Allele Dmel\th^SL

General Information
Symbol	Dmel\th^SL	Species	D. melanogaster
Name		FlyBase ID	FBal0103508
Feature type	allele	Associated gene	Dmel\th

Map ( GBrowse )
Allele class	hypermorphic allele - genetic evidence, loss of function allele, gain of function allele
Mutagen	ethyl methanesulfonate
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class	gain of function allele (Lisi et al., 2000) hypermorphic allele - genetic evidence (Choi et al., 2006) loss of function allele (Lisi et al., 2000)
Mutagen	ethyl methanesulfonate (Lisi et al., 2000)
Mutations Mapped to the Genome

Type Location Additional Notes References point mutation 3L:16,032,836..16,032,836 comment=Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. V85 falls in the BIR1 domain. evidence=experimental na_change=G16032836A pr_change=V85M\|th-PC,V85M\|th-PB,V85M\|th-PA reported_pr_change=V85M (Lisi et al., 2000)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Amino acid replacement: V85M. V85 falls in the BIR1 domain. (Lisi et al., 2000)
Cytology
Phenotypic Data
Phenotypic Class
	viable (Lisi et al., 2000)
Phenotype Manifest In

Detailed Description
	Statement Reference th^SL mutants exhibit normal levels of cell death in Crz-expressing ventral nerve cord neurons. (Choi et al., 2006)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement Reference th^SL is an enhancer of cell death defective phenotype of W^GMR.PG/W^GMR.PG (Lisi et al., 2000) th^SL is an enhancer of cell death defective phenotype of W^hs.PG (Lisi et al., 2000) th^SL is an enhancer of visible phenotype of Hsap\MAPT^{V337M.Scer\UAS}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Shulman and Feany, 2003)
Suppressor of
Statement Reference th^SL is a suppressor \| partially of increased cell death phenotype of Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, rpr^Scer\UAS.cZa (Wing et al., 2001) th^SL is a suppressor \| partially of visible phenotype of Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, rpr^Scer\UAS.cZa (Wing et al., 2001) th^SL is a suppressor of cell death defective phenotype of grim^GMR.PC (Lisi et al., 2000) th^SL is a suppressor of cell death defective phenotype of rpr^GMR.PW (Lisi et al., 2000) th^SL is a suppressor of cell death defective phenotype of rpr^hs.PW (Lisi et al., 2000) th^SL is a suppressor of lethal phenotype of Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, rpr^Scer\UAS.cZa (Wing et al., 2001)
NOT Suppressor of
Statement Reference Scer\GAL4^GMR.PF, Scer\GAL4^GMR.PF, th^SL is a non-suppressor of lethal phenotype of Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, grim^Scer\UAS.cNa (Wing et al., 2001) th^SL is a non-suppressor of lethal phenotype of Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, W^Scer\UAS.cZa (Wing et al., 2001)
Other
Statement Reference rpr^hs.PW, th^SL has viable phenotype (Lisi et al., 2000)
Phenotype Manifest In
Enhancer of
Statement Reference th^SL is an enhancer of adult phenotype of W^hs.PG (Lisi et al., 2000) th^SL is an enhancer of embryo phenotype of W^hs.PG (Lisi et al., 2000) th^SL is an enhancer of eye phenotype of Hsap\MAPT^{V337M.Scer\UAS}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Shulman and Feany, 2003) th^SL is an enhancer of eye phenotype of W^GMR.PG/W^GMR.PG (Lisi et al., 2000) th^SL is an enhancer of ommatidium phenotype of Hsap\MAPT^{V337M.Scer\UAS}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Shulman and Feany, 2003)
Suppressor of
Statement Reference th^SL is a suppressor \| partially of eye phenotype of Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, rpr^Scer\UAS.cZa (Wing et al., 2001) th^SL is a suppressor of embryo phenotype of rpr^hs.PW (Lisi et al., 2000) th^SL is a suppressor of eye phenotype of grim^GMR.PC (Lisi et al., 2000) th^SL is a suppressor of eye phenotype of rpr^GMR.PW (Lisi et al., 2000)
NOT Suppressor of
Statement Reference th^SL is a non-suppressor of phenotype of Hsap\CDKN1A^GMR.PH (Lisi et al., 2000)
Additional Comments
Genetic Interactions
Statement Reference Suppression of rpr^GMR.PW and grim^GMR.PC in the eye is almost complete though enhancement of W^GMR.PG is mild. Increases the viability of rpr^hs.PW flies threefold, but slightly enhances W^hs.PG-induced death. (Lisi et al., 2000)
Xenogenetic Interactions
Statement Reference The rough eye phenotype caused by expression of Hsap\MAPT^{V337M.Scer\UAS} under the control of Scer\GAL4^GMR.PF is enhanced by th^SL. (Shulman and Feany, 2003)
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

Comments
	Behaves as a gain of function allele with respect to rpr- and grim-induced cell death. Behaves as a weak loss of function with respect to W-induced cell death: in the eye and the embryo W-induced cell death is not inhibited by th^SL, it is enhanced. (Lisi et al., 2000)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	th^sl (Wing et al., 2001) th^SL (Choi et al., 2006)
Name Synonym
Secondary FlyBase IDs

References ( 4 )
Research paper	Choi et al., 2006, Development 133(11): 2223--2232 Programmed cell death mechanisms of identifiable peptidergic neurons in Drosophila melanogaster. [FBrf0190281] Shulman and Feany, 2003, Genetics 165(3): 1233--1242 Genetic modifiers of tauopathy in Drosophila. [FBrf0167629] Wing et al., 2001, Mech. Dev. 102(1-2): 193--203 The RHG motifs of Drosophila Reaper and Grim are important for their distinct cell death-inducing abilities. [FBrf0135877] Lisi et al., 2000, Genetics 154(2): 669--678 Diverse domains of THREAD/DIAP1 are required to inhibit apoptosis induced by REAPER and HID in Drosophila. [FBrf0125418]

Allele Dmel\thSL

Allele Dmel\th^SL