Growth of the wing and wing margin formation can be restored in apmd544/apUGO35 flies expressing fngEP3082 under the control of Scer\GAL4ap-md544. Both surfaces of the wing differentiate ventral structures; the anterior wing margin and alula differentiate ventral bristles on both surfaces and the pattern of vein corrugation is ventral. Co-expression of fngEP3082 and DrScer\UAS.cIa under the control of Scer\GAL4ap-md544 in apmd544/apUGO35 flies results in dorsal differentiation in bristles of the dorsal anterior wing margin.
Expression of fngEP3082 under the control of Scer\GAL4ap-md544 rescues the phenotype of apmd544/apUGO35 flies. Patches of ectopic wing margin form and can be associated with outgrowth of the wing. Cells appear to violate the dorsoventral boundary in apmd544/apUGO35 wing discs which are also expressing fngEP3082 under the control of Scer\GAL4ap-md544. Expression of both SerScer\UAS.cSa and fngEP3082 under the control of Scer\GAL4ap-md544 in apmd544/apUGO35 flies results in well-developed wings which differentiate ventral features on both surfaces; the wing margin, veins and sense organs on the topologically dorsal surface have exclusively ventral identity.