Allele Dmel\w^Mcp.scs'.14

General Information
Symbol	Dmel\w^Mcp.scs'.14	Species	D. melanogaster
Name		FlyBase ID	FBal0102333
Feature type	allele	Associated gene	Dmel\w

Allele class
Mutagen	in vitro construct - regulatory fusion
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - regulatory fusion (Muller et al., 1999)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Construct: Contains the 2.8kb EcoRI Mcp fragment followed by the w enhancer upstream of the w^+mC minigene followed by the scs'^0.5 element. The proximal end of the Mcp fragment is closest to the w minigene. (Muller et al., 1999)
Carried in construct	P{Mcp-w#14} (Muller et al., 1999, Shanower et al., 2005)
Cytology
Phenotypic Data
Phenotypic Class
	eye color defective (Muller et al., 1999)
Phenotype Manifest In
	pigment cell (Muller et al., 1999)
Detailed Description
	Statement Reference Eye colour: P{Mcp-w#14} flies have similar or darker eye colours compared to P{w^RW+we}. Position effect variegation can sometimes be seen. Homozygotes do not generally have a darker eye colour than heterozygotes, and can sometimes be lighter in colour. Pairing-sensitive silencing the mini-w gene occurs in about 55% of transformant lines. (Muller et al., 1999)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement Reference w^Mcp.13, w^Mcp.scs'.14 has eye color defective phenotype, suppressible by pho[+]/pho¹ (Muller et al., 1999) w^Mcp.13, w^Mcp.scs'.14 has eye color defective phenotype, suppressible by pho[+]/pho^cv (Muller et al., 1999) w^Mcp.13, w^Mcp.scs'.14 has eye color defective phenotype, suppressible by Sce[+]/Sce¹ (Muller et al., 1999) w^Mcp.13, w^Mcp.scs'.14 has eye color defective phenotype, suppressible by Scm^ET50/Scm[+] (Muller et al., 1999) w^Mcp.scs'.13, w^Mcp.scs'.14 has eye color defective phenotype, suppressible by Pcl¹⁰/Pcl[+] (Muller et al., 1999) w^Mcp.scs'.13, w^Mcp.scs'.14 has eye color defective phenotype, suppressible by pho^cv/pho¹ (Muller et al., 1999) w^Mcp.scs'.13, w^Mcp.scs'.14 has eye color defective phenotype, suppressible by Sce[+]/Sce¹ (Muller et al., 1999) w^Mcp.scs'.13, w^Mcp.scs'.14 has eye color defective phenotype, suppressible by Scm^ET50/Scm[+] (Muller et al., 1999) w^Mcp.scs'.14 has eye color defective phenotype, suppressible by Pcl¹⁰/Pcl[+] (Muller et al., 1999) w^Mcp.scs'.14 has eye color defective phenotype, suppressible by Sce[+]/Sce¹ (Muller et al., 1999) w^Mcp.scs'.14 has eye color defective phenotype, suppressible by Scm^ET50/Scm[+] (Muller et al., 1999)
NOT suppressed by
Statement Reference w^Mcp.13, w^Mcp.scs'.14 has eye color defective phenotype, non-suppressible by Asx[+]/Asx¹ (Muller et al., 1999) w^Mcp.13, w^Mcp.scs'.14 has eye color defective phenotype, non-suppressible by Pc[+]/Pc² (Muller et al., 1999) w^Mcp.13, w^Mcp.scs'.14 has eye color defective phenotype, non-suppressible by Pcl¹⁰/Pcl[+] (Muller et al., 1999) w^Mcp.scs'.13, w^Mcp.scs'.14 has eye color defective phenotype, non-suppressible by Asx[+]/Asx¹ (Muller et al., 1999) w^Mcp.scs'.13, w^Mcp.scs'.14 has eye color defective phenotype, non-suppressible by Pc[+]/Pc² (Muller et al., 1999) w^Mcp.scs'.14 has eye color defective phenotype, non-suppressible by Asx¹ (Muller et al., 1999) w^Mcp.scs'.14 has eye color defective phenotype, non-suppressible by pho^cv/pho¹ (Muller et al., 1999)
Phenotype Manifest In
Suppressed by
Statement Reference w^Mcp.13, w^Mcp.scs'.14 has pigment cell phenotype, suppressible by pho[+]/pho¹ (Muller et al., 1999) w^Mcp.13, w^Mcp.scs'.14 has pigment cell phenotype, suppressible by pho[+]/pho^cv (Muller et al., 1999) w^Mcp.13, w^Mcp.scs'.14 has pigment cell phenotype, suppressible by Sce[+]/Sce¹ (Muller et al., 1999) w^Mcp.13, w^Mcp.scs'.14 has pigment cell phenotype, suppressible by Scm^ET50/Scm[+] (Muller et al., 1999) w^Mcp.scs'.13, w^Mcp.scs'.14 has pigment cell phenotype, suppressible by Pcl¹⁰/Pcl[+] (Muller et al., 1999) w^Mcp.scs'.13, w^Mcp.scs'.14 has pigment cell phenotype, suppressible by pho^cv/pho¹ (Muller et al., 1999) w^Mcp.scs'.13, w^Mcp.scs'.14 has pigment cell phenotype, suppressible by Sce[+]/Sce¹ (Muller et al., 1999) w^Mcp.scs'.13, w^Mcp.scs'.14 has pigment cell phenotype, suppressible by Scm^ET50/Scm[+] (Muller et al., 1999) w^Mcp.scs'.14 has pigment cell phenotype, suppressible by Pcl¹⁰/Pcl[+] (Muller et al., 1999) w^Mcp.scs'.14 has pigment cell phenotype, suppressible by Sce[+]/Sce¹ (Muller et al., 1999) w^Mcp.scs'.14 has pigment cell phenotype, suppressible by Scm^ET50/Scm[+] (Muller et al., 1999)
NOT suppressed by
Statement Reference w^Mcp.13, w^Mcp.scs'.14 has pigment cell phenotype, non-suppressible by Asx[+]/Asx¹ (Muller et al., 1999) w^Mcp.13, w^Mcp.scs'.14 has pigment cell phenotype, non-suppressible by Pc[+]/Pc² (Muller et al., 1999) w^Mcp.13, w^Mcp.scs'.14 has pigment cell phenotype, non-suppressible by Pcl¹⁰/Pcl[+] (Muller et al., 1999) w^Mcp.scs'.13, w^Mcp.scs'.14 has pigment cell phenotype, non-suppressible by Asx[+]/Asx¹ (Muller et al., 1999) w^Mcp.scs'.13, w^Mcp.scs'.14 has pigment cell phenotype, non-suppressible by Pc[+]/Pc² (Muller et al., 1999) w^Mcp.scs'.14 has pigment cell phenotype, non-suppressible by Asx¹ (Muller et al., 1999) w^Mcp.scs'.14 has pigment cell phenotype, non-suppressible by pho^cv/pho¹ (Muller et al., 1999)
Additional Comments
Genetic Interactions
Statement Reference The Pairing sensitive silencing effect seen in this allele is suppressed by heterozygous Sce¹, strongly suppressed by Scm^ET50 or Pcl¹⁰ and is unaffected by heterozygous Asx¹ or pho¹/pho^cv. The Pairing sensitive silencing effect seen in w^Mcp.scs'.14/w^Mcp.13 (P{Mcp-w#14}AP-2^stummelbein/+, P{Mcp-w#13}116/+) double insertions is suppressed by heterozygous Pcl¹⁰, strongly suppressed by heterozygous Scm^ET50, Sce¹ and pho¹/pho^cv, and is unaffected by heterozygous Asx¹ and Pc². (Muller et al., 1999) The Pairing sensitive silencing effect seen in this allele is suppressed by heterozygous Sce¹, strongly suppressed by Scm^ET50 or Pcl¹⁰ and is unaffected by heterozygous Asx¹ or pho¹/pho^cv. The Pairing sensitive silencing effect seen in w^Mcp.scs'.14/w^Mcp.scs'.13 (P{Mcp-w#14}AP-2^stummelbein/+, P{Mcp-w#13}116/+) double insertions is suppressed by heterozygous Pcl¹⁰, strongly suppressed by heterozygous Scm^ET50, Sce¹ and pho¹/pho^cv, and is unaffected by heterozygous Asx¹ and Pc². (Muller et al., 1999)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	w^Mcp.scs'.14
Name Synonym
Secondary FlyBase IDs

References ( 2 )
Research paper	Shanower et al., 2005, Genetics 169(1): 173--184 Characterization of the grappa gene, the Drosophila histone H3 lysine 79 methyltransferase. [FBrf0183454] Muller et al., 1999, Genetics 153(3): 1333--1356 The mcp element from the Drosophila melanogaster bithorax complex mediates long-distance regulatory interactions. [FBrf0111986]

Allele Dmel\wMcp.scs'.14

Allele Dmel\w^Mcp.scs'.14