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General Information
Symbol
Dmel\spenAH393
Species
D. melanogaster
Name
FlyBase ID
FBal0103540
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

In mutant embryos, the midline glia cells (MGCs) are reduced in number and do not ensheathe the commissures, as seen in wild-type, leading to reduced separation between the anterior and posterior commissure bundles. At stage 12 MGCs appear normal, at stage 13 a migration defects is apparent and by stage 17 fewer (1-2 per segment) MGCs persist than seen in wild-type (about 3 per segment). Mutants also have collapsed commissures, reduced separation between the two longitudinal branches, and gaps and inappropriate crossing of the midline by the longitudinal axons producing a fragmented and disorganised longitudinal axonal array. spenAH393/+ embryos show central nervous system defects in about 4% of embryos.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Suppressor of
Statement
Reference

spen[+]/spenAH393 is a suppressor of visible | dominant phenotype of N55e11

Other
Statement
Reference
Phenotype Manifest In
Enhanced by
Statement
Reference
Enhancer of
Statement
Reference
NOT Enhancer of
Statement
Reference

spenAH393 is a non-enhancer of phenotype of Ras85DV12.sev

Suppressor of
Statement
Reference

spen[+]/spenAH393 is a suppressor of wing phenotype of N55e11

NOT Suppressor of
Statement
Reference

spenAH393 is a non-suppressor of phenotype of Ras85DV12.sev

Additional Comments
Genetic Interactions
Statement
Reference

Dominantly suppresses the Df(1)N-54l9/+ and N55e11/+ wing nicking phenotypes.

when pntunspecified/+ is added to spenAH393 heterozygotes, about 25% of embryos exhibit axonal defects. The predominant phenotype is reduced separation between the two longitudinal axon pathways and an occasional inappropriate crossing of the midline.

Effect on aopS2382 and Ras85DN17.sev is mild. Effect on aopACT.GMR is moderate. Effect on aopACT.sev is strong. Lethal in combination with phl12 at 18oC.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Fails to complement
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

"X ray" was stated as tentative. "ethyl methanesulfonate" was stated as tentative.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (4)