FB2025_01 , released February 20, 2025
Allele: Dmel\DCTN1-p150Δ.UAS
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General Information
Symbol
Dmel\DCTN1-p150Δ.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0102986
Feature type
allele
Associated gene
Dmel\DCTN1-p150
Associated Insertion(s)
Carried in Construct
P{UAS-DCTN1-p150Δ}
Also Known As
UAS-GluedDN, UAS-DNGlued, UAS:GluedDN, UAS-Glued-DN, UAS-D82glued
Key Links
Transgenic product class
inframe_deletion
(Allen et al., 1999)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Allen et al., 1999)
Mutagen
in vitro construct
(Allen et al., 1999)
Progenitor genotype
Carried in construct
P{UAS-DCTN1-p150Δ}
Cytology
Description

Expression of a 2897bp truncated Gl cDNA, carrying only the N-terminal 922 amino acids, is governed by UASt regulatory sequences.

(Allen et al., 1999)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
DCTN1-p150
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  motor neuron disease
      CEA
      (Rawson et al., 2012)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class

      abnormal neuroanatomy, with Scer\GAL4c17

      (Allen et al., 1999)

      abnormal neuroanatomy, with Scer\GAL4elav-C155

      (Pielage et al., 2005, Eaton et al., 2002)

      abnormal neuroanatomy, with Scer\GAL4RapGAP1-OK6

      (Liu et al., 2010)

      abnormal neuroanatomy, with Scer\GAL4shot-OK307

      (Allen et al., 1999)

      abnormal neuroanatomy, with Scer\GAL4αTub84B.PP

      (Roy et al., 2007)

      abnormal neuroanatomy | adult stage, with Scer\GAL4shot-OK307

      (Kudumala et al., 2017, Ma et al., 2009)

      abnormal neuroanatomy | conditional, with Scer\GAL4unspecified

      (Xiong et al., 2010)

      abnormal neuroanatomy | progressive, with Scer\GAL4E49

      (Rawson et al., 2012)

      abnormal neuroanatomy | third instar larval stage, with Scer\GAL4Toll-6-D42

      (Chang et al., 2013)

      abnormal neurophysiology, with Scer\GAL4c17

      (Allen et al., 1999)

      abnormal neurophysiology, with Scer\GAL4E49

      (Rawson et al., 2012)

      abnormal neurophysiology, with Scer\GAL4elav-C155

      (Eaton et al., 2002)

      abnormal neurophysiology, with Scer\GAL4shot-OK307

      (Allen et al., 1999)

      abnormal neurophysiology | adult stage, with Scer\GAL4shot-OK307

      (Ma et al., 2009)

      abnormal proboscis extension reflex | progressive, with Scer\GAL4E49

      (Rawson et al., 2012)

      abnormal size | adult stage, with Scer\GAL4shot-OK307

      (Kudumala et al., 2017)

      lethal - all die before end of larval stage, with Scer\GAL4c311

      (Gibson and Schubiger, 2000)

      lethal - all die before end of larval stage, with Scer\GAL4elav-C155

      (Lloyd et al., 2012)

      partially lethal, with Scer\GAL4dimm-929

      (Marques et al., 2003)

      short lived, with Scer\GAL4RapGAP1-OK6

      (Rawson et al., 2012)

      short lived, with Scer\GAL4Toll-6-D42

      (Rawson et al., 2012)

      some die during larval stage, with Scer\GAL4c311

      (Gibson and Schubiger, 2000)

      some die during larval stage, with Scer\GAL4elav-C155

      (Lloyd et al., 2012)

      uncoordinated, with Scer\GAL4dimm-929

      (Marques et al., 2003)

      visible, with Scer\GAL4CCAP.PP

      (Bohm et al., 2010)

      visible, with Scer\GAL4GMR.PF

      (Ma et al., 2009, Allen et al., 1999)

      visible, with Scer\GAL4hs.2sev

      (Allen et al., 1999)
      Phenotype Manifest In

      adult CSD interneuron, with Scer\GAL4αTub84B.PP

      (Roy et al., 2007)

      adult neuromuscular junction, with Scer\GAL4E49

      (Rawson et al., 2012)

      bouton, with Scer\GAL4elav-C155

      (Eaton et al., 2002)

      centrosome, with Scer\GAL4neur-P72

      (Jauffred et al., 2013)

      embryonic/larval dorsal tracheal branch | embryonic stage, with Scer\GAL4btl.PU

      (Caviglia et al., 2016)

      external sensory organ precursor cell I, with Scer\GAL4neur-P72

      (Jauffred et al., 2013)

      eye, with Scer\GAL4GMR.PF

      (Ma et al., 2009, Allen et al., 1999)

      eye, with Scer\GAL4hs.2sev

      (Allen et al., 1999)

      eye disc, with Scer\GAL4c311

      (Gibson and Schubiger, 2000)

      eye disc morphogenetic furrow, with Scer\GAL4c311

      (Gibson and Schubiger, 2000)

      eye photoreceptor cell & nucleus, with Scer\GAL4Glass38-1

      (Whited et al., 2004)

      giant fiber neuron, with Scer\GAL4c17

      (Allen et al., 1999)

      giant fiber neuron, with Scer\GAL4shot-OK307

      (Ma et al., 2009, Allen et al., 1999)

      giant fiber neuron | adult stage, with Scer\GAL4GMR68A06

      (Kudumala et al., 2017)

      giant fiber neuron | adult stage, with Scer\GAL4shot-OK307

      (Kudumala et al., 2017)

      giant fibers & nerve terminal, with Scer\GAL4c17

      (Allen et al., 1999)

      giant fibers & nerve terminal, with Scer\GAL4shot-OK307

      (Allen et al., 1999)

      giant fibers & synapse, with Scer\GAL4c17

      (Allen et al., 1999)

      giant fibers & synapse, with Scer\GAL4shot-OK307

      (Allen et al., 1999)

      interommatidial bristle, with Scer\GAL4GMR.PF

      (Ma et al., 2009)

      larval Bolwig's organ & nucleus, with Scer\GAL4elav.PLu

      (Whited et al., 2004)

      larval neuron, with Scer\GAL4ap-md544

      (Allan et al., 2003)

      larval segmental nerve | conditional, with Scer\GAL4unspecified

      (Xiong et al., 2010)

      ommatidium, with Scer\GAL4GMR.PF

      (Ma et al., 2009)

      photoreceptor cell R7 | somatic clone, with Scer\GAL4Act5C.PP

      (Ting et al., 2007)

      postsynaptic membrane, with Scer\GAL4elav-C155

      (McCabe et al., 2003, Eaton et al., 2002)

      proboscis muscle cell, with Scer\GAL4E49

      (Rawson et al., 2012)

      synapse, with Scer\GAL4elav-C155

      (Pielage et al., 2005, Eaton et al., 2002)

      synapse, with Scer\GAL4RapGAP1-OK6

      (Liu et al., 2010)

      synapse & neuromuscular junction, with Scer\GAL4elav-C155

      (McCabe et al., 2003)

      transport vesicle | adult stage, with Scer\GAL4GMR68A06

      (Kudumala et al., 2017)

      type Ib terminal bouton | third instar larval stage, with Scer\GAL4Toll-6-D42

      (Chang et al., 2013)

      wing, with Scer\GAL4CCAP.PP

      (Bohm et al., 2010)

      wing, with Scer\GAL4dimm-929

      (Marques et al., 2003)
      Detailed Description
      Statement
      Reference

      The expression of DCTN1-p150Δ.Scer\UAS under the control of Scer\GAL4shot-OK307 results in shorter and thinner giant fiber terminals, as compared to controls. Expression under the control of Scer\GAL4GMR68A06 leads to a severe impairment of the axonal transport of Nrg-positive vesicles in giant fibers, as compared to controls.

      (Kudumala et al., 2017)

      Expression of DCTN1-p150Δ.Scer\UAS under the control of Scer\GAL4btl.PU in embryos leads to defects in dorsal branch tube fusion.

      (Caviglia et al., 2016)

      Expression of GlΔ.Scer\UAS under the control of Scer\GAL4D42 results in a reduced number of type 1b boutons at the neuromuscular junction in third-instar larvae.

      Third instar larvae expressing GlΔ.Scer\UAS under the control of Scer\GAL4D42 have axonal blockages.

      (Chang et al., 2013)

      Centrosome dynamics during cell division in pI (sensory organ precursor) cells in the notum expressing GlΔ.Scer\UAS under the control of Scer\GAL4neur-P72 proceed normally from prophase to anaphase. However, in telophase both centrosomes fail to move towards the apex of the pI daughter cells.

      (Jauffred et al., 2013)

      Survival data from virgin females expressing GlΔ.Scer\UAS under the control of Scer\GAL4RapGAP1-OK6 generated on standard laboratory food demonstrate that Gl1 mutants have significant reduction in survival including changes in median and maximum lifespan compared with wild-type.

      Survival data from virgin females expressing GlΔ.Scer\UAS in motor neurons under the control of Scer\GAL4D42 generated on standard laboratory food demonstrate that Gl1 mutants have significant reduction in survival including changes in median and maximum lifespan compared with wild-type.

      Flies expressing GlΔ.Scer\UAS in CM9 motor neurons under the control of Scer\GAL4E49 exhibit an accelerated decline in motor function with age. Quantification of the proboscis extension reflex shows no significant difference at 7 and 21 days of age between mutant and control flies. However, analysis from days 21 and 42 show an accelerated deterioration of proboscis extension in Scer\GAL4E49>GlΔ.Scer\UAS flies which results in a highly significant reduction in the rate of motor reflex response.

      Flies expression Scer\GAL4E49>GlΔ.Scer\UAS exhibit progressive deterioration of proboscis muscle CM9 neuromuscular junctions (NMJs). Unlike in wild-type, synaptic area significantly decreases in the mutant with age. The mutant presynaptic nerve terminals appear disorganised in 72 day old flies compared with wild-type. The mutant NMJs display significantly more presynaptic sprouts per CM9 NMJ compared with controls at both 21 and 42 days of age. The number of synaptic retractions per CM9 NMJ is only increased at 42 day old mutant NMJs compared with wild-type. No abnormal age related changes are seen in the number of myo-nuclei, or gross organization of T-tubules in the mutant muscle compared to wild-type. Bristle-tracking reveals that Scer\GAL4E49>GlΔ.Scer\UAS flies have a significant reduction in average proboscis velocity compared with age-matched controls.

      Scer\GAL4E49>GlΔ.Scer\UAS mutant CM9 NMJs have impaired neurotransmission. The average amplitudes of evoked endplate junctional potentials (EJPs) are significantly reduced at NMJs from Scer\GAL4E49>GlΔ.Scer\UAS flies compared with wild-type. The amplitudes of miniature EJPs (mEJPs), also referred to as quantal size, are found to significantly reduced at the NMJs in the mutant flies raised at diluted (0.5X) diet compared with wild-type flies on the same diet. Analysis of quantal content, a measure of presynaptic release determined by dividing the EJP amplitudes by the mEJP amplitudes, reveals no significant difference in vesicle release in mutant flies compared to controls.

      (Rawson et al., 2012)

      Expression of GlΔ.Scer\UAS under the control of Scer\GAL4Ccap.PP results in a failure of wing expansion.

      (Bohm et al., 2010)

      Expression of GlΔ.Scer\UAS under the control of Scer\GAL4OK6 results in neuromuscular junctions indistinguishable from wild-type. At 7 and 9 hours after puparium formation there is no obvious change in synaptic vesicle distribution (compared to a redistribution in wild-type). These mutants also show considerably larger synaptic areas compared to wild-type.

      (Liu et al., 2010)

      The number of SE2 neurons is normal in animals expressing GlΔ.Scer\UAS under the control of Scer\GAL4elav-C155.

      (Losada-Pérez et al., 2010)

      Axonal sprouting of the injured axon after a crush injury to the segmental nerve in third instar larvae is significantly inhibited in animals expressing GlΔ.Scer\UAS under the control of Scer\GAL4unspecified.

      (Xiong et al., 2010)

      Expression of GlΔ.Scer\UAS under the control of Scer\GAL4GMR.PF results in adult flies with smaller eyes than normal. The eyes contain fused ommatidia and misarrayed eye bristles.

      Adults expressing GlΔ.Scer\UAS under the control of Scer\GAL4A307 have defects in giant fiber axon morphology; the characteristic terminal bend is missing and the axon tips are swollen.

      Adults expressing GlΔ.Scer\UAS under the control of Scer\GAL4A307 have electrophysiological defects in the giant fiber system; some flies fail to respond to brain stimulation and those that do respond show a long response latency and show only a single response or poor following to repetitive stimuli

      (Ma et al., 2009)

      Targeted expression of GlΔ.Scer\UAS driven by Scer\GAL4αTub84B.PP results in abnormalities in the architecture of the CSD interneuron (CSDn). The ipsilateral dendrites are greatly increased in number and the presynaptic terminals are reduced compared to wild-type.

      (Roy et al., 2007)

      Expression of GlΔ.Scer\UAS in the developing eye using the MARCM system (under the control of Scer\GAL4Act5C.PP) has a modest effect on R7 tiling.

      (Ting et al., 2007)

      Expression of GlΔ.Scer\UAS in the presynaptic membrane, driven by Scer\GAL4elav-C155, causes an increase in the rate of synapse retraction.

      (Pielage et al., 2005)

      In the retinal photoreceptors of late third instar GlΔ.Scer\UAS; Scer\GAL4Glass38-1 larvae, the region of the photoreceptor containing the nucleus often leaves the retina and travels through the optic stalk towards the brain. Bolwig's organ photoreceptor nuclei in second instar GlΔ.Scer\UAS; Scer\GAL4elav.PLu larvae are mislocalised: instead of being located at the anterior tip of the larva they sit on the surface of the eye/antennal disc.

      (Whited et al., 2004)

      When GlΔ.Scer\UAS is driven by Scer\GAL4ap-md544, a blockade of axonal transport is seen in the embryonic nervous system.

      (Allan et al., 2003)

      When GlΔ.Scer\UAS is driven by Scer\GAL4dimm-929 animals survive to pupal stage and about 50% eclose. Many of the eclosed adults exhibit uncoordinated movements and some do not inflate their wings.

      (Marques et al., 2003)

      GlΔ.Scer\UAS; Scer\GAL4elav-C155 animals have normal patterns of motor neuron fasciculation and innervation of target muscles. However at the third instar larval stage they have small synapses at neuromuscular junctions and detachments of the pre- and postsynaptic membrane around active zones.

      (McCabe et al., 2003)

      The addition of GlΔ.Scer\UAS driven by Scer\GAL4elav-C155 leads to an increase in synaptic fingerprints (seen after synapses retract) at the synapses of muscles 6 and 7. No significant effect is seen on numbers of apoptotic nuclei in these animals. There are disruptions seen specifically in the presynaptic microtubule skeleton. When GlΔ.Scer\UAS is driven by Scer\GAL4elav-C155, a reduction of more than 30% is seen in boutons per synapse (at the neuromuscular junctions of muscles 6 and 7). Active zone number per bouton is also decreased by about 50% compared to wild-type. Presynaptic boutons are filled with large vesicles and vacuoles of varying size. Post-synaptically the subsynaptic membrane folds (SSR) are much less compact than seen in wild-type, and can be invaded my mitochondrion. In the distal regions of the synapse, with severe SSR disruption, the presynaptic profiles are often very small and devoid of fully formed active zones. Also an 8 fold increase in the percentage of active zone that is detached is seen. When GlΔ.Scer\UAS is driven by Scer\GAL4elav-C155, No alteration is seen in quantal size or mEPSP frequency, but quantal content is reduced by about 40%. When GlΔ.Scer\UAS is driven by Scer\GAL4elav-C155 no effect on synaptic development or bouton size is seen.

      (Eaton et al., 2002)

      When expression is driven by Scer\GAL4c311 and the larvae raised at 29oC the larval lethality is fully penetrant and the eye disc phenotype is severely enhanced. Morphogenetic furrow progression is reduced or eliminated, and mitotic patterns are disrupted. Eye development is not completely blocked.

      (Gibson and Schubiger, 2000)

      When expression is driven in the eye by Scer\GAL4GMR.PF or Scer\GAL4hs.2sev the eyes are reduced and roughened. When expression is driven by Scer\GAL4A307 the giant fibers fail to show their characteristic bend in the second thoracic neuromere, and the axons have swellings at their terminals of up to three times the normal axon diameter. The axons are distorted by large vesicles. Arborization of the dendritic field is normal. When expression is driven by Scer\GAL4c17 a similar, though less extreme, phenotype is seen to that caused when expression is driven by Scer\GAL4A307. These abnormalities in giant fibers appear late in development. Morphology is normal up to 24hr APF, indicating no defects in growth and pathfinding in the brain and connective. By 48hr APF the defects are becoming apparent. When expression is driven by Scer\GAL4c17 or Scer\GAL4A307 dye coupling between the giant fibre and the TTM (tergotrochanteral motoneuron) is reduced and abolished, respectively. When expression is driven by Scer\GAL4c17 or Scer\GAL4A307 and the GF-TTM synapse characteristics are examined, changes occur in response latency (becomes variable), refractory period (increased) and following frequency (decreased). The effect is more pronounced for Scer\GAL4A307 than for Scer\GAL4c17. DLM muscle response is normal.

      (Allen et al., 1999)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Statement
      Reference

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has abnormal neuroanatomy | third instar larval stage phenotype, enhanceable by ArfipEY11874

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has abnormal neuroanatomy | third instar larval stage phenotype, enhanceable by fanc04756

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has abnormal neuroanatomy | third instar larval stage phenotype, enhanceable by P{EPgy2}wallEY20330

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has abnormal neuroanatomy | third instar larval stage phenotype, enhanceable by CoopEY13293

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has abnormal neuroanatomy | third instar larval stage phenotype, enhanceable by Sirt2c03323

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has abnormal neuroanatomy | third instar larval stage phenotype, enhanceable by B4EY14645

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has abnormal neuroanatomy | third instar larval stage phenotype, enhanceable by nesdEY11086

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has abnormal neuroanatomy | third instar larval stage phenotype, enhanceable by bbgEY05191

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has abnormal neuroanatomy | third instar larval stage phenotype, enhanceable by Arfipd04252

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has abnormal neuroanatomy | third instar larval stage phenotype, enhanceable by P{EPgy2}EY12448

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has abnormal neuroanatomy | third instar larval stage phenotype, enhanceable by klarEY01576

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has abnormal neuroanatomy | third instar larval stage phenotype, enhanceable by TM9SF4EY00960

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has abnormal neuroanatomy | third instar larval stage phenotype, enhanceable by ArfipUAS.WT, Scer\GAL4Toll-6-D42

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has abnormal neuroanatomy | third instar larval stage phenotype, enhanceable by Arfip12

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has abnormal neuroanatomy | third instar larval stage phenotype, enhanceable by Mrp5EY09703

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has abnormal neuroanatomy | third instar larval stage phenotype, enhanceable by NaPi-IIIEY04050

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4GMR.PF has visible phenotype, enhanceable by Su(H)[+]/Su(H)EG37

      (Ma et al., 2009)

      DCTN1-p150Δ.UAS, Scer\GAL4GMR.PF has visible phenotype, enhanceable by EG149EG149/EG149[+]

      (Ma et al., 2009)

      DCTN1-p150Δ.UAS, Scer\GAL4GMR.PF has visible phenotype, enhanceable by EG162[+]/EG162EG162

      (Ma et al., 2009)

      DCTN1-p150Δ.UAS, Scer\GAL4GMR.PF has visible phenotype, enhanceable by EG28EG28/EG28[+]

      (Ma et al., 2009)

      DCTN1-p150Δ.UAS, Scer\GAL4GMR.PF has visible phenotype, enhanceable by EG165[+]/EG165EG165

      (Ma et al., 2009)

      DCTN1-p150Δ.UAS, Scer\GAL4GMR.PF has visible phenotype, enhanceable by EG7[+]/EG7EG7

      (Ma et al., 2009)

      DCTN1-p150Δ.UAS, Scer\GAL4GMR.PF has visible phenotype, enhanceable by EG56EG56/EG56[+]

      (Ma et al., 2009)

      DCTN1-p150Δ.UAS, Scer\GAL4GMR.PF has visible phenotype, enhanceable by EG79[+]/EG79EG79

      (Ma et al., 2009)
      NOT Enhanced by
      Statement
      Reference

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has abnormal neuroanatomy | third instar larval stage phenotype, non-enhanceable by bbgEY08296

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has abnormal neuroanatomy | third instar larval stage phenotype, non-enhanceable by klarEY00559

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has abnormal neuroanatomy | third instar larval stage phenotype, non-enhanceable by P{EPgy2}EY09113

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has abnormal neuroanatomy | third instar larval stage phenotype, non-enhanceable by HGTXd00083

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has abnormal neuroanatomy | third instar larval stage phenotype, non-enhanceable by P{EPgy2}EY13479

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has abnormal neuroanatomy | third instar larval stage phenotype, non-enhanceable by CG16986f06804

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has abnormal neuroanatomy | third instar larval stage phenotype, non-enhanceable by P{EPgy2}EY00794

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has abnormal neuroanatomy | third instar larval stage phenotype, non-enhanceable by P{EPgy2}EY10300

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has abnormal neuroanatomy | third instar larval stage phenotype, non-enhanceable by pxEY03862

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has abnormal neuroanatomy | third instar larval stage phenotype, non-enhanceable by exEY08756

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has abnormal neuroanatomy | third instar larval stage phenotype, non-enhanceable by Sik3EY06260

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has abnormal neuroanatomy | third instar larval stage phenotype, non-enhanceable by Antpd06610

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has abnormal neuroanatomy | third instar larval stage phenotype, non-enhanceable by CG3635EY20874

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has abnormal neuroanatomy | third instar larval stage phenotype, non-enhanceable by CG18231f03022

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has abnormal neuroanatomy | third instar larval stage phenotype, non-enhanceable by CenG1AEY10943

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has abnormal neuroanatomy | third instar larval stage phenotype, non-enhanceable by P{EPgy2}EY09719

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has abnormal neuroanatomy | third instar larval stage phenotype, non-enhanceable by chbEY22501

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has abnormal neuroanatomy | third instar larval stage phenotype, non-enhanceable by LamEY08333

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has abnormal neuroanatomy | third instar larval stage phenotype, non-enhanceable by Mic26-27EY11938

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has abnormal neuroanatomy | third instar larval stage phenotype, non-enhanceable by Leashd02595

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has abnormal neuroanatomy | third instar larval stage phenotype, non-enhanceable by ichEY06009

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has abnormal neuroanatomy | third instar larval stage phenotype, non-enhanceable by pnsEY05553

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has abnormal neuroanatomy | third instar larval stage phenotype, non-enhanceable by ichEY16110

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has abnormal neuroanatomy | third instar larval stage phenotype, non-enhanceable by Pif1EY10295

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4shot-OK307 has abnormal neuroanatomy | adult stage phenotype, non-enhanceable by EG28EG28/EG28[+]

      (Ma et al., 2009)
      Suppressed by
      Statement
      Reference

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has abnormal neuroanatomy | third instar larval stage phenotype, suppressible by P{EPgy2}EY06888

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has abnormal neuroanatomy | third instar larval stage phenotype, suppressible by AkhREY11371

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4CCAP.PP has visible phenotype, suppressible by Scer\GAL80αTub84B.PB

      (Bohm et al., 2010)

      DCTN1-p150Δ.UAS, Scer\GAL4GMR.PF has visible phenotype, suppressible by SG13SG13/SG13[+]

      (Ma et al., 2009)

      DCTN1-p150Δ.UAS, Scer\GAL4GMR.PF has visible phenotype, suppressible by SG16[+]/SG16SG16

      (Ma et al., 2009)

      DCTN1-p150Δ.UAS, Scer\GAL4GMR.PF has visible phenotype, suppressible by SG46[+]/SG46SG46

      (Ma et al., 2009)

      DCTN1-p150Δ.UAS, Scer\GAL4GMR.PF has visible phenotype, suppressible by aPKCSG58/aPKC[+]

      (Ma et al., 2009)

      DCTN1-p150Δ.UAS, Scer\GAL4shot-OK307 has abnormal neuroanatomy | adult stage phenotype, suppressible by SG13SG13/SG13[+]

      (Ma et al., 2009)

      DCTN1-p150Δ.UAS, Scer\GAL4shot-OK307 has abnormal neuroanatomy | adult stage phenotype, suppressible by SG46[+]/SG46SG46

      (Ma et al., 2009)

      DCTN1-p150Δ.UAS, Scer\GAL4shot-OK307 has abnormal neuroanatomy | adult stage phenotype, suppressible by aPKCSG58/aPKC[+]

      (Ma et al., 2009)

      DCTN1-p150Δ.UAS, Scer\GAL4shot-OK307 has abnormal neurophysiology | adult stage phenotype, suppressible by SG13SG13/SG13[+]

      (Ma et al., 2009)

      DCTN1-p150Δ.UAS, Scer\GAL4shot-OK307 has abnormal neurophysiology | adult stage phenotype, suppressible by SG46[+]/SG46SG46

      (Ma et al., 2009)

      DCTN1-p150Δ.UAS, Scer\GAL4shot-OK307 has abnormal neurophysiology | adult stage phenotype, suppressible by aPKCSG58/aPKC[+]

      (Ma et al., 2009)

      DCTN1-p150Δ.UAS, Scer\GAL4shot-OK307 has abnormal neuroanatomy | adult stage phenotype, suppressible by aPKCk06403/aPKC[+]

      (Ma et al., 2009)

      DCTN1-p150Δ.UAS, Scer\GAL4shot-OK307 has abnormal neuroanatomy | adult stage phenotype, suppressible by aPKCEY22946/aPKC[+]

      (Ma et al., 2009)
      NOT suppressed by
      Statement
      Reference

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has abnormal neuroanatomy | third instar larval stage phenotype, non-suppressible by P{EPgy2}EY09719

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has abnormal neuroanatomy | third instar larval stage phenotype, non-suppressible by Mic26-27EY11938

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has abnormal neuroanatomy | third instar larval stage phenotype, non-suppressible by Leashd02595

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has abnormal neuroanatomy | third instar larval stage phenotype, non-suppressible by ichEY06009

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has abnormal neuroanatomy | third instar larval stage phenotype, non-suppressible by chbEY22501

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has abnormal neuroanatomy | third instar larval stage phenotype, non-suppressible by LamEY08333

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has abnormal neuroanatomy | third instar larval stage phenotype, non-suppressible by bbgEY08296

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has abnormal neuroanatomy | third instar larval stage phenotype, non-suppressible by klarEY00559

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has abnormal neuroanatomy | third instar larval stage phenotype, non-suppressible by P{EPgy2}EY09113

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has abnormal neuroanatomy | third instar larval stage phenotype, non-suppressible by pnsEY05553

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has abnormal neuroanatomy | third instar larval stage phenotype, non-suppressible by HGTXd00083

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has abnormal neuroanatomy | third instar larval stage phenotype, non-suppressible by P{EPgy2}EY13479

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has abnormal neuroanatomy | third instar larval stage phenotype, non-suppressible by CG16986f06804

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has abnormal neuroanatomy | third instar larval stage phenotype, non-suppressible by ichEY16110

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has abnormal neuroanatomy | third instar larval stage phenotype, non-suppressible by P{EPgy2}EY00794

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has abnormal neuroanatomy | third instar larval stage phenotype, non-suppressible by P{EPgy2}EY10300

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has abnormal neuroanatomy | third instar larval stage phenotype, non-suppressible by Pif1EY10295

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has abnormal neuroanatomy | third instar larval stage phenotype, non-suppressible by pxEY03862

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has abnormal neuroanatomy | third instar larval stage phenotype, non-suppressible by exEY08756

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has abnormal neuroanatomy | third instar larval stage phenotype, non-suppressible by Sik3EY06260

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has abnormal neuroanatomy | third instar larval stage phenotype, non-suppressible by Antpd06610

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has abnormal neuroanatomy | third instar larval stage phenotype, non-suppressible by CG3635EY20874

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has abnormal neuroanatomy | third instar larval stage phenotype, non-suppressible by CG18231f03022

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has abnormal neuroanatomy | third instar larval stage phenotype, non-suppressible by CenG1AEY10943

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4CCAP.PP has visible phenotype, non-suppressible by Scer\GAL80FRT.αTub84B

      (Bohm et al., 2010)

      DCTN1-p150Δ.UAS, Scer\GAL4shot-OK307 has abnormal neuroanatomy | adult stage phenotype, non-suppressible by SG16[+]/SG16SG16

      (Ma et al., 2009)
      Other
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has type Ib terminal bouton | third instar larval stage phenotype, enhanceable by ArfipEY11874

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has type Ib terminal bouton | third instar larval stage phenotype, enhanceable by fanc04756

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has type Ib terminal bouton | third instar larval stage phenotype, enhanceable by P{EPgy2}wallEY20330

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has type Ib terminal bouton | third instar larval stage phenotype, enhanceable by CoopEY13293

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has type Ib terminal bouton | third instar larval stage phenotype, enhanceable by Sirt2c03323

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has type Ib terminal bouton | third instar larval stage phenotype, enhanceable by B4EY14645

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has type Ib terminal bouton | third instar larval stage phenotype, enhanceable by nesdEY11086

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has type Ib terminal bouton | third instar larval stage phenotype, enhanceable by bbgEY05191

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has type Ib terminal bouton | third instar larval stage phenotype, enhanceable by Arfipd04252

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has type Ib terminal bouton | third instar larval stage phenotype, enhanceable by P{EPgy2}EY12448

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has type Ib terminal bouton | third instar larval stage phenotype, enhanceable by klarEY01576

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has type Ib terminal bouton | third instar larval stage phenotype, enhanceable by TM9SF4EY00960

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has type Ib terminal bouton | third instar larval stage phenotype, enhanceable by ArfipUAS.WT, Scer\GAL4Toll-6-D42

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has type Ib terminal bouton | third instar larval stage phenotype, enhanceable by Arfip12

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has type Ib terminal bouton | third instar larval stage phenotype, enhanceable by Mrp5EY09703

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has type Ib terminal bouton | third instar larval stage phenotype, enhanceable by NaPi-IIIEY04050

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4GMR.PF has eye phenotype, enhanceable by Su(H)[+]/Su(H)EG37

      (Ma et al., 2009)

      DCTN1-p150Δ.UAS, Scer\GAL4GMR.PF has eye phenotype, enhanceable by EG149EG149/EG149[+]

      (Ma et al., 2009)

      DCTN1-p150Δ.UAS, Scer\GAL4GMR.PF has eye phenotype, enhanceable by EG162[+]/EG162EG162

      (Ma et al., 2009)

      DCTN1-p150Δ.UAS, Scer\GAL4GMR.PF has eye phenotype, enhanceable by EG28EG28/EG28[+]

      (Ma et al., 2009)

      DCTN1-p150Δ.UAS, Scer\GAL4GMR.PF has eye phenotype, enhanceable by EG165[+]/EG165EG165

      (Ma et al., 2009)

      DCTN1-p150Δ.UAS, Scer\GAL4GMR.PF has eye phenotype, enhanceable by EG7[+]/EG7EG7

      (Ma et al., 2009)

      DCTN1-p150Δ.UAS, Scer\GAL4GMR.PF has eye phenotype, enhanceable by EG56EG56/EG56[+]

      (Ma et al., 2009)

      DCTN1-p150Δ.UAS, Scer\GAL4GMR.PF has eye phenotype, enhanceable by EG79[+]/EG79EG79

      (Ma et al., 2009)

      DCTN1-p150Δ.UAS, Scer\GAL4Act5C.PP has photoreceptor cell R7 | somatic clone phenotype, enhanceable by sevV1

      (Ting et al., 2007)
      NOT Enhanced by
      Statement
      Reference

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has type Ib terminal bouton | third instar larval stage phenotype, non-enhanceable by klarEY00559

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has type Ib terminal bouton | third instar larval stage phenotype, non-enhanceable by P{EPgy2}EY09113

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has type Ib terminal bouton | third instar larval stage phenotype, non-enhanceable by HGTXd00083

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has type Ib terminal bouton | third instar larval stage phenotype, non-enhanceable by P{EPgy2}EY13479

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has type Ib terminal bouton | third instar larval stage phenotype, non-enhanceable by CG16986f06804

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has type Ib terminal bouton | third instar larval stage phenotype, non-enhanceable by P{EPgy2}EY00794

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has type Ib terminal bouton | third instar larval stage phenotype, non-enhanceable by P{EPgy2}EY10300

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has type Ib terminal bouton | third instar larval stage phenotype, non-enhanceable by pxEY03862

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has type Ib terminal bouton | third instar larval stage phenotype, non-enhanceable by exEY08756

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has type Ib terminal bouton | third instar larval stage phenotype, non-enhanceable by Sik3EY06260

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has type Ib terminal bouton | third instar larval stage phenotype, non-enhanceable by P{EPgy2}EY09719

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has type Ib terminal bouton | third instar larval stage phenotype, non-enhanceable by Antpd06610

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has type Ib terminal bouton | third instar larval stage phenotype, non-enhanceable by CG3635EY20874

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has type Ib terminal bouton | third instar larval stage phenotype, non-enhanceable by CG18231f03022

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has type Ib terminal bouton | third instar larval stage phenotype, non-enhanceable by CenG1AEY10943

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has type Ib terminal bouton | third instar larval stage phenotype, non-enhanceable by chbEY22501

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has type Ib terminal bouton | third instar larval stage phenotype, non-enhanceable by LamEY08333

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has type Ib terminal bouton | third instar larval stage phenotype, non-enhanceable by Mic26-27EY11938

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has type Ib terminal bouton | third instar larval stage phenotype, non-enhanceable by Leashd02595

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has type Ib terminal bouton | third instar larval stage phenotype, non-enhanceable by ichEY06009

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has type Ib terminal bouton | third instar larval stage phenotype, non-enhanceable by pnsEY05553

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has type Ib terminal bouton | third instar larval stage phenotype, non-enhanceable by bbgEY08296

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has type Ib terminal bouton | third instar larval stage phenotype, non-enhanceable by ichEY16110

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has type Ib terminal bouton | third instar larval stage phenotype, non-enhanceable by Pif1EY10295

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4shot-OK307 has giant fiber neuron phenotype, non-enhanceable by EG28EG28/EG28[+]

      (Ma et al., 2009)
      Suppressed by
      Statement
      Reference

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has type Ib terminal bouton | third instar larval stage phenotype, suppressible by P{EPgy2}EY06888

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has type Ib terminal bouton | third instar larval stage phenotype, suppressible by AkhREY11371

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4CCAP.PP has wing phenotype, suppressible by Scer\GAL80αTub84B.PB

      (Bohm et al., 2010)

      DCTN1-p150Δ.UAS, Scer\GAL4GMR.PF has eye phenotype, suppressible by SG13SG13/SG13[+]

      (Ma et al., 2009)

      DCTN1-p150Δ.UAS, Scer\GAL4GMR.PF has eye phenotype, suppressible by SG16[+]/SG16SG16

      (Ma et al., 2009)

      DCTN1-p150Δ.UAS, Scer\GAL4GMR.PF has eye phenotype, suppressible by SG46[+]/SG46SG46

      (Ma et al., 2009)

      DCTN1-p150Δ.UAS, Scer\GAL4GMR.PF has eye phenotype, suppressible by aPKCSG58/aPKC[+]

      (Ma et al., 2009)

      DCTN1-p150Δ.UAS, Scer\GAL4shot-OK307 has giant fiber neuron phenotype, suppressible by SG13SG13/SG13[+]

      (Ma et al., 2009)

      DCTN1-p150Δ.UAS, Scer\GAL4shot-OK307 has giant fiber neuron phenotype, suppressible by SG46[+]/SG46SG46

      (Ma et al., 2009)

      DCTN1-p150Δ.UAS, Scer\GAL4shot-OK307 has giant fiber neuron phenotype, suppressible by aPKCSG58/aPKC[+]

      (Ma et al., 2009)

      DCTN1-p150Δ.UAS, Scer\GAL4shot-OK307 has giant fiber neuron phenotype, suppressible by aPKCk06403/aPKC[+]

      (Ma et al., 2009)

      DCTN1-p150Δ.UAS, Scer\GAL4shot-OK307 has giant fiber neuron phenotype, suppressible by aPKCEY22946/aPKC[+]

      (Ma et al., 2009)

      DCTN1-p150Δ.UAS, Scer\GAL4Glass38-1 has eye photoreceptor cell & nucleus phenotype, suppressible | partially by Khc[+]/Khc8

      (Whited et al., 2004)

      DCTN1-p150Δ.UAS, Scer\GAL4elav.PLu has larval Bolwig's organ & nucleus phenotype, suppressible | partially by Khc[+]/Khc8

      (Whited et al., 2004)

      DCTN1-p150Δ.UAS, Scer\GAL4elav.PLu has larval Bolwig's organ & nucleus phenotype, suppressible | partially by Khc[+]/Khck13314

      (Whited et al., 2004)

      DCTN1-p150Δ.UAS, Scer\GAL4Glass38-1 has eye photoreceptor cell & nucleus phenotype, suppressible by Khc[+]/Khck13314

      (Whited et al., 2004)
      NOT suppressed by
      Statement
      Reference

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has type Ib terminal bouton | third instar larval stage phenotype, non-suppressible by P{EPgy2}EY09113

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has type Ib terminal bouton | third instar larval stage phenotype, non-suppressible by pnsEY05553

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has type Ib terminal bouton | third instar larval stage phenotype, non-suppressible by HGTXd00083

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has type Ib terminal bouton | third instar larval stage phenotype, non-suppressible by P{EPgy2}EY13479

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has type Ib terminal bouton | third instar larval stage phenotype, non-suppressible by CG16986f06804

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has type Ib terminal bouton | third instar larval stage phenotype, non-suppressible by ichEY16110

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has type Ib terminal bouton | third instar larval stage phenotype, non-suppressible by P{EPgy2}EY00794

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has type Ib terminal bouton | third instar larval stage phenotype, non-suppressible by P{EPgy2}EY10300

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has type Ib terminal bouton | third instar larval stage phenotype, non-suppressible by Pif1EY10295

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has type Ib terminal bouton | third instar larval stage phenotype, non-suppressible by pxEY03862

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has type Ib terminal bouton | third instar larval stage phenotype, non-suppressible by P{EPgy2}EY09719

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has type Ib terminal bouton | third instar larval stage phenotype, non-suppressible by exEY08756

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has type Ib terminal bouton | third instar larval stage phenotype, non-suppressible by Sik3EY06260

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has type Ib terminal bouton | third instar larval stage phenotype, non-suppressible by Antpd06610

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has type Ib terminal bouton | third instar larval stage phenotype, non-suppressible by CG3635EY20874

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has type Ib terminal bouton | third instar larval stage phenotype, non-suppressible by CG18231f03022

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has type Ib terminal bouton | third instar larval stage phenotype, non-suppressible by CenG1AEY10943

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has type Ib terminal bouton | third instar larval stage phenotype, non-suppressible by Mic26-27EY11938

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has type Ib terminal bouton | third instar larval stage phenotype, non-suppressible by Leashd02595

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has type Ib terminal bouton | third instar larval stage phenotype, non-suppressible by ichEY06009

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has type Ib terminal bouton | third instar larval stage phenotype, non-suppressible by chbEY22501

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has type Ib terminal bouton | third instar larval stage phenotype, non-suppressible by LamEY08333

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has type Ib terminal bouton | third instar larval stage phenotype, non-suppressible by bbgEY08296

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4Toll-6-D42 has type Ib terminal bouton | third instar larval stage phenotype, non-suppressible by klarEY00559

      (Chang et al., 2013)

      DCTN1-p150Δ.UAS, Scer\GAL4CCAP.PP has wing phenotype, non-suppressible by Scer\GAL80FRT.αTub84B

      (Bohm et al., 2010)

      DCTN1-p150Δ.UAS, Scer\GAL4shot-OK307 has giant fiber neuron phenotype, non-suppressible by SG16[+]/SG16SG16

      (Ma et al., 2009)
      Other
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      Genetic Interactions
      Statement
      Reference

      The reduction in the number of type 1b boutons at the neuromuscular junction seen in third-instar larvae expressing GlΔ.Scer\UAS under the control of Scer\GAL4D42 is enhanced if the flies are also carrying a single copy of CG4562EY09703, bbgEY05191, Arfipd04252, Arfip12, klarEY01576, CG42575EY04050 or TM9SF4EY00960.

      The reduction in the number of type 1b boutons at the neuromuscular junction seen in third-instar larvae expressing GlΔ.Scer\UAS under the control of Scer\GAL4D42 is enhanced if the flies are also carrying a single copy of ArfipEY11874, P{EPgy2}EY20330 or CoopEY13293. The number of synaptic retractions is suppressed.

      The reduction in the number of type 1b boutons at the neuromuscular junction seen in third-instar larvae expressing GlΔ.Scer\UAS under the control of Scer\GAL4D42 is enhanced if the flies are also carrying a single copy of fanc04756, Sirt2c03323, B4EY14645, nesdEY11086 or P{EPgy2}EY12448. The number of synaptic retractions is also enhanced.

      The reduction in the number of type 1b boutons at the neuromuscular junction seen in third-instar larvae expressing GlΔ.Scer\UAS under the control of Scer\GAL4D42 is suppressed if the flies are also carrying a single copy of P{EPgy2}EY06888 or AkhREY11371. The number of synaptic retractions are also suppressed.

      Co-expression of ArfipScer\UAS.WT enhances the reduction in the number of type 1b boutons at the neuromuscular junction seen in third-instar larvae expressing GlΔ.Scer\UAS under the control of Scer\GAL4D42.

      (Chang et al., 2013)

      Scer\GAL80Scer\FRT.αTub84B has no effect on the wing expansion defect caused by expression of GlΔ.Scer\UAS under the control of Scer\GAL4Ccap.PP. When FLPase is used to remove the Scer\FRT cassette in Scer\GAL80Scer\FRT.αTub84B, generating Scer\GAL80αTub84B.PB which expresses Scer\GAL80, the failure of wing expansion caused by expression of GlΔ.Scer\UAS under the control of Scer\GAL4Ccap.PP is completely suppressed.

      (Bohm et al., 2010)

      The eye phenotype caused by expression of GlΔ.Scer\UAS under the control of Scer\GAL4GMR.PF is dominantly suppressed by SG13SG13, SG16SG16, SG46SG46 or aPKCSG58.

      The eye phenotype caused by expression of GlΔ.Scer\UAS under the control of Scer\GAL4GMR.PF is dominantly enhanced by EG162EG162, Su(H)EG37, EG28EG28, EG165EG165, EG7EG7, EG56EG56, EG79EG79 or EG149EG149.

      Both the lack of a terminal bend and the swollen axon tip phenotypes of giant fiber axons that are seen in adults expressing GlΔ.Scer\UAS under the control of Scer\GAL4A307 are suppressed by either SG13SG13/+ or SG46SG46/+.

      aPKCSG58/+ mildly suppresses the swollen tip phenotype of giant fiber axons expressing GlΔ.Scer\UAS under the control of Scer\GAL4A307, but the lack of a terminal bend phenotype is not rescued.

      The giant fiber axon defects seen in adults expressing GlΔ.Scer\UAS under the control of Scer\GAL4A307 are not rescued by SG16SG16/+.

      The giant fiber axon defects seen in adults expressing GlΔ.Scer\UAS under the control of Scer\GAL4A307 are partially suppressed by aPKCk06403/+ and by aPKCEY22946/+.

      20% of giant fiber axons fail to exit the brain in adults expressing GlΔ.Scer\UAS under the control of Scer\GAL4A307 in a EG28EG28/+ background.

      Heterozygosity for SG13SG13 or SG46SG46 partially suppresses the giant fiber system electrophysiological defects in animals expressing GlΔ.Scer\UAS under the control of Scer\GAL4A307; all preparations respond to brain stimulation and the response latency is shorter than in flies expressing GlΔ.Scer\UAS under the control of Scer\GAL4A307 in a wild-type background.

      Heterozygosity for aPKCSG58 partially suppresses the giant fiber system electrophysiological defects in animals expressing GlΔ.Scer\UAS under the control of Scer\GAL4A307; all preparations respond to stimulation, there is a slight reduction in the long response latency and a corresponding increase in following to repetitive stimuli.

      (Ma et al., 2009)

      When neighboring wild-type R7 axons are removed through the presence of sevV1, GlΔ.Scer\UAS mutant R7 axons extend into adjacent columns.

      (Ting et al., 2007)

      The loss of photoreceptor nuclei from the retina in late third instar GlΔ.Scer\UAS; Scer\GAL4Glass38-1 larvae is significantly suppressed by Khck13314/+ and almost completely suppressed by Khc8/+. Mislocalisation of the Bolwig's organ nuclei in GlΔ.Scer\UAS/Scer\GAL4elav.PLu second instar larvae is partially suppressed by Khck13314/+ or Khc8/+.

      (Whited et al., 2004)
      Xenogenetic Interactions
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      Complementation and Rescue Data
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      Stocks (1)
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      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      DCTN1-p150Δ.Scer\UAS
      DCTN1-p150Δ.UAS
      GlΔ.Scer\UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (38)