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General Information
Symbol
Dmel\ttvUAS.Tag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0102367
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-ttv-myc, ttv-myc
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of ttv tagged with six copies of Tag:MYC.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of ttvScer\UAS.T:Hsap\MYC under the control of Scer\GAL4hh-Gal4 has little effect on germ cell migration in embryos.

Expression of ttvScer\UAS.T:Hsap\MYC under the control of Scer\GAL4ptc-559.1 results in germ cell migration defects in embryos; most of the germ cells are scattered in the posterior of the embryo and fail to coalesce with the somatic gonadal precursor cells. In a subset of embryos germ cells are clustered in the middle of the embryo, resulting in three germ cell clusters; two in the appropriate location on either side of the embryo in parasegment 10 and an additional cluster more anteriorly.

Expression of ttvScer\UAS.T:Hsap\MYC under the control of Scer\GAL4wg.PM results in germ cell migration defects in embryos.

Expression of ttvScer\UAS.T:Hsap\MYC under the control of Scer\GAL4elav.PLu results in germ cell migration defects in embryos. A significant number of germ cells that do not coalesce with the somatic gonadal precursor cells are found proximal to either the central nervous system or the ventral nerve cord.

Expression of ttvScer\UAS.T:Hsap\MYC under the control of Scer\GAL4h-1J3 results in a variety of germ cell migration defects in embryos. In approximately half the embryos, germ cells are seen in the vicinity of parasegments 10-12 but fail to coalesce with the somatic gonadal precursor cells. In approximately one quarter of the embryos germ cells are scattered widely throughout the embryos and in the remaining embryos there is a "pseudogonad"-like assembly in the middle of the embryo.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Partially rescues
Comments

Expression of ttvScer\UAS.T:Hsap\MYC with Scer\GAL4G14 leads to rescue of ttv00681b mutant larvae to adulthood or late pupal stages. The number of boutons per unit muscle area and bouton budding are increased to normal levels.

Expression of ttvScer\UAS.T:Hsap\MYC with Scer\GAL4elav-C155 improves viability of ttv00681b mutant larvae. The number of boutons per unit muscle area are increased to normal levels while bouton budding is elevated above wild-type levels.

Expression of ttvScer\UAS.T:Hsap\MYC with Scer\GAL4da.G32 fails to improve viability of ttv00681b mutant larvae but rescues the abnormally elevated mEJP frequency (but not the EJP amplitude) found in these larvae. The number of boutons relative to muscle area is significantly reduced compared with ttv00681b mutants.

ttvScer\UAS.T:Hsap\MYC with Scer\GAL4wg.PM completely rescues the cuticle phenotype of ttv00681b germ-line clone embryos.

Rescues the segment polarity phenotype of ttvunspecified embryos.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
ttvScer\UAS.T:Hsap\MYC
ttvUAS.Tag:MYC
Name Synonyms
Secondary FlyBase IDs
    References (7)