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General Information
Symbol
Dmel\Appls.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0103099
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-Appls
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

Deletion of the transmembrane domain, Gobinding domain and internalization signal of the Appl coding region. Encodes a secreted for of Appl.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Overexpression of Appls.Scer\UAS under the control of Scer\GAL4Mef2.247.Switch leads to wild-type memory performance.

Expression of Appls.Scer\UAS under the control of Scer\GAL4Bx-MS1096 has no effect on the size of the wing.

When expression of two copies of P{UAS-Appl.s} is driven in the motoneurons muscles 6 and 7 (abdominal segment 3) total number of synaptic boutons is slightly increased, percentage of satellite boutons is decreased and the number of normal boutons is slightly increased.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

Expression of Appls.Scer\UAS in a heterozygous Appld/+;Scer\GAL4Mef2.247.Switch background suppresses the short term memory defect seen in this background, even in flies that have not been fed RU.

RU-induced expression of Applsd.Scer\UAS under the control of Scer\GAL4Mef2.247.Switch fails to rescue the long term memory deficit caused by Appld/+ partial loss-of-function.

Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
Appls.Scer\UAS
Appls.UAS
Name Synonyms
Secondary FlyBase IDs
    References (5)