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General Information
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| Symbol | Dmel\pblΔDH497-549.Scer\UAS | Species | D. melanogaster |
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| Name | | FlyBase ID | FBal0101238 |
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| Feature type | allele | Associated gene | Dmel\pbl |
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| Allele class | |
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| Mutagen | in vitro construct - regulatory fusion, in vitro construct - deletion |
Recent Updates
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| Description |
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It currently only tracks new links between this FlyBase report and other
FlyBase data classes (e.g. genes, references, stocks) or controlled
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| FB2013_03 |
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| FB2013_02 |
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| All updates |
Click here to see a list of all updates to this record from FB2010_08 and on.
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Nature of the Allele
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| Allele class | |
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| Mutagen | |
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| Mutations Mapped to the Genome |
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| Associated Sequence Data |
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DDBJ
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EMBL
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GenBank |
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| UniProtKB/Swiss-Prot | |
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| UniProtKB/TrEMBL | |
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| Progenitor genotype | |
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| Nature of the lesion | Construct: The 1.94kb EcoR1-Sca1 and the 1.04kb Spe1(filled in)-EcoR1 fragments of the 1A pbl cDNA are expressed under the control of Scer\UAS sequences. Amino acids 497-549, at the C terminal of the DH domain, are removed. |
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| Carried in construct | |
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| Cytology | |
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Phenotypic Data
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Phenotypic Class
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Phenotype Manifest In
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Detailed Description
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| When pblΔDH497-549.Scer\UAS is driven by Scer\GAL4Bx-MS1096 a multiple wing hair phenotype is seen. Nuclei in the wing are heterogeneous in size and, and the multiple wing hair phenotype is a consequence of a failure in cytokinesis. Overexpression of pblΔDH497-549.Scer\UAS in the eye driven by Scer\GAL4GMR.PF, induces disruption of the ordered structure of the eye, with fusions of ommatidia, loss of many bristles, variation in numbers of rhabdomeres per ommatidium and decrease in the number of pigment cells. This phenotype is dominantly enhanced by mutations in pbl. |
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External Data
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Interactions
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Phenotypic Class
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NOT suppressed by |
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Other |
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Phenotype Manifest In
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NOT Enhanced by |
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NOT suppressed by |
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Other |
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Additional Comments
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Genetic Interactions
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Xenogenetic Interactions
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Complementation & Rescue Data
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| Fails to rescue | |
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| Comments | |
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Stocks
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Notes on Origin
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Discoverer
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External Crossreferences & Linkouts
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Synonyms & Secondary IDs
( 2 ) |
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| Reported As |
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| Secondary FlyBase IDs |
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References
( 5 ) |
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| Research paper | - Gregory et al., 2007, Fly 1(1): 13--22
- A Drosophila overexpression screen for modifiers of Rho signalling in cytokinesis. [FBrf0199094]
- Smallhorn et al., 2004, Development 131(11): 2641--2651
- The epithelial-mesenchymal transition of the Drosophila mesoderm requires the Rho GTP exchange factor Pebble. [FBrf0179446]
- Echard and O'Farrell, 2003, Curr. Biol. 13(5): 373--383
- The degradation of two mitotic cyclins contributes to the timing of cytokinesis. [FBrf0158812]
- Somers and Saint, 2003, Dev. Cell 4(1): 29--39
- A RhoGEF and Rho family GTPase-activating protein complex links the contractile ring to cortical microtubules at the onset of cytokinesis. [FBrf0158856]
- Prokopenko et al., 1999, Genes Dev. 13(17): 2301--2314
- A putative exchange factor for rho1 GTPase is required for initiation of cytokinesis in Drosophila. [FBrf0111464]
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