Allele Dmel\klar^{glrs.T:Hsap\MYC}

General Information
Symbol	Dmel\klar^{glrs.T:Hsap\MYC}	Species	D. melanogaster
Name		FlyBase ID	FBal0102657
Feature type	allele	Associated gene	Dmel\klar

Allele class
Mutagen	in vitro construct - coding region fusion, in vitro construct - regulatory fusion
Recent Updates
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - coding region fusion (Mosley-Bishop et al., 1999) in vitro construct - regulatory fusion (Mosley-Bishop et al., 1999)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Construct: 150bp XbaI fragment containing the TATA box and transcription start of Hsp27 and a 200bp XbaI fragment containing five short gl-binding sites are fused to an klar cDNA tagged with T:Hsap\MYC. (Mosley-Bishop et al., 1999)
Carried in construct	P{glrs-klar.Myc} (Patterson et al., 2004, Mosley-Bishop et al., 1999)
Tagged with	T:Hsap\MYC (Mosley-Bishop et al., 1999, Patterson et al., 2004)
Cytology
Phenotypic Data
Phenotypic Class

Phenotype Manifest In
	eye (Mosley-Bishop et al., 1999) eye photoreceptor cell (Mosley-Bishop et al., 1999) ommatidium (Mosley-Bishop et al., 1999)
Detailed Description
	Statement Reference Some of the P{glrs-klar.Myc} lines exhibit an eye phenotype when present in two copies A rough eye phenotype is seen. In the retina, facets are disorganised and far too few photoreceptors are seen. (Mosley-Bishop et al., 1999)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhanced by
Statement Reference klar^{glrs.T:Hsap\MYC} has eye phenotype, enhanceable by Lam⁸³ (Patterson et al., 2004) klar^{glrs.T:Hsap\MYC} has eye phenotype, enhanceable by Lam^A25 (Patterson et al., 2004) klar^{glrs.T:Hsap\MYC} has eye phenotype, enhanceable by Lam^Ari3 (Patterson et al., 2004) klar^{glrs.T:Hsap\MYC} has eye phenotype, enhanceable by Lam^Ari7 (Patterson et al., 2004) klar^{glrs.T:Hsap\MYC} has eye phenotype, enhanceable by Lam^K2 (Patterson et al., 2004)
Additional Comments
Genetic Interactions
Statement Reference The following alleles enhance the rough eye phenotype of klar^{glrs.T:Hsap\MYC} mutants: Lam^Ari7, Lam^Ari3, Lam^A25, Lam^K2 and Lam⁸³. (Patterson et al., 2004)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Partially rescues	klar^{glrs.T:Hsap\MYC} partially rescues klar^marb-CD4 (Mosley-Bishop et al., 1999)
Comments	One copy of klar^{glrs.T:Hsap\MYC} almost completely rescues the homozygous klar^marb-CD4 eye phenotype. The ommatidia are nearly wildtype and the R-cell nuclei are apical. R-cell apical nuclear migration and cone cell migration are wild-type. (Mosley-Bishop et al., 1999)
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	klar^{glrs.T:Hsap\MYC} kls^{glrs.T:Hsap\MYC}
Name Synonym
Secondary FlyBase IDs

References ( 2 )
Research paper	Patterson et al., 2004, Mol. Biol. Cell 15(2): 600--610 The functions of klarsicht and nuclear lamin in developmentally regulated nuclear migrations of photoreceptor cells in the Drosophila eye. [FBrf0167866] Mosley-Bishop et al., 1999, Curr. Biol. 9(21): 1211--1220 Molecular analysis of the klarsicht gene and its role in nuclear migration within differentiating cells of the Drosophila eye. [FBrf0111985]

Allele Dmel\klarglrs.T:Hsap\MYC

Allele Dmel\klar^{glrs.T:Hsap\MYC}