Allele Dmel\spir^2F

General Information
Symbol	Dmel\spir^2F	Species	D. melanogaster
Name		FlyBase ID	FBal0102386
Feature type	allele	Associated gene	Dmel\spir
Also Known As	spire^2F

Map ( GBrowse )
Allele class
Mutagen
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen
Mutations Mapped to the Genome

Type Location Additional Notes References point mutation 2L:20,334,150..20,334,150 comment=Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. evidence=experimental pr_change=Q246\|spir-PD,Q246\|spir-PB,Q246@\|spir-PA reported_pr_change=Q246@ na_change=C20334150T (Wellington et al., 1999)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Amino acid replacement: Q246@. (Wellington et al., 1999)
Cytology
Phenotypic Data
Phenotypic Class

Phenotype Manifest In

Detailed Description
	Statement Reference
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressor of
Statement Reference spir[+]/spir^2F is a suppressor \| partially of embryonic head phenotype of mira^{αTub67C.T:Avic\GFP-m6} (Chang et al., 2011)
Additional Comments
Genetic Interactions
Statement Reference The bicaudal phenotype of embryos derived from mira[αTub67C.T:Avic\GFP-m6]/+ females is suppressed if the females are also heterozygous for spir[2F]. (Chang et al., 2011) Stage 7 oocytes from capu¹, spir^2F mothers undergo premature ooplasmic streaming. (Rosales-Nieves et al., 2006)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments	The loss of the actin mesh in the cytoplasm of stage 9 spir[1]/spir[2F] oocytes is rescued by expression of spir[RD.Scer\UAS.P\T.T:Avic\GFP] under the control of Scer\GAL4[nos.UTR.T:Hsim\VP16]. Ectopic actin mesh-like structures are also induced in the nurse cells in these animals. (Dahlgaard et al., 2007)
Stocks ( 1 )
Bloomington	8723 b¹ pr¹ spir^2F cn¹/CyO
Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	spir^2F spire^2F (Chang et al., 2011, Dahlgaard et al., 2007)
Name Synonym
Secondary FlyBase IDs

References ( 4 )
Research paper	Chang et al., 2011, Genetics 188(4): 883--896 Anterior-Posterior Axis Specification in Drosophila Oocytes: Identification of Novel bicoid and oskar mRNA Localization Factors. [FBrf0214626] Dahlgaard et al., 2007, Dev. Cell 13(4): 539--553 Capu and Spire assemble a cytoplasmic actin mesh that maintains microtubule organization in the Drosophila Oocyte. [FBrf0201859] Rosales-Nieves et al., 2006, Nat. Cell Biol. 8(4): 367--376 Coordination of microtubule and microfilament dynamics by Drosophila Rho1, Spire and Cappuccino. [FBrf0191267] Wellington et al., 1999, Development 126(23): 5267--5274 Spire contains actin binding domains and is related to ascidian posterior end mark-5. [FBrf0124975]

Allele Dmel\spir2F

Allele Dmel\spir^2F