Allele Dmel\dos^YY.sev.hs

General Information
Symbol	Dmel\dos^YY.sev.hs	Species	D. melanogaster
Name		FlyBase ID	FBal0102747
Feature type	allele	Associated gene	Dmel\dos

Allele class
Mutagen	in vitro construct - regulatory fusion, in vitro construct - amino acid replacement, in vitro construct - deletion
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - amino acid replacement (Herbst et al., 1999) in vitro construct - deletion (Herbst et al., 1999) in vitro construct - regulatory fusion (Herbst et al., 1999)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Construct: There is a deletion of codons 211-507. All Tyrosines outside of the DOS PH domain except Y801 and Y854 are either removed by deletion or changed to phenylalanine. Expression of the mutated dos cDNA is driven by a hybrid sev enhancer/heat shock promoter. (Herbst et al., 1999)
Carried in construct	P{sE-dos^YY} (Herbst et al., 1999)
Cytology
Phenotypic Data
Phenotypic Class
	wild-type (Herbst et al., 1999)
Phenotype Manifest In

Detailed Description
	Statement Reference
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhancer of
Statement Reference dos^YY.sev.hs is an enhancer of eye phenotype of sev^{S11.T:Hsap\MYC} (Herbst et al., 1999) dos^YY.sev.hs is an enhancer of ommatidium phenotype of sev^{S11.T:Hsap\MYC} (Herbst et al., 1999)
Suppressor of
Statement Reference dos^YY.sev.hs is a suppressor of phenotype of csw^CS.hs.2sev (Herbst et al., 1999)
Additional Comments
Genetic Interactions
Statement Reference The addition of dos^YY.sev.hs enhances the rough eye phenotype seen in sev^{S11.T:Hsap\MYC} flies. (Herbst et al., 1999)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescues	dos^YY.sev.hs rescues dos^1.46/dos^2.42 (Herbst et al., 1999) dos^YY.sev.hs rescues dos^P115 (Herbst et al., 1999)
Partially rescues	dos^YY.sev.hs partially rescues dos^1.46/dos^2.42 (Herbst et al., 1999)
Comments	The addition of dos^YY.sev.hs strongly suppresses the rough eye phenotype seen in csw^CS.hs.2sev; dos^1.46 flies. In dos^1.46/dos^2.42 flies rescued by dos^YY.sev.hs, occasional ommatidia are observed that lack a R7 or R1-6 photoreceptor cell. Heat shock expression of dos^YY.sev.hs rescues the lethality and almost rescues the eye phenotype seen in dos^1.46/dos^2.42 or homozygous dos^P115 flies. (Herbst et al., 1999)
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	dos^YY.sev.hs
Name Synonym
Secondary FlyBase IDs

References ( 1 )
Research paper	Herbst et al., 1999, EMBO J. 18(24): 6950--6961 Recruitment of the protein tyrosine phosphatase CSW by DOS is an essential step during signaling by the sevenless receptor tyrosine kinase. [FBrf0123046]

Allele Dmel\dosYY.sev.hs

Allele Dmel\dos^YY.sev.hs