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General Information
Symbol
Dmel\lola3.8.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0102519
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS sequences drive the expression of the lola 3.8 splice variant, subcloned as a 2kb EcoR1 fragment from lola cDNA 8.13.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

MARCM-mediated expression of lola3.8.Scer\UAS, using Scer\GAL4GH146, in neuroblasts or single cell clones does not result in detectable defects.

MARCM clones simultaneously mutant for lolae76 and lola3.8.Scer\UAS, induced using Scer\GAL4GH146, exhibit: i) cell loss and lack of dendritic extensions in adPN and lPN neuroblast clones; ii) a strong reduction of VA1lm and DA1 targeting in vPN clones, with the pan-AL neuron often showing little dendritic process elaboration and only rare innervation of much of the AL.

DL1 MARCM clones simultaneously mutant for lolae76 and lola3.8.Scer\UAS, induced using Scer\GAL4GH146 are variable, with half appearing normal . Axonal defects range from a failure to extend or elaborate branches in the LH to an increase in ectopic branching.

Overexpression of the lola 3.8 isoform, in lola3.8.Scer\UAS produces no detectable phenotype.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Fails to rescue
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
lola3.8.Scer\UAS
lola3.8.UAS
Name Synonyms
Secondary FlyBase IDs
    References (2)