FB2025_05 , released December 11, 2025
Allele: Dmel\Lis-1unspecified
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General Information
Symbol
Dmel\Lis-1unspecified
Species
D. melanogaster
Name
FlyBase ID
FBal0101615
Feature type
allele
Associated gene
Dmel\Lis-1
Associated Insertion(s)
Carried in Construct
Also Known As
Lis1unspecified
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    FlyBase curator comment: this entry is used to capture phenotypic information when the particular allele (or allele combination) used by the author could not be determined but the context of the experiment suggests that the phenotype being described is some kind of loss of function.

    (FlyBase Curators, 2025-)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        In eggs laid by mutant mothers, germ-band extension is delayed with respect to wild-type, and does not extend as far anteriorly. At later stages the germ-band fails to extend completely and instead invaginates into the anterior of the embryo. The majority of these embryos fail to complete embryogenesis. Less than 5% differentiate a cuticle.

        (Lei and Warrior, 2000)

        Homozygous embryos hatch normally and first instar larvae are indistinguishable from their heterozygous siblings. The development of homozygotes is clearly retarded at the second larval instar stage and they die 5-6 days later without phenotypically entering the third larval instar stage.

        (Liu et al., 1999)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Other
        Statement
        Reference

        Df(3L)10H, Lis-1unspecified has macrochaeta phenotype

        (Lei and Warrior, 2000)

        Df(3L)10H, Lis-1unspecified has microchaeta & abdomen phenotype

        (Lei and Warrior, 2000)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        The addition of Df(3L)10H (lacking Dhc64C) to Lis-1unspecified transheterozygotes results in defects in scutellar and abdominal bristle morphology.

        (Lei and Warrior, 2000)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        Lis-1unspecified
        Lis1unspecified
        (Lei and Warrior, 2000, Liu et al., 1999)
        Name Synonyms
        Secondary FlyBase IDs
          References (3)