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General Information
Symbol
Dmel\Diap181.03
Species
D. melanogaster
Name
FlyBase ID
FBal0103510
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

G16038724A

Amino acid change:

C422Y | Diap1-PA; C422Y | Diap1-PB; C422Y | Diap1-PC; C422Y | Diap1-PD; C422Y | Diap1-PE; C422Y | Diap1-PF

Reported amino acid change:

C422Y

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. C422 falls in the RING domain.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: C422Y. C422 falls in the RING domain.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Embryos show increased cell death as assessed by TUNEL staining. Development proceeds further in development than do the loss of function alleles.

Embryos exhibit defects in cellularization.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference
Suppressor of
Statement
Reference
Phenotype Manifest In
Enhancer of
Statement
Reference

Diap181.03 is an enhancer of eye phenotype of grimGMR.PC

Diap181.03 is an enhancer of eye phenotype of rprGMR.PW

Suppressor of
Statement
Reference

Diap181.03 is a suppressor of eye phenotype of hidGMR.PG/WGMR.PG

Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

One of 6 th mutants isolated.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Diap181.03
th81.03
Name Synonyms
Secondary FlyBase IDs
    References (2)