Allele Dmel\disp^{Scer\UAS.T:Ivir\HA1}

General Information
Symbol	Dmel\disp^{Scer\UAS.T:Ivir\HA1}	Species	D. melanogaster
Name		FlyBase ID	FBal0102760
Feature type	allele	Associated gene	Dmel\disp

Allele class
Mutagen	in vitro construct - regulatory fusion, in vitro construct - coding region fusion
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - coding region fusion (Burke et al., 1999) in vitro construct - regulatory fusion (Burke et al., 1999)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Construct: Scer\UAS regulatory sequences drive expression of disp tagged at the 3' end with a triple T:Ivir\HA1 tag. αTub84B 3' UTR sequences are fused downstream of the T:Ivir\HA1 sequences. (Burke et al., 1999)
Carried in construct	P{UAS-disp.HA1} (Burke et al., 1999, Gallet et al., 2006, Deshpande and Schedl, 2005, Casali, 2010, Callejo et al., 2011)
Tagged with	T:Ivir\HA1 (Burke et al., 1999, Gerlitz and Basler, 2002)
Cytology
Phenotypic Data
Phenotypic Class

Phenotype Manifest In

Detailed Description
	Statement Reference
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference Clones of peripodial cells expressing both hh^{N.Scer\UAS.cGa} and disp^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^unspecified induce significant outgrowth of the anterior compartment of the wing imaginal disc. (Gallet et al., 2006)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Partially rescues	Scer\GAL4^en-e16E/disp^{Scer\UAS.T:Ivir\HA1} partially rescues disp^S037707 (Burke et al., 1999)
Comments	Rescues disp^S037707 animals to adulthood when expressed under the control of Scer\GAL4^en-e16E. The rescued flies have normal patterning in the wing, leg, notum and abdomen and give rise to viable offspring, but have a dramatic reduction in eye size. (Burke et al., 1999)
Stocks ( 0 )

Notes on Origin
Discoverer

Comments
	Carried in a plasmid and transfected into S2 cells. (Gerlitz and Basler, 2002)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	disp^{Scer\UAS.T:Ivir\HA1}
Name Synonym
Secondary FlyBase IDs

References ( 6 )
Research paper	Callejo et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(31): 12591--12598 Feature Article: From the Cover: Dispatched mediates Hedgehog basolateral release to form the long-range morphogenetic gradient in the Drosophila wing disk epithelium. [FBrf0214615] Casali, 2010, Sci. Signal. 3(136): ra63 Self-induced patched receptor down-regulation modulates cell sensitivity to the hedgehog morphogen gradient. [FBrf0214124] Gallet et al., 2006, Development 133(3): 407--418 Cholesterol modification is necessary for controlled planar long-range activity of Hedgehog in Drosophila epithelia. [FBrf0190290] Deshpande and Schedl, 2005, Dev. Cell 9(5): 629--638 HMGCoA reductase potentiates hedgehog signaling in Drosophila melanogaster. [FBrf0190201] Gerlitz and Basler, 2002, Genes Dev. 16(9): 1055--1059 Wingful, an extracellular feedback inhibitor of Wingless. [FBrf0147039] Burke et al., 1999, Cell 99(7): 803--815 Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signaling cells. [FBrf0122981]

Allele Dmel\dispScer\UAS.T:Ivir\HA1

Allele Dmel\disp^{Scer\UAS.T:Ivir\HA1}