FlyBase Allele Report: Dmel\stan[E45]

General Information

Symbol

Dmel\stan^E45

Species

D. melanogaster

Name

FlyBase ID

FBal0101422

Feature type

allele

Associated gene

Dmel\stan

Associated Insertion(s)

Carried in Construct

Also Known As

fmi^E45

Key Links

Genomic Maps

JBrowse

Allele class

loss of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

loss of function allele

(Usui et al., 1999)

Mutagen

ethyl methanesulfonate

(Usui et al., 1999)

Progenitor genotype

Cytology

Description

Amino acid replacement: V1849D.

(Usui et al., 1999)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2R:10,712,142..10,712,142 [+]

Nucleotide change:

T10712142A

Amino acid change:

Reported amino acid change:

V1849D

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Usui et al., 1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal planar polarity | recessive

(Usui et al., 1999)

abnormal planar polarity | somatic clone (with stan^E59)

(Strutt et al., 2002)

lethal - all die during embryonic stage | recessive

(Usui et al., 1999)

some die during embryonic stage | recessive

(Usui et al., 1999)

visible (with stan^E59), with Scer\GAL4^insc-Mz1407, stan^UAS.cUa

(Usui et al., 1999)

Phenotype Manifest In

2nd posterior cell & wing hair

(Usui et al., 1999)

dendrite | dorsal | embryonic stage

(Gao et al., 1999)

eye photoreceptor cell | somatic clone (with stan^E59)

(Strutt et al., 2002)

larval longitudinal connective

(Usui et al., 1999)

macrochaeta

(Usui et al., 1999)

ommatidium

(Usui et al., 1999)

ommatidium | somatic clone (with stan^E59)

(Strutt et al., 2002)

wing hair

(Usui et al., 1999)

Detailed Description

Statement

Reference

stan^E59/stan^E45, stan^arm.EGFP individuals do not exhibit wing trichome orientation defects.

(Strutt et al., 2016)

Mutants show no significant disruption of ovarian morphology.

(Cohen et al., 2002)

36.8% of ommatidia in stan^E45/stan^E59 mutant somatic clones in the eye are normal. 20.2% have rotated ommatidia, 26.1% have chirality defects, 15.9% are achiral (1% unscorable).

(Strutt et al., 2002)

When trans-heterozygous with stan⁷², exhibits excessive dorsal branch outgrowth and misrouting in the dorsal cluster of embryonic dendrites.

(Gao et al., 1999)

Mutants show local disconnection of longitudinal axon fascicles in the central nervous system. stan^E45/stan^E59 mutants partially rescued by stan^Scer\UAS.cUa driven by Scer\GAL4¹⁴⁰⁷ have planar polarity defects in ommatidia, sensory bristles and wing hairs. In region D (2nd posterior cell) of the wing, hairs are deflected from the proximo-distal axis and oriented towards the posterior wing margin.

(Usui et al., 1999)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

stan^E45 is an enhancer of abnormal cell polarity phenotype of Scer\GAL4^hs.2sev, Vang^UAS.cWa

(Jenny et al., 2003)

stan^E45 is an enhancer of abnormal cell polarity phenotype of Scer\GAL4^hs.2sev, pk^sple.UAS

(Jenny et al., 2003)

NOT Enhancer of

Statement

Reference

stan^E45 is a non-enhancer of abnormal cell polarity phenotype of pk^pk.sev

(Jenny et al., 2003)

NOT Suppressor of

Statement

Reference

stan^E45 is a non-suppressor of abnormal cell polarity phenotype of pk^pk.sev

(Jenny et al., 2003)

Phenotype Manifest In

Enhancer of

Statement

Reference

stan^E45 is an enhancer of ommatidium phenotype of Scer\GAL4^hs.2sev, Vang^UAS.cWa

(Jenny et al., 2003)

stan^E45 is an enhancer of ommatidium phenotype of Scer\GAL4^hs.2sev, pk^sple.UAS

(Jenny et al., 2003)

NOT Enhancer of

Statement

Reference

stan^E45 is a non-enhancer of ommatidium phenotype of pk^pk.sev

(Jenny et al., 2003)

NOT Suppressor of

Statement

Reference

stan^E45 is a non-suppressor of ommatidium phenotype of pk^pk.sev

(Jenny et al., 2003)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescued by

stan^E45/stan^E59 is partially rescued by Scer\GAL4^insc-Mz1407/stan^UAS.cUa

(Usui et al., 1999)

Comments

The lethality and axonal defects seen in stan^E45/stan^E59 can be rescued by stan^Scer\UAS.cUa driven by Scer\GAL4¹⁴⁰⁷. This combination does not affect the planar polarity phenotype.

(Usui et al., 1999)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

fmi e45

(Chen and Clandinin, 2008)

fmi⁴⁵

(Axelrod, 2001)

fmi^E45

(Xu et al., 2020, Strutt et al., 2019, Thuveson et al., 2019, Kelly et al., 2016, Strutt et al., 2016, Kimura et al., 2006, Das et al., 2004, Jenny et al., 2003, Cohen et al., 2002, Strutt et al., 2002, Gao et al., 1999, Usui et al., 1999)

stan^E45

Name Synonyms

Secondary FlyBase IDs

References (14)

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