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General Information
Symbol
Dmel\Diap1109.07
Species
D. melanogaster
Name
FlyBase ID
FBal0103518
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

G16039828A

Amino acid change:

W54term | Diap1-PA; W54term | Diap1-PB; W54term | Diap1-PC; W54term | Diap1-PD; W54term | Diap1-PE; W54term | Diap1-PF

Reported amino acid change:

W54term

Comment:

G to A nucleotide change at the second or third position of the wild type Trp codon leads to a nonsense mutation (exact site of mutation unspecified). The mutation was annotated at the second base of the codon.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

The premature stop codon is in the BIR1 domain.

Amino acid replacement: W54term.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Cells in homozygous embryos show typical features of apoptosis, such as DNA fragmentation. All cells in gastrulating mutant embryos become TUNEL-positive, in contrast to wild-type embryos, where apoptosis is not detectable during gastrulation.

Embryos show increased cell death as assessed by TUNEL staining. The onset of this apoptosis appears several hours after development arrests.

Embryos exhibit defects in cellularization.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference
Phenotype Manifest In
Enhancer of
Statement
Reference

Diap1109.07 is an enhancer of eye phenotype of hidGMR.PG/WGMR.PG

Diap1109.07 is an enhancer of eye phenotype of grimGMR.PC

Diap1109.07 is an enhancer of eye phenotype of rprGMR.PW

Additional Comments
Genetic Interactions
Statement
Reference

Expression of armD88A.Scer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4mat.αTub67C.T:Hsim\VP16 slightly delays the execution of apoptosis in th109.07 embryos, but apoptosis is otherwise unimpaired in the double mutant embryos.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

One of 6 th mutants isolated.

Shows slightly weaker ability to enhance rpr-killing than a deletion of the gene.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (5)
Reported As
Symbol Synonym
Diap1109.07
th109.07
Name Synonyms
Secondary FlyBase IDs
    References (4)