PF, induces disruption of the ordered structure of the eye, with fusions of ommatidia, loss of many bristles, variation in numbers of rhabdomeres per ommatidium and decrease in the number of pigment cells. This phenotype is dominantly enhanced by mutations in pbl.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference
NOT Enhanced by
Statement
Reference
Suppressed by
Statement
Reference
NOT suppressed by
Statement
Reference
Other
Phenotype Manifest In
Enhanced by
Statement
Reference
NOT Enhanced by
Statement
Reference
Suppressed by
Statement
Reference
NOT suppressed by
Statement
Reference
Other
Additional Comments
Genetic Interactions
Statement
Reference

The addition of CycB32 suppresses the pblΔDH497-549.Scer\UAS wing hair phenotype in a dose dependant manner.

The eye phenotype caused by expression of pblΔDH497-549.Scer\UAS by Scer\GAL4GMR.PF is dominantly enhanced by Rho172R and dia2.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

pblΔDH497-549.Scer\UAS; Scer\GAL4prd.RG1 fails to significantly rescue the formation of eve positive clusters of dorsal mesodermal cells in stage 11 pbl2/pbl3 embryos.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
pblΔDH497-549.Scer\UAS
pblΔDH497-549.UAS
Name Synonyms
Secondary FlyBase IDs
    References (5)