Open Close
General Information
Symbol
Dmel\E(spl)m4-BFMUAS.cAa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Apidianakis
FlyBase ID
FBal0101268
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-m4
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

The complete E(spl)m4-BFM cDNA is under the control of UASt sequences.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In

dorsal row & sensory mother cell, with Scer\GAL4ap-md544

Detailed Description
Statement
Reference

No extra neuroblasts are seen when E(spl)m4-BFMScer\UAS.cAa is expressed under the control of Scer\GAL4wor.PA or Scer\GAL4elav.PU.

Expression of m4Scer\UAS.cAa under the control of Scer\GAL4ey.PB has no effect on either eye or antenna disc development.

Expression of m4Scer\UAS.cAa when driven by Scer\GAL4bi-omb-Gal4 in the wing disc leads to an increase in the numbers of sensory organ precursors seen.

Flies with m4Scer\UAS.cAa under the control of Scer\GAL4ptc-559.1, Scer\GAL4sca-T3, Scer\GAL4455.2, Scer\GAL4pnr-MD237 or Scer\GAL4ap-md544, show duplications of sensillum campaniformium, macrochaetae and microchaetae in their normal locations that are frequently tufted together. No effects are seen in the wing. Flies with m4Scer\UAS.cAa under the control of Scer\GAL4ptc-559.1, show duplications of the scutellar bristles and the anterior cross-vein campaniform sensilla in their normal locations. If two copies of m4Scer\UAS.cAa are present the number of bristles increases yet more. Flies with m4Scer\UAS.cAa under the control of Scer\GAL4455.2, show duplications of the scutellar bristles. Flies with m4Scer\UAS.cAa under the control of Scer\GAL432B or Scer\GAL4bi-md653 showed no wing pattern aberrations. m4Scer\UAS.cAa, when driven by Scer\GAL4ap-md544, creates clusters of wing margin sensory organ precursors (SOPs) in their normal locations in the dorsal row, where there would only be single SOPs in wild-type. Over commitment of the ACV and L3 precursors of campaniform sensilla are also seen. The N/numb mediated asymmetric divisions in the SOP lineage are not affected. In somatic clones where m4Scer\UAS.cAa is over-expressed under the control of Scer\GAL4Ubx.PdC, clustered microchaetae are seen, even at the clone boundary, suggesting the effect is acting at the level of signal reception.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhanced by
NOT Enhanced by
Suppressed by
NOT suppressed by
NOT Suppressor of
Additional Comments
Genetic Interactions
Statement
Reference

Scer\UAS.cAa enhances the number of extra scutellar bristles caused by expression of m4Scer\UAS.cAa under the control of Scer\GAL4ptc-559.1 m4Scer\UAS.cAa driven by Scer\GAL4ptc-559.1 cannot restore scutellar bristles to E(spl)Scer\UAS.cLa, HLHm7Scer\UAS.cdCa, HLHmδScer\UAS.cdCa or HLHmβScer\UAS.cdCa The scutellar bristle duplication phenotype caused by expression of m4Scer\UAS.cAa under the control of Scer\GAL4455.2 can be suppressed by a single copy of HLHm7Scer\UAS.cdCa. m4Scer\UAS.cAa, when driven by Scer\GAL4ap-md544 in a Df(1)sc10-1 background, does not restore any chaetae lost in this deficiency. The presence of NAx-1 partially suppresses the supernumerary scutellar bristle phenotype seen in m4Scer\UAS.cAa when driven by Scer\GAL4455.2. The presence of H2 partially suppresses the supernumerary scutellar bristle phenotype seen in m4Scer\UAS.cAa when driven by Scer\GAL4ptc-559.1. The presence of Df(3R)Dl-BX6, neurA101, bib2 or mami511 has no significant effect on the supernumerary scutellar bristle phenotype seen in m4Scer\UAS.cAa when driven by Scer\GAL4ptc-559.1. The presence of Df(3R)grob32.2 enhances the supernumerary scutellar bristle phenotype seen in m4Scer\UAS.cAa when driven by Scer\GAL4ptc-559.1.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Symbol Synonym
E(spl)m4-BFMScer\UAS.cAa
E(spl)m4-BFMUAS.cAa
m4Scer\UAS.cAa
Name Synonyms
Saccharomyces cerevisiae UAS construct a of Apidianakis
Secondary FlyBase IDs
    References (8)