Allele Dmel\InR^Scer\UAS.cHa

General Information
Symbol	Dmel\InR^Scer\UAS.cHa	Species	D. melanogaster
Name	Saccharomyces cerevisiae UAS construct a of Huang	FlyBase ID	FBal0102968
Feature type	allele	Associated gene	Dmel\InR

Allele class
Mutagen	in vitro construct - regulatory fusion
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen	in vitro construct - regulatory fusion (Huang et al., 1999)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Construct: Expression of InR is governed by Scer\UAS regulatory sequences. (Huang et al., 1999)
Carried in construct	P{UAS-InR.H} (Wang et al., 2005, Mirth et al., 2005, Medioni and Noselli, 2005, Raisin et al., 2003, Rintelen et al., 2001, Britton et al., 2002, Morey et al., 2001, Hsu et al., 2007, Prober and Edgar, 2002, Wittwer et al., 2005, Brogiolo et al., 2001, Huang et al., 1999, Wessells et al., 2004, Sustar and Schubiger, 2005, Scott et al., 2004, Potter et al., 2001, Yang and Baker, 2003, Mann et al., 2012, Zheng et al., 2007, Mirth et al., 2009, Honegger et al., 2008, Xu et al., 2008)
Cytology
Phenotypic Data
Phenotypic Class
	aging defective, with Scer\GAL4^Scer\UAS.cHa, Scer\GAL4^tin.cBa (Wessells et al., 2004) circadian rhythm defective, with Scer\GAL4^Switch1.106 (Zheng et al., 2007) circadian rhythm defective, with Scer\GAL4^tim.Scer\UAS (Zheng et al., 2007) feeding behavior defective, with Scer\GAL4^Adh.PF (Britton et al., 2002) hyperplasia, with Scer\GAL4^GMR.PF (Wittwer et al., 2005) increased cell size, with Scer\GAL4^ey.PH (Brogiolo et al., 2001) increased cell size \| somatic clone, with Scer\GAL4^Act5C.PP (Prober and Edgar, 2002, Britton et al., 2002, Wang et al., 2005) lethal, with Scer\GAL4^Act5C.PP (Britton et al., 2002) lethal, with Scer\GAL4^Adh.PF (Britton et al., 2002) lethal, with Scer\GAL4^ey.PH (Huang et al., 1999) lethal, with Scer\GAL4^Lk6-DJ634 (Zheng et al., 2007) lethal \| embryonic stage, with Scer\GAL4^en-e16E (Wittwer et al., 2005) lethal \| heat sensitive, with Scer\GAL4^ey.PH (Potter et al., 2001) oxidative stress response defective, with Scer\GAL4^Switch1.106 (Zheng et al., 2007) oxidative stress response defective, with Scer\GAL4^tim.Scer\UAS (Zheng et al., 2007) small body \| pharate adult stage, with Scer\GAL4^phm.PO (Mirth et al., 2005) viable, with Scer\GAL4^Scer\UAS.cHa, Scer\GAL4^tin.cBa (Wessells et al., 2004) visible, with Scer\GAL4^dpp.blk1 (Sustar and Schubiger, 2005) visible, with Scer\GAL4^ey.PH (Potter et al., 2001, Brogiolo et al., 2001) visible, with Scer\GAL4^GMR.PB (Brogiolo et al., 2001) visible, with Scer\GAL4^GMR.PF (Rintelen et al., 2001, Honegger et al., 2008) visible, with Scer\GAL4^ptc-559.1 (Hsu et al., 2007)
Phenotype Manifest In
	1st posterior cell, with Scer\GAL4^ptc-559.1 (Hsu et al., 2007) adult heart, with Scer\GAL4^Scer\UAS.cHa, Scer\GAL4^tin.cBa (Wessells et al., 2004) arista, with Scer\GAL4^dpp.blk1 (Sustar and Schubiger, 2005) capitellum, with Scer\GAL4^dpp.blk1 (Sustar and Schubiger, 2005) chaeta \| ectopic, with Scer\GAL4^dpp.blk1 (Sustar and Schubiger, 2005) coxa \| proximal, with Scer\GAL4^dpp.blk1 (Sustar and Schubiger, 2005) embryonic/larval digestive system \| somatic clone, with Scer\GAL4^Act5C.PP (Britton et al., 2002) embryonic/larval epidermis \| somatic clone, with Scer\GAL4^Act5C.PP (Britton et al., 2002) embryonic/larval fat body \| somatic clone, with Scer\GAL4^Act5C.PP (Britton et al., 2002, Wang et al., 2005) embryonic/larval Malpighian tubule \| somatic clone, with Scer\GAL4^Act5C.PP (Britton et al., 2002) eye, with Scer\GAL4^ey.PH (Brogiolo et al., 2001, Huang et al., 1999) eye, with Scer\GAL4^GMR.PB (Brogiolo et al., 2001) eye, with Scer\GAL4^GMR.PF (Rintelen et al., 2001, Morey et al., 2001, Wittwer et al., 2005, Honegger et al., 2008) gonopod thorn bristle \| ectopic, with Scer\GAL4^dpp.blk1 (Sustar and Schubiger, 2005) haltere pedicel, with Scer\GAL4^dpp.blk1 (Sustar and Schubiger, 2005) mitotic cell cycle \| somatic clone, with Scer\GAL4^Act5C.PP (Prober and Edgar, 2002) ommatidium, with Scer\GAL4^ey.PH (Potter et al., 2001, Brogiolo et al., 2001) ommatidium, with Scer\GAL4^GMR.PF (Xu et al., 2008) photoreceptor cell, with Scer\GAL4^ey.PH (Brogiolo et al., 2001) photoreceptor cell \| ectopic \| larval stage, with Scer\GAL4^GMR.PF (Yang and Baker, 2003) photoreceptor cell \| P-stage \| ectopic, with Scer\GAL4^GMR.PF (Yang and Baker, 2003) sensillum trichodeum \| supernumerary, with Scer\GAL4^dpp.blk1 (Sustar and Schubiger, 2005) third segment of antenna, with Scer\GAL4^dpp.blk1 (Sustar and Schubiger, 2005)
Detailed Description
	Statement Reference Expression of InR[Scer\UAS.cHa] under the control of Scer\GAL4[GMR.PF] does not produce R8 photoreceptor cell phenotypes. (Mann et al., 2012) Overexpression of InR[Scer\UAS.cHa] under the control of Scer\GAL4[GMR.PF] results in eye hyperplasia. (Honegger et al., 2008) Expression of InR[Scer\UAS.cHa] under the control of Scer\GAL4[GMR.PF] leads to an increase in ommatidia size. (Xu et al., 2008) Expression of InR^Scer\UAS.cHa under the control of Scer\GAL4^ptc-559.1 results in a weak but consistent expansion of the distance between wing veins L3 and L4. (Hsu et al., 2007) Expression of InR[Scer\UAS.cHa] under the control of Scer\GAL4[tim.Scer\UAS], dramatically increases sensitivity to oxidative stress. These flies die within 2 days of being challenged with 1mM paraquat. When treated with 0.05-0.1mM paraquat they survive up to 6 days, with the majority showing arrhythmic locomotor behavior. Expression of Akt1[Scer\UAS.T:Ivir\HA1,T:Uuuu\MyrPalm1] under the control of Scer\GAL4[Switch1.106], increases sensitivity of behavioral rhythms to paraquat. (Zheng et al., 2007) Expression of InR^Scer\UAS.cHa in border cells, driven by Scer\GAL4^slbo.2.6 does not affect the formation of the egg chamber apical cap or the migration of the border cell cluster to the oocyte. (Medioni and Noselli, 2005) Pharate adults expressing InR^Scer\UAS.cHa under the control of Scer\GAL4^phm.PO are 42% of the weight of controls when larvae have been raised in constant light. (Mirth et al., 2005) Expression of InR^Scer\UAS.cHa under the control of Scer\GAL4^dpp.blk1 results in ectopic bristles and an excess of sensilla trichodea in the most proximal part of the coxa, ectopic bristles in the arista and third antennal segment, ectopic bristles in the capitellum and occasionally in the pedicellum of the haltere and ectopic thorn bristles in the female genitalia. (Sustar and Schubiger, 2005) Cells in InR^Scer\UAS.cHa; Scer\GAL4^Act5C.PP somatic clonesi n the larval fat body overgrow dramatically. (Wang et al., 2005) The eyes of InR^Scer\UAS.cHa; Scer\GAL4^GMR.PF flies have massive overgrowth. (Wittwer et al., 2005) Flies that express InR^Scer\UAS.cHa under the control of both Scer\GAL4^tin.cBa and Scer\GAL4^Scer\UAS.cHa show a consistently low heart rate across all ages compared to wild-type flies. These flies show an increased rate of stress-induced heart failure at the age of one week compared to in wild type. The rate of this heart failure does increase with age, but at a markedly reduced magnitude compared to wild type. These effects are true for both male and female. (Wessells et al., 2004) Almost all endogenous caspase activation is blocked in InR^Scer\UAS.cHa; Scer\GAL4^GMR.PF eye discs of third instar larvae and 30 hours APF pupae. This is accompanied by an increase in photoreceptor differentiation at both of these stages. (Yang and Baker, 2003) Clones of cells expressing InR^Scer\UAS.cHa under the control of Scer\GAL4^Act5C.PP in the gut, fat body, Malpighian tubules and epidermis are only slightly larger than control cells at the time of larval hatching. After several days of starvation on 20% sucrose, these cells are much larger than adjacent control cells and have a visibly increased DNA content. Gut and fat body cells expressing InR^Scer\UAS.cHa under the control of Scer\GAL4^Act5C.PP continue to replicate their DNA for at least 2-3 days under starvation conditions. Expression of InR^Scer\UAS.cHa in third larval instar fat body cells under the control of Scer\GAL4^Act5C.PP increases the opacity of the cytoplasm, thus promoting nutrient storage. The cytoplasm of the cells contains many more, but much smaller, lipid droplets than neighbouring control cells. Some fed animals expressing InR^Scer\UAS.cHa under the control of Scer\GAL4^Adh.PF survive to the third larval instar and a few viable adults eclose. In contrast, expression of InR^Scer\UAS.cHa under the control of Scer\GAL4^Adh.PF in starved animals results in first instar larvae dying within 3-4 days of hatching (control animals survive 8-9 days). Animals expressing InR^Scer\UAS.cHa under the control of Scer\GAL4^Adh.PF feed poorly, often having no food in their gut, and frequently wander away from their food. (Britton et al., 2002) Expression of InR^Scer\UAS.cHa under the control of Scer\GAL4^Act5C.PP in clones results in an increase in cell size and an increase in clone area compared to controls. (Prober and Edgar, 2002) InR^Scer\UAS.cHa when driven by Scer\GAL4^ey.PH causes hyperproliferative outgrowth and an increase in cell size in the eye. A relatively normal ommatidial arrangement and architecture are retained. (Brogiolo et al., 2001) When InR^Scer\UAS.cHa is driven by Scer\GAL4^GMR.PF the flies have enlarged eyes due to an increase in cell number and cell size. (Morey et al., 2001) Expression of InR^Scer\UAS.cHa under the control of Scer\GAL4^ey.PH results in lethality at 25^oC and a dramatic increase in ommatidia number in escapers at room temperature. (Potter et al., 2001) When expression is driven by Scer\GAL4^ey.PH at 25^oC lethality results. At room temperature, a few flies survive with over proliferated eyes. (Huang et al., 1999)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement Reference InR^Scer\UAS.cHa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, enhanceable by Pdk1^4ΔEP/Pdk1^EP3091, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Rintelen et al., 2001)
Suppressed by
Statement Reference InR^Scer\UAS.cHa, Scer\GAL4^Act5C.PP has increased cell size \| somatic clone phenotype, suppressible \| partially by hep^Act.Scer\UAS, Scer\GAL4^Act5C.PP (Wang et al., 2005) InR^Scer\UAS.cHa, Scer\GAL4^en-e16E has lethal \| embryonic stage phenotype, suppressible by B4^Scer\UAS.cSa (Wittwer et al., 2005) InR^Scer\UAS.cHa, Scer\GAL4^ey.PH has lethal \| heat sensitive phenotype, suppressible by gig^Scer\UAS.cTa/gig^Scer\UAS.cTa/Tsc1^Scer\UAS.cPa, Scer\GAL4^ey.PH (Potter et al., 2001) InR^Scer\UAS.cHa, Scer\GAL4^ey.PH has visible phenotype, suppressible by gig^Scer\UAS.cTa/gig^Scer\UAS.cTa/Tsc1^Scer\UAS.cPa, Scer\GAL4^ey.PH (Potter et al., 2001) InR^Scer\UAS.cHa, Scer\GAL4^GMR.PB has visible phenotype, suppressible by Df(3L)AC1 (Brogiolo et al., 2001) InR^Scer\UAS.cHa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has hyperplasia phenotype, suppressible by B4^EP7-66 (Wittwer et al., 2005) InR^Scer\UAS.cHa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has hyperplasia phenotype, suppressible by B4^Scer\UAS.cSa (Wittwer et al., 2005) InR^Scer\UAS.cHa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, suppressible \| partially by ImpL2^Scer\UAS.cHa, Scer\GAL4^GMR.PF (Honegger et al., 2008) InR^Scer\UAS.cHa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, suppressible by ImpL2^EP5.66, Scer\GAL4^GMR.PF (Honegger et al., 2008) InR^Scer\UAS.cHa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, suppressible by ImpL2^s.Scer\UAS, Scer\GAL4^GMR.PF (Honegger et al., 2008) InR^Scer\UAS.cHa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, suppressible by Pdk1^4ΔEP/Pdk1^EP3091, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Rintelen et al., 2001) InR^Scer\UAS.cHa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, suppressible by Pk61C[+]/Pdk1^5ΔEP, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Rintelen et al., 2001)
NOT suppressed by
Statement Reference InR^Scer\UAS.cHa, Scer\GAL4^ey.PH has lethal \| heat sensitive phenotype, non-suppressible by gig^Scer\UAS.cTa/gig^Scer\UAS.cTa, Scer\GAL4^ey.PH (Potter et al., 2001) InR^Scer\UAS.cHa, Scer\GAL4^ey.PH has lethal \| heat sensitive phenotype, non-suppressible by Tsc1^Scer\UAS.cPa, Scer\GAL4^ey.PH (Potter et al., 2001) InR^Scer\UAS.cHa, Scer\GAL4^ey.PH has visible phenotype, non-suppressible by gig^Scer\UAS.cTa/gig^Scer\UAS.cTa, Scer\GAL4^ey.PH (Potter et al., 2001) InR^Scer\UAS.cHa, Scer\GAL4^ey.PH has visible phenotype, non-suppressible by Tsc1^Scer\UAS.cPa, Scer\GAL4^ey.PH (Potter et al., 2001) InR^Scer\UAS.cHa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by ImpL2^MG2, Scer\GAL4^GMR.PF (Honegger et al., 2008)
Enhancer of
Statement Reference InR^Scer\UAS.cHa, Scer\GAL4^GMR.PF is an enhancer of neuroanatomy defective phenotype of Scer\GAL4^GMR.PF, gogo^DDD.Scer\UAS (Mann et al., 2012) InR^Scer\UAS.cHa, Scer\GAL4^GMR.PF is an enhancer of neuroanatomy defective phenotype of Scer\GAL4^GMR.PF, gogo^Scer\UAS.T1 (Mann et al., 2012)
Phenotype Manifest In
Enhanced by
Statement Reference InR^Scer\UAS.cHa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, enhanceable by Pdk1^4ΔEP/Pdk1^EP3091, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Rintelen et al., 2001)
Suppressed by
Statement Reference InR^Scer\UAS.cHa, Scer\GAL4^Act5C.PP has embryonic/larval fat body \| somatic clone phenotype, suppressible \| partially by hep^Act.Scer\UAS, Scer\GAL4^Act5C.PP (Wang et al., 2005) InR^Scer\UAS.cHa, Scer\GAL4^ey.PH has eye phenotype, suppressible by Pten^Scer\UAS.cHa, Scer\GAL4^ey.PH (Huang et al., 1999) InR^Scer\UAS.cHa, Scer\GAL4^ey.PH has ommatidium phenotype, suppressible by gig^Scer\UAS.cTa/gig^Scer\UAS.cTa/Tsc1^Scer\UAS.cPa, Scer\GAL4^ey.PH (Potter et al., 2001) InR^Scer\UAS.cHa, Scer\GAL4^GMR.PB has eye phenotype, suppressible by Df(3L)AC1 (Brogiolo et al., 2001) InR^Scer\UAS.cHa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, suppressible \| partially by ImpL2^Scer\UAS.cHa, Scer\GAL4^GMR.PF (Honegger et al., 2008) InR^Scer\UAS.cHa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, suppressible by B4^EP7-66 (Wittwer et al., 2005) InR^Scer\UAS.cHa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, suppressible by ImpL2^EP5.66, Scer\GAL4^GMR.PF (Honegger et al., 2008) InR^Scer\UAS.cHa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, suppressible by ImpL2^s.Scer\UAS, Scer\GAL4^GMR.PF (Honegger et al., 2008) InR^Scer\UAS.cHa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, suppressible by Pdk1^4ΔEP/Pdk1^EP3091, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Rintelen et al., 2001) InR^Scer\UAS.cHa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, suppressible by Pk61C[+]/Pdk1^5ΔEP, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Rintelen et al., 2001) InR^Scer\UAS.cHa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has ommatidium phenotype, suppressible \| partially by Hsap\RPL8^DN.Scer\UAS, Scer\GAL4^GMR.PF (Xu et al., 2008) InR^Scer\UAS.cHa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has ommatidium phenotype, suppressible \| partially by RpL8^{dsRNA.Scer\UAS}, Scer\GAL4^GMR.PF (Xu et al., 2008)
NOT suppressed by
Statement Reference InR^Scer\UAS.cHa, Scer\GAL4^ey.PH has ommatidium phenotype, non-suppressible by gig^Scer\UAS.cTa/gig^Scer\UAS.cTa, Scer\GAL4^ey.PH (Potter et al., 2001) InR^Scer\UAS.cHa, Scer\GAL4^ey.PH has ommatidium phenotype, non-suppressible by Tsc1^Scer\UAS.cPa, Scer\GAL4^ey.PH (Potter et al., 2001) InR^Scer\UAS.cHa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by ImpL2^MG2, Scer\GAL4^GMR.PF (Honegger et al., 2008) InR^Scer\UAS.cHa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by SelD^k11320 (Morey et al., 2001)
Enhancer of
Statement Reference InR^Scer\UAS.cHa, Scer\GAL4^GMR.PF is an enhancer of medulla layer M1 phenotype of Scer\GAL4^GMR.PF, gogo^DDD.Scer\UAS (Mann et al., 2012) InR^Scer\UAS.cHa, Scer\GAL4^GMR.PF is an enhancer of medulla layer M1 phenotype of Scer\GAL4^GMR.PF, gogo^Scer\UAS.T1 (Mann et al., 2012) InR^Scer\UAS.cHa, Scer\GAL4^GMR.PF is an enhancer of photoreceptor cell R8 phenotype of Scer\GAL4^GMR.PF, gogo^DDD.Scer\UAS (Mann et al., 2012) InR^Scer\UAS.cHa, Scer\GAL4^GMR.PF is an enhancer of photoreceptor cell R8 phenotype of Scer\GAL4^GMR.PF, gogo^Scer\UAS.T1 (Mann et al., 2012)
Additional Comments
Genetic Interactions
Statement Reference Expression of InR[Scer\UAS.cHa] strongly enhances the R8 photoreceptor phenotype seen when gogo[Scer\UAS.T1] is expressed under the control of Scer\GAL4[GMR.PF], resulting in an increase in the size of the blob-like structures seen in the medulla M1 layer. Premature axon stopping is also visible. No R8 photoreceptor phenotypes are seen when gogo[FFD.Scer\UAS] and InR[Scer\UAS.cHa] are co-expressed under the control of Scer\GAL4[GMR.PF]. Expression of InR[Scer\UAS.cHa] slightly enhances the R8 axon stopping phenotype seen when gogo[DDD.Scer\UAS] is expressed under the control of Scer\GAL4[GMR.PF]. (Mann et al., 2012) ImpL2[EP5.66] suppresses the big eye phenotype resulting from the overexpression of InR[Scer\UAS.cHa] driven by Scer\GAL4[GMR.PF]. ImpL2[MG2] fails to suppresses the big eye phenotype resulting from the overexpression of InR[Scer\UAS.cHa] driven by Scer\GAL4[GMR.PF]. ImpL2[Scer\UAS.cHa] partially suppresses the eye overgrowth resulting from the overexpression of InR[Scer\UAS.cHa] driven by Scer\GAL4[GMR.PF]. ImpL2[s.Scer\UAS] completely reverses the eye overgrowth resulting from the overexpression of InR[Scer\UAS.cHa] driven by Scer\GAL4[GMR.PF]. (Honegger et al., 2008) Expression of RpL8[dsRNA.Scer\UAS] partially suppresses the increase in ommatidia size seen when InR[Scer\UAS.cHa] is expressed under the control of Scer\GAL4[GMR.PF]. (Xu et al., 2008) The distance between wing veins L3 and L4 is smaller than normal in flies co-expressing InR^Scer\UAS.cHa and Tctp^{dsRNA.Scer\UAS} under the control of Scer\GAL4^ptc-559.1, resembling the phenotype seen in flies expressing Tctp^{dsRNA.Scer\UAS} alone under the control of Scer\GAL4^ptc-559.1. (Hsu et al., 2007) Overgrowth of cells in InR^Scer\UAS.cHa; Scer\GAL4^Act5C.PP clones in the larval fat body is largely suppressed by hep^Act.Scer\UAS. (Wang et al., 2005) The massive overgrowth of eyes seen in InR^Scer\UAS.cHa; Scer\GAL4^GMR.PF flies is suppressed by B4^EP7-66 or B4^Scer\UAS.cSa. Embryonic lethality due to InR^Scer\UAS.cHa; Scer\GAL4^en-e16E is also suppressed by B4^Scer\UAS.cSa. (Wittwer et al., 2005) The addition of Df(3L)AC1 to InR^Scer\UAS.cHa, Scer\GAL4^GMR.PB flies, suppresses the eye phenotype seen in these flies. The subsequent addition of Ilp2^Scer\UAS.cBa reverts the suppression. (Brogiolo et al., 2001) Coexpression of both gig^Scer\UAS.cTa and Tsc1^Scer\UAS.cPa (but not either gig^Scer\UAS.cTa or Tsc1^Scer\UAS.cPa alone) rescues the lethality and extra ommatidia phenotype of flies expressing InR^Scer\UAS.cHa under the control of Scer\GAL4^ey.PH. (Potter et al., 2001) Eye size in animals expressing InR^Scer\UAS.cHa under the control of Scer\GAL4^GMR.PF is restored almost to wild type by Pk61C^EP3091/Pk61C^4ΔEP, although eye roughness is increased. (Rintelen et al., 2001)
Xenogenetic Interactions
Statement Reference Expression of Hsap\RPL8[DN.Scer\UAS] partially suppresses the increase in ommatidia size seen when InR[Scer\UAS.cHa] is expressed under the control of Scer\GAL4[GMR.PF]. (Xu et al., 2008)
Complementation & Rescue Data
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Notes on Origin
Discoverer

External Crossreferences & Linkouts
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Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	InR^Scer\UAS.cHa
Name Synonym	Saccharomyces cerevisiae UAS construct a of Huang (Huang et al., 1999)
Secondary FlyBase IDs

References ( 23 )

Generate a list of	All references relating to this allele ( 23 )

List References by type	Research paper ( 22 ) Supplementary material ( 1 )
Recent research papers ( 1 )
	Mann et al., 2012, Development 139(4): 760--771 A putative tyrosine phosphorylation site of the cell surface receptor Golden goal is involved in synaptic layer selection in the visual system. [FBrf0217291] Show all research papers ...

Allele Dmel\InRScer\UAS.cHa

Allele Dmel\InR^Scer\UAS.cHa