FlyBase Allele Report: Dmel\Trxr1[G0481]

General Information

Symbol

Dmel\Trxr1^G0481

Species

D. melanogaster

Name

FlyBase ID

FBal0102623

Feature type

allele

Associated gene

Dmel\Trxr1

Associated Insertion(s)

P{lacW}Trxr1^G0481

Carried in Construct

Also Known As

Trxr-1⁴⁸¹

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - genetic evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Missirlis et al., 2002)

Mutagen

P-element activity

(Schäfer et al., 1999.12.10)

Progenitor genotype

Associated Insertion(s)

P{lacW}Trxr1^G0481

Cytology

Description

P{lacW} insertion in exon 2, which contains the 5' untranslated region of the Trxr-1 mitochondrial transcript.

(Missirlis et al., 2002)

Allele components

Component

Use(s)

Inserted element

P{lacW}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

X:8,243,560..8,243,979 [+]

(Frost et al., 2014, Missirlis et al., 2002, Peter et al., 2002, Missirlis et al., 2001, Schäfer et al., 1999.12.10)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

AJ426769

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates neuronal ceroid lipofuscinosis

modeled by cathD¹

(Kuronen et al., 2009)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

pupa

(Green et al., 2016)

Detailed Description

Statement

Reference

Trxr-1^G0481 homozygotes are lethal, pupae are elongated and third instar larvae present no obvious muscle phenotype, as compared to controls.

(Green et al., 2016)

Homozygotes survive to the third larval instar, with 75% developing into pupae with 1 day of delay. About 20% eclose as normal looking adults, most of which die within 2-3 days of eclosion.

(Missirlis et al., 2002)

About 75% of hemizygotes dies as normal looking pharate adults or during eclosion. The life span of those flies that do eclose is severely reduced.

(Missirlis et al., 2001)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Trxr1^G0481 has lethal | recessive phenotype, enhanceable by Sod1ⁿ¹/Sod[+]

(Missirlis et al., 2001)

Trxr1^G0481 has lethal | recessive phenotype, enhanceable by Catⁿ¹/Cat[+]

(Missirlis et al., 2001)

Trxr1^G0481 has lethal | recessive phenotype, enhanceable by Hsap\SOD1^UAS.cPa/Scer\GAL4^Act5C.PI

(Missirlis et al., 2001)

Suppressed by

Statement

Reference

Trxr1^G0481 has lethal | recessive phenotype, suppressible | partially by Cat^UAS.cAa/Scer\GAL4^Act5C.PI

(Missirlis et al., 2001)

Phenotype Manifest In

Enhancer of

Statement

Reference

Trxr1^G0481/Trxr-1[+] is an enhancer of eye phenotype of cathD¹

(Kuronen et al., 2009)

Additional Comments

Genetic Interactions

Statement

Reference

A Trxr-1^G0481 mutant background enhances by more than 10-fold the level of vacuolar change in cathD¹ mutant retina.

(Kuronen et al., 2009)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Complements

Trxr1^Δ2

(Missirlis et al., 2002)

Trxr1^G0477

(Missirlis et al., 2002)

Rescued by

Trxr1^G0481 is rescued by Trxr1^cyto.UAS/Scer\GAL4^Act5C.PI

(Missirlis et al., 2002)

Trxr1^G0481 is rescued by Trxr1^cyto.UAS/Scer\GAL4^Act5C.PI

(Missirlis et al., 2001)

Not rescued by

Trxr1^G0481 is not rescued by Scer\GAL4^Act5C.PI/Trxr1^mito.UAS

(Missirlis et al., 2002)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

10134

w^67c23 P{lacW}Trxr1^G0481/FM7c

Notes on Origin

Discoverer

Comments

P{lacW} not verified as causing the lethality.

(Schäfer et al., 1999.12.10)

The mutant phenotype can be reverted by excision of the P{lacW}Trxr-1^G0481 insertion.

(Missirlis et al., 2001)

External Crossreferences and Linkouts ( 1 )

Crossreferences

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

AJ426769

Synonyms and Secondary IDs (9)

Reported As

Symbol Synonym

TrxR-1⁴⁸¹

(Staatz et al., 2005)

Trxr-1⁴⁸¹

(Frost et al., 2014, Missirlis et al., 2002)

Trxr-1^G0481

(Green et al., 2016)

Trxr1^G0481

dmtrxr-1⁴⁸¹

(Missirlis et al., 2001)

l(1)G0481

(Missirlis et al., 2002, Peter et al., 2002)

l(1)G0481^G0481

(Schäfer et al., 1999.12.10)

trxr-1⁴⁸¹

(Kuronen et al., 2009)

Name Synonyms

Thioredoxin reductase-1

(Kuronen et al., 2009)

Secondary FlyBase IDs

References (8)

Report Sections

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