Allele Dmel\5-HT2^Scer\UAS.cCa

General Information
Symbol	Dmel\5-HT2^Scer\UAS.cCa	Species	D. melanogaster
Name	Saccharomyces cerevisiae UAS construct a of Colas	FlyBase ID	FBal0101838
Feature type	allele	Associated gene	Dmel\5-HT2

Allele class
Mutagen	in vitro construct - regulatory fusion
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen	in vitro construct - regulatory fusion (Colas et al., 1999)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Construct: Expression of full length 5-HT2 cDNA is governed by Scer\UAS regulatory sequences. (Colas et al., 1999)
Carried in construct	P{UAS-5-HT2.C} (Colas et al., 1999, Schaerlinger et al., 2007)
Cytology
Phenotypic Data
Phenotypic Class
	viable, with Scer\GAL4^Kr.PM (Colas et al., 1999) viable \| poor \| heat sensitive, with Scer\GAL4^Kr.PM (Colas et al., 1999)
Phenotype Manifest In
	gastrula embryo, with Scer\GAL4^Kr.PM (Colas et al., 1999)
Detailed Description
	Statement Reference Embryos expressing 5-HT2^Scer\UAS.cCa under the control of Scer\GAL4^Kr.PM show altered cell speed movements during germband extension, with ectodermal cells close to the pole cells showing increased cell speeds compared to equivalent cells in control embryos. (Schaerlinger et al., 2007) When expression is driven by Scer\GAL4^Kr.PM there are initially significant perturbations at the beginning of gastrulation, due to a mistiming in morphogenetic movements, which is compensated later in embryogenesis by an increase in rate of cell movement. Heat shocking increases the lethality. (Colas et al., 1999)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 1 )
Bloomington	24504 w¹¹¹⁸; P{UAS-5-HT2.C}2
Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	5-HT2^Scer\UAS.cCa
Name Synonym	Saccharomyces cerevisiae UAS construct a of Colas (Colas et al., 1999)
Secondary FlyBase IDs

References ( 2 )
Research paper	Schaerlinger et al., 2007, Dev. Dyn. 236(4): 991--999 Gain of affinity point mutation in the serotonin receptor gene 5-HT(2Dro) accelerates germband extension movements during Drosophila gastrulation. [FBrf0194099] Colas et al., 1999, Mech. Dev. 87(1-2): 77--91 Serotonin synchronises convergent extension of ectoderm with morphogenetic gastrulation movements in Drosophila. [FBrf0111346]

Allele Dmel\5-HT2Scer\UAS.cCa

Allele Dmel\5-HT2^Scer\UAS.cCa