FlyBase Allele Report: Dmel\stan[3]

General Information

Symbol

Dmel\stan³

Species

D. melanogaster

Name

FlyBase ID

FBal0102374

Feature type

allele

Associated gene

Dmel\stan

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Chae et al., 1999)

Mutagen

Mutations Mapped to the Genome

Type

Location

Additional Notes

References

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Progenitor genotype

Cytology

Nature of the lesion

Statement

Reference

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal planar polarity | cell autonomous | recessive | somatic clone

(Chae et al., 1999)

abnormal planar polarity | recessive

(Chae et al., 1999)

viable

(Chae et al., 1999)

Phenotype Manifest In

trichome & abdominal tergite (with stan^E59)

(Casal et al., 2006)

wing cell | P-stage

(Classen et al., 2005)

wing hair

(Chae et al., 1999)

wing hair | precursor

(Chae et al., 1999)

wing hair | somatic clone

(Chae et al., 1999)

Detailed Description

Statement

Reference

stan³/stan^E59 flies have almost normal hair polarities in the tergite, apart from near the front and near the rear of the anterior compartment.

(Casal et al., 2006)

The hexagonal packing of intervein cells, which usually occurs between wing development stage P2B (when the first morphological signs of veins appear (FBrf0005070), and the middle of P2C (before hair formation (FBrf0005070)) is partially disrupted in stan³/stan³ flies.

(Classen et al., 2005)

Relatively strong polarity phenotype in the adult cuticle. Wing hairs show a stereotypical abnormal polarity pattern of the fz/in class. Homozygotes show relatively few multiple hair cells, similar to fz, dsh and pk mutants. During morphogenesis in pupal wings stan prehairs form at a relatively central location on the apical cells surface, as opposed to at the distal-most vertex as is characteristic of wild type cells. Somatic clones in the wing show cell autonomous wing hair polarity defects.

(Chae et al., 1999)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

stan³/stan³ is a suppressor of abnormal planar polarity | somatic clone | cell non-autonomous phenotype of fz¹⁵

(Lawrence et al., 2004)

stan³/stan³ is a suppressor of abnormal planar polarity | somatic clone phenotype of fz¹⁵

(Lawrence et al., 2004)

stan^E59/stan³ is a suppressor of abnormal planar polarity phenotype of Scer\GAL4^ptc-559.1, fz^UAS.cSa

(Lawrence et al., 2004)

Other

Statement

Reference

ds^unspecified, stan³ has abnormal planar polarity phenotype

(Casal et al., 2006)

Phenotype Manifest In

Enhancer of

Statement

Reference

stan[+]/stan³ is an enhancer of wing cell | adult stage | heat sensitive phenotype of shi¹

(Classen et al., 2005)

stan³ is an enhancer of wing hair phenotype of in^HC31

(Lee and Adler, 2002)

stan³ is an enhancer of wing hair phenotype of fz^hs.PP

(Chae et al., 1999)

Suppressor of

Statement

Reference

stan^E59/stan³ is a suppressor of trichome & adult abdomen phenotype of Scer\GAL4^ptc-559.1, fz^UAS.cSa

(Lawrence et al., 2004)

stan³/stan³ is a suppressor of trichome & abdomen | cell non-autonomous | somatic clone phenotype of fz¹⁵

(Lawrence et al., 2004)

stan³/stan³ is a suppressor of trichome & abdomen | somatic clone phenotype of fz¹⁵

(Lawrence et al., 2004)

stan³ is a suppressor of wing hair | somatic clone phenotype of fz²³

(Chae et al., 1999)

Other

Statement

Reference

ds^unspecified, stan³ has trichome & abdominal tergite phenotype

(Casal et al., 2006)

ds^unspecified, stan³ has chaeta & abdominal tergite phenotype

(Casal et al., 2006)

Additional Comments

Genetic Interactions

Statement

Reference

The reversal of cell polarity that is seen in cells posterior to clones in the anterior compartment of the dorsal epidermis of the adult abdomen (in the tergite) where the clones are expressing ds^{ecto.Scer\UAS} under the control of Scer\GAL4^αTub84B.PL is still seen if the clones are induced in a stan^- background (the cells within the clone are stan^E59/stan^E59 while the cells surrounding the clone are stan³/stan^E59).

Clones of cells in the anterior compartment of the dorsal epidermis of the adult abdomen (in the tergite) that are expressing fz^Scer\UAS.cUa under the control of Scer\GAL4^αTub84B.PL in a stan^- background (the cells within the clone are stan^E59/stan^E59 while the cells surrounding the clone are stan³/stan^E59) do not change the cell polarity of the stan³/stan^E59 cells surrounding the clone.

Clones of cells in the anterior compartment of the dorsal epidermis of the adult abdomen (in the tergite) that are co-expressing stan^Scer\UAS.cUa and fz^Scer\UAS.cUa under the control of Scer\GAL4^αTub84B.PL in a stan^- background (the cells within the clone are stan^E59/stan^E59 while the cells surrounding the clone are stan³/stan^E59) do not change the cell polarity of the stan³/stan^E59 cells surrounding the clone.

The reversal of cell polarity that is seen in cells anterior to clones in the anterior compartment of the dorsal epidermis of the adult abdomen (in the tergite) where the clones are expressing ft^Scer\UAS.cMa under the control of Scer\GAL4^αTub84B.PL is still seen if the clones are induced in a stan^- background (the cells within the clone are stan^E59/stan^E59 while the cells surrounding the clone are stan³/stan^E59).

Clones of cells in the anterior compartment of the dorsal epidermis of the adult abdomen (in the tergite) that are expressing fj^Scer\UAS.cZa under the control of Scer\GAL4^αTub84B.PL in a stan^- background (the cells within the clone are stan^E59/stan^E59 while the cells surrounding the clone are stan³/stan^E59) result in a reversal of cell polarity in cells anterior to the clone (hairs in front of the clone point forwards), as occurs in clones induced in a wild-type background.

The reversal of cell polarity that is seen in cells posterior to clones in the anterior compartment of the dorsal epidermis of the adult abdomen (in the tergite) where the clones are expressing ds^{ecto.Scer\UAS} under the control of Scer\GAL4^αTub84B.PL is still seen if the clones are induced in a fz^unspecified stan^- background (cells within the clone are stan^E59/stan^E59 while the cells surrounding the clone are stan³/stan^E59).

The reversal of cell polarity that is seen in cells anterior to clones in the anterior compartment of the dorsal epidermis of the adult abdomen (in the tergite) where the clones are expressing ft^Scer\UAS.cMa under the control of Scer\GAL4^αTub84B.PL is still seen if the clones are induced in a fz^unspecified stan^- background (cells within the clone are stan^E59/stan^E59 while the cells surrounding the clone are stan³/stan^E59).

Hair and bristle polarity is randomised throughout the tergite in ds^unspecified stan³/stan^E59 double mutant flies.

The reversal of cell polarity phenotype that is seen in cells posterior to clones in the anterior compartment of the dorsal epidermis of the adult abdomen (in the tergite) where the clones are doubly mutant for ptc¹⁶ and Df(2R)en^E is still seen if the clones are induced in a stan³/stan^E59 background, as occurs in clones induced a wild-type background.

The reversal of cell polarity phenotype that is seen in cells posterior to clones in the anterior compartment of the dorsal epidermis of the adult abdomen (in the tergite) where the clones are doubly mutant for ptc¹⁶ and Df(2R)en^E is not seen if the clones are induced in a ds^unspecified stan³/stan^E59 double mutant background instead of a wild-type background.

(Casal et al., 2006)

The formation of holes in wings due to temperature shift of shi¹/shi¹ animals during pupal stages is mildly enhanced by stan³/+,.

(Classen et al., 2005)

A stan³/stan³ background blocks planar repolarisation both inside and outside fz¹⁵ homozygous clones in the abdomen.

stan^E59/stan³ suppresses the planar repolarisation in the adult abdomen caused by fz^Scer\UAS.cSa; Scer\GAL4^ptc-559.1.

(Lawrence et al., 2004)

The domineering non-autonomy of the fz²³ clone phenotype is largely, but not completely, suppressed by stan³. stan³ completely blocks the ability of a gradient of fz expression to reorganize wing hair polarity. stan³ does not block the ability of fz^hs.PP to form multiple hairs, it rather enhances the fz^hs.PP multiple hair phenotype slightly.

(Chae et al., 1999)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Strong hypomorph.

(Chae et al., 1999)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

stan³

(Casal et al., 2006, Classen et al., 2005, Lawrence et al., 2004)

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

Open Close