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General Information
Symbol
Dmel\Diap1SL
Species
D. melanogaster
Name
FlyBase ID
FBal0103508
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
thsl
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

G16039736A

Amino acid change:

V85M | Diap1-PA; V85M | Diap1-PB; V85M | Diap1-PC; V85M | Diap1-PD; V85M | Diap1-PE; V85M | Diap1-PF

Reported amino acid change:

V85M

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. V85 falls in the BIR1 domain.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: V85M. V85 falls in the BIR1 domain.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

As in wild type, thSL mutant bursCCAP neurons undergo programmed cell death shortly after eclosion.

thSL mutants exhibit normal levels of cell death in Crz-expressing ventral nerve cord neurons.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference
Suppressor of
NOT Suppressor of
Other
Statement
Reference
Phenotype Manifest In
Enhancer of
Statement
Reference
Suppressor of
Statement
Reference

Diap1SL is a suppressor of eye phenotype of rprGMR.PW

Diap1SL is a suppressor of embryo phenotype of rprhs.PW

Diap1SL is a suppressor of eye phenotype of grimGMR.PC

NOT Suppressor of
Statement
Reference

Diap1SL is a non-suppressor of phenotype of Hsap\CDKN1AGMR.PH

Additional Comments
Genetic Interactions
Statement
Reference

Suppression of rprGMR.PW and grimGMR.PC in the eye is almost complete though enhancement of WGMR.PG is mild. Increases the viability of rprhs.PW flies threefold, but slightly enhances Whs.PG-induced death.

Xenogenetic Interactions
Statement
Reference

The rough eye phenotype caused by expression of Hsap\MAPTV337M.Scer\UAS under the control of Scer\GAL4GMR.PF is enhanced by thSL.

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

Behaves as a gain of function allele with respect to rpr- and grim-induced cell death. Behaves as a weak loss of function with respect to W-induced cell death: in the eye and the embryo W-induced cell death is not inhibited by thSL, it is enhanced.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (5)