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General Information
Symbol
Dmel\Trxr-1G0481
Species
D. melanogaster
Name
FlyBase ID
FBal0102623
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
Trxr-1481
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

P{lacW} insertion in exon 2, which contains the 5' untranslated region of the Trxr-1 mitochondrial transcript.

Insertion components
P{lacW}Trxr-1G0481
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Trxr-1G0481 homozygotes are lethal, pupae are elongated and third instar larvae present no obvious muscle phenotype, as compared to controls.

Homozygotes survive to the third larval instar, with 75% developing into pupae with 1 day of delay. About 20% eclose as normal looking adults, most of which die within 2-3 days of eclosion.

About 75% of hemizygotes dies as normal looking pharate adults or during eclosion. The life span of those flies that do eclose is severely reduced.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference
Suppressed by
Phenotype Manifest In
Enhancer of
Statement
Reference

Trxr-1G0481/Trxr-1[+] is an enhancer of eye phenotype of cathD1

Additional Comments
Genetic Interactions
Statement
Reference

A Trxr-1G0481 mutant background enhances by more than 10-fold the level of vacuolar change in cathD1 mutant retina.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
Comments
Comments

P{lacW} not verified as causing the lethality.

The mutant phenotype can be reverted by excision of the P{lacW}Trxr-1G0481 insertion.

External Crossreferences and Linkouts ( 1 )
Crossreferences
GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
Synonyms and Secondary IDs (8)
Reported As
Name Synonyms
Thioredoxin reductase-1
Secondary FlyBase IDs
    References (8)