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General Information
Symbol
Dmel\Diap19
Species
D. melanogaster
Name
FlyBase ID
FBal0103509
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

C16039825T

Amino acid change:

P55L | Diap1-PA; P55L | Diap1-PB; P55L | Diap1-PC; P55L | Diap1-PD; P55L | Diap1-PE; P55L | Diap1-PF

Reported amino acid change:

P55L

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. Retains the V85M mutation in BIR1 of progenitor thSL.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Mutation falls in the BIR1 domain. Retains the V85M mutation in BIR1 of progenitor Diap1SL.

Amino acid replacement: P55L.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Embryos show increased cell death as assessed by TUNEL staining. The onset of this apoptosis appears several hours after development arrests.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference

Diap19 is an enhancer of abnormal cell death phenotype of grimGMR.PC

Diap19 is an enhancer of abnormal cell death phenotype of rprGMR.PW

Phenotype Manifest In
Enhancer of
Statement
Reference

Diap19 is an enhancer of eye phenotype of hidGMR.PG/WGMR.PG

Diap19 is an enhancer of eye phenotype of grimGMR.PC

Diap19 is an enhancer of eye phenotype of rprGMR.PW

Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Fails to complement
Comments

Fails to complement other lethal th alleles for lethality.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer

Revertant.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Diap19
th9
Name Synonyms
Secondary FlyBase IDs
    References (1)