FB2025_01 , released February 20, 2025
Allele: Dmel\crbIntraY10A.E16A.UAS.Tag:MYC
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General Information
Symbol
Dmel\crbIntraY10A.E16A.UAS.Tag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0103862
Feature type
allele
Associated gene
Dmel\crb
Associated Insertion(s)
Carried in Construct
P{UAS-crb.IntraY10A.E16A}
Also Known As
UAS-crbMyc-PBM
Key Links
Transgenic product class
inframe_deletion
(Klebes and Knust, 2000)
missense_variant
(Klebes and Knust, 2000)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Klebes and Knust, 2000)
missense_variant
(Klebes and Knust, 2000)
Mutagen
in vitro construct
(Klebes and Knust, 2000)
Progenitor genotype
crbintra.UAS.Tag:MYC
(Klebes and Knust, 2000)
Carried in construct
P{UAS-crb.IntraY10A.E16A}
Cytology
Description

Amino acid replacement: E16A. Amino acid replacement: Y10A.

(Klebes and Knust, 2000)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
crb
Tagged with
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  neurodegenerative disease
      modeled by Hsap\APPAβ42.UAS.cUa
      (Steffensmeier et al., 2013)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The expression of crbIntraY10A.E16A.UAS.Tag:MYC under the control of Scer\GAL4GMR.long leads to a decrease in the ratio of pale vs yellow photoreceptor cells R8.

      (Pojer et al., 2021)

      Scer\GAL4rn-GAL4-5-mediated expression results in neoplastic wing disc overgrowth.

      (Andersen et al., 2015)

      When expression is driven in the eye by Scer\GAL4GMR.PF, adherens junctions do not form ectopically and cell polarity is normal within the photoreceptors.

      (Izaddoost et al., 2002)

      Over expression of crbIntraY10A.E16A.Scer\UAS.T:Hsap\MYC when driven by Scer\GAL4da.G32 produces embryos with an epidermis that develops as a multilayered tissue (unlike the single layered epithelium seen in wild-type embryos).

      (Klebes and Knust, 2000)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Co-expression of crbIntraY10A.E16A.Scer\UAS.T:Hsap\MYC rescues the adult eye neurodegeneration phenotype seen in animals expressing Hsap\APPAβ42.Scer\UAS.cUa under the control of Scer\GAL4GMR.PU. The increased cell death phenotype which is seen in the eye imaginal discs of animals expressing Hsap\APPAβ42.Scer\UAS.cUa under the control of Scer\GAL4GMR.PU is also significantly suppressed.

      (Steffensmeier et al., 2013)
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      crbIntraY10A.E16A.Scer\UAS.T:Hsap\MYC
      crbIntraY10A.E16A.UAS.Tag:MYC
      Name Synonyms
      Secondary FlyBase IDs
        References (7)