FlyBase Allele Report: Dmel\Axn[ΔRGS.UAS]

General Information

Symbol

Dmel\Axn^ΔRGS.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0101805

Feature type

allele

Associated gene

Dmel\Axn

Associated Insertion(s)

Carried in Construct

P{UAS-Axn.ΔRGS}

Key Links

Transgenic product class

inframe_deletion

(Willert et al., 1999)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

inframe_deletion

(Willert et al., 1999)

Mutagen

in vitro construct

(Willert et al., 1999)

Progenitor genotype

Carried in construct

P{UAS-Axn.ΔRGS}

Cytology

Description

Expression of the A1 form of Axn deleted for the RGS domain, amino acids 50 to 172, is governed by UASt regulatory sequences.

(Willert et al., 1999)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Axn

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

denticle, with Scer\GAL4^da.G32

(Willert et al., 1999)

embryonic epidermis, with Scer\GAL4^da.G32

(Willert et al., 1999)

wing, with Scer\GAL4^69B

(Willert et al., 1999)

Detailed Description

Statement

Reference

When expression is driven by Scer\GAL4^da.G32 a lawn of denticles results, reminiscent of the wg loss of function phenotype. When expression is driven by Scer\GAL4^69B the margin of the wing is notched, also reminiscent of a wg loss of function phenotype.

(Willert et al., 1999)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Axn^ΔRGS.UAS, Scer\GAL4^GMR.PU is a suppressor | partially of visible | adult stage phenotype of Hsap\RPS12^UAS.cKa, Scer\GAL4^GMR.PU

(Katanaev et al., 2020)

Axn^ΔRGS.UAS, Scer\GAL4^GMR.PU is a suppressor | partially of decreased size | adult stage phenotype of Hsap\RPS12^UAS.cKa, Scer\GAL4^GMR.PU

(Katanaev et al., 2020)

Other

Statement

Reference

Axn^ΔRGS.UAS, Mad^UAS.cNa, Scer\GAL4^sca-537.4 has visible phenotype

(Quijano et al., 2011)

Phenotype Manifest In

Suppressor of

Statement

Reference

Axn^ΔRGS.UAS, Scer\GAL4^GMR.PU is a suppressor | partially of eye phenotype of Hsap\RPS12^UAS.cKa, Scer\GAL4^GMR.PU

(Katanaev et al., 2020)

Other

Statement

Reference

Axn^ΔRGS.UAS, Mad^UAS.cNa, Scer\GAL4^sca-537.4 has wing margin bristle phenotype

(Quijano et al., 2011)

Additional Comments

Genetic Interactions

Statement

Reference

Flies co-expressing Axn^{ΔRGS.Scer\UAS} and Mad^Scer\UAS.cNa under the control of Scer\GAL4^sca-537.4 have normal wing sensilla with occasional small gaps in the row or stout mechanosensory bristles on the margin.

(Quijano et al., 2011)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Axn^{ΔRGS.Scer\UAS}

Axn^ΔRGS.UAS

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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