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General Information
Symbol
Dmel\αSnapM4
Species
D. melanogaster
Name
FlyBase ID
FBal0102593
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
SNAPM4
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:

G20314690A

Reported nucleotide change:

G?A

Amino acid change:

A59T | alphaSnap-PA

Reported amino acid change:

A59T

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

A GCT to ACT alteration.

Amino acid replacement: A59T.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

SnapM4/Df(3L)rdgC-co2 adult escapers are uncoordinated, exhibit increasingly frequent seizures and typically die within 3 days of eclosion.

Electrophysiological studies of SnapM4/Df(3L)rdgC-co2 third instar larvae show that the excitatory junctional potential (EJP) amplitude is not significantly different from that measured in wild-type control larvae. However, the average amplitude of miniature EJPs is significantly increased and the quantal content is reduced in SnapM4/Df(3L)rdgC-co2 larvae. The neuromuscular junction morphology of these mutants is similar to that of control larvae.

Hemizygotes show early lethality.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference

alphaSnap[+]/αSnapM4 is an enhancer of visible phenotype of Hsap\CHMP2BIntron5.UAS, Scer\GAL4GMR.PU

Suppressor of
Phenotype Manifest In
Enhancer of
Statement
Reference

alphaSnap[+]/αSnapM4 is an enhancer of eye phenotype of Hsap\CHMP2BIntron5.UAS, Scer\GAL4GMR.PU

Suppressor of
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference

SnapM4/+ fully suppresses the increased excitatory junction potential (EJP) amplitude and decreased failure rate seen in Hsap\HD128Q.FL.Scer\UAS, Scer\GAL4elav-C155 animals at 0.25 mM Ca[2+].

SnapM4/+ suppresses the reduced number of rhabdomeres per ommatidium phenotype seen in Hsap\HD128Q.FL.Scer\UAS, Scer\GAL4GMR.PF animals at 20 days.

Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (8)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (7)