FlyBase Allele Report: Dmel\cic[1]

General Information

Symbol

Dmel\cic¹

Species

D. melanogaster

Name

FlyBase ID

FBal0103875

Feature type

allele

Associated gene

Dmel\cic

Associated Insertion(s)

H{}cic¹

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - genetic evidence

Mutagen

hobo activity

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Jimenez et al., 2000)

Mutagen

hobo activity

(Roch et al., 2002, Jimenez et al., 2000)

Progenitor genotype

Associated Insertion(s)

H{}cic¹

Cytology

Description

the H{}cic¹ insertion within the first exon of cic.

(Roch et al., 2002)

Insertion of a 1.5kb hobo in the 5' untranslated region.

(Jimenez et al., 2000)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3R:20,293,266..20,293,448 [+]

(Roch et al., 2002, Jimenez et al., 2000)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

abdominal segment

(de las Heras and Casanova, 2006)

embryonic/first instar larval cuticle

(Astigarraga et al., 2007, de las Heras and Casanova, 2006)

embryonic/first instar larval cuticle (with cic^fet-U6)

(Goff et al., 2001)

embryonic/first instar larval cuticle (with cic^Q474X)

(Forés et al., 2015)

embryonic/first instar larval cuticle (with cic^Q474X), with cic^L.Tag:HA

(Forés et al., 2015)

embryonic/first instar larval cuticle (with cic^Q474X), with cic^L-N2.Tag:HA

(Forés et al., 2015)

embryonic/first instar larval cuticle (with cic^Q474X), with cic^{LYLmut.Tag:HA}

(Forés et al., 2015)

embryonic/first instar larval cuticle (with cic^Q474X), with cic^Smut.Tag:HA

(Forés et al., 2015)

embryonic/first instar larval cuticle (with cic^Q474X), with cic^ΔN2.Tag:HA

(Forés et al., 2015)

embryonic abdominal segment

(Jimenez et al., 2000)

ventral denticle belt

(Jimenez et al., 2000)

Detailed Description

Statement

Reference

Embryos produced by cic¹/cic^Q474X, cic¹/cic⁴ or cic¹/Df(3R)ED6027 females exhibit severe defects including loss of thoracic and abdominal regions.

(Forés et al., 2017)

Cuticles of homozygous cic¹ mutant embryos display strongly suppressed trunk and abdomen.

(Astigarraga et al., 2007)

Embryos from cic¹/+ mothers make normal cuticles with no sign of segmentation defects, but those from cic¹ homozygous mothers show evidence of severe segmentation defects.

(de las Heras and Casanova, 2006)

Homozygous mutants and cic¹/cic^D49 have a terminal phenotype.

(Roch et al., 2002)

cic¹/cic^fet-U6 females produce embryos with a tor gain-of-function phenotype.

(Goff et al., 2001)

Homozygous females produce embryos that form head and tail structures but lack most of the segmented trunk. More than 80% of embryos retain only 1-3 partial abdominal denticle belts at 25^oC and the rest of the embryos show no signs of abdominal segmentation. Embryos derived from hemizygous females show a slightly more severe phenotype than those derived from homozygous females.

(Jimenez et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

ca¹, cic¹ has wild-type phenotype

(Ma et al., 2004)

bwk^Δ4, cic¹ has wild-type phenotype

(Roch et al., 2002)

bwk^Δ11, cic¹ has lethal - all die during embryonic stage phenotype

(Roch et al., 2002)

bwk^Δ14, cic¹ has lethal - all die during embryonic stage phenotype

(Roch et al., 2002)

bwk^Δ81, cic¹ has lethal phenotype

(Roch et al., 2002)

bwk^Δ81, cic¹ has lethal - all die during embryonic stage phenotype

(Roch et al., 2002)

Phenotype Manifest In

Enhanced by

Statement

Reference

cic¹ has embryonic/first instar larval cuticle phenotype, enhanceable by trk[+]/tor[+]/trk¹/tor^11D

(de las Heras and Casanova, 2006)

Suppressed by

Statement

Reference

cic¹/cic[+], tor^11D, trk¹ has embryonic segment | maternal effect phenotype, suppressible | maternal effect | partially by Stat92E[+]/Stat92E⁰⁶³⁴⁶

(de las Heras and Casanova, 2006)

cic¹/cic[+], tor^11D, trk[+]/trk¹ has embryonic/first instar larval cuticle | maternal effect phenotype, suppressible | maternal effect | partially by Stat92E[+]/Stat92E⁰⁶³⁴⁶

(de las Heras and Casanova, 2006)

NOT suppressed by

Statement

Reference

cic¹ has phenotype, non-suppressible by Dsor1¹

(Jimenez et al., 2000)

cic¹ has phenotype, non-suppressible by Raf^LE78

(Jimenez et al., 2000)

cic¹ has phenotype, non-suppressible by tor^rv66

(Jimenez et al., 2000)

Enhancer of

Statement

Reference

cic¹/cic[+] is an enhancer | maternal effect of embryonic segment | maternal effect phenotype of tor^11D, trk[+]/trk¹

(de las Heras and Casanova, 2006)

cic¹/cic[+] is an enhancer | maternal effect of embryonic/first instar larval cuticle | maternal effect phenotype of tor^11D, trk[+]/trk¹

(de las Heras and Casanova, 2006)

NOT Enhancer of

Statement

Reference

cic¹ is a non-enhancer of embryonic abdominal segment 8 | maternal effect phenotype of psq^rum

(Grillo et al., 2011)

cic¹ is a non-enhancer of filzkorper | maternal effect phenotype of psq^rum

(Grillo et al., 2011)

NOT Suppressor of

Statement

Reference

cic¹ is a non-suppressor of embryonic abdominal segment 8 | maternal effect phenotype of psq^rum

(Grillo et al., 2011)

cic¹ is a non-suppressor of filzkorper | maternal effect phenotype of psq^rum

(Grillo et al., 2011)

Other

Statement

Reference

Tl^r4, bcd⁷, cic¹, osk⁶, tsl¹ has embryo phenotype

(Soluri et al., 2020)

bwk^Δ4, cic¹ has wing vein | ectopic phenotype

(Roch et al., 2002)

Additional Comments

Genetic Interactions

Statement

Reference

Embryos derived from homozygous psq^rum cic¹ double mutant females show terminal defects resembling the psq^rum single mutant phenotype.

(Grillo et al., 2011)

The segmentation defects seen in embryos from cic¹ homozygous are enhanced if the mothers are also trk¹/+; tor^11D/+.

(de las Heras and Casanova, 2006)

cic¹ combined with bwk^Δ4 and bwk⁰⁸⁴⁸² produces wild-type animals, with bwk^Δ14, bwk^Δ81 and bwk^Δ11 produces animals with a terminal phenotype.

(Roch et al., 2002)

The phenotype of embryos derived from homozygous females is not altered if the females are also homozygous for tor^rv66 or carry germline clones of phl^LE78 or Dsor1¹.

(Jimenez et al., 2000)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

cic^D49

(Roch et al., 2002)

cic^Δ14

(Jimenez et al., 2000)

Rescued by

cic¹ is rescued by cic^Tag:HA

(Astigarraga et al., 2007)

cic¹ is rescued by cic^mini.Tag:HA

(Astigarraga et al., 2007)

cic¹ is rescued by cic^ΔC2.Tag:HA

(Astigarraga et al., 2007)

cic¹ is rescued by cic^+tJa

(Jimenez et al., 2000)

Partially rescued by

cic^Q474X/cic¹ is partially rescued by cic^Smut.Tag:HA

(Forés et al., 2015)

cic^Q474X/cic¹ is partially rescued by cic^L-N2.Tag:HA

(Forés et al., 2015)

cic¹ is partially rescued by cic^ΔC1.Tag:HA

(Astigarraga et al., 2007)

Not rescued by

cic^Q474X/cic¹ is not rescued by cic^{LYLmut.Tag:HA}

(Forés et al., 2015)

cic^Q474X/cic¹ is not rescued by cic^L.Tag:HA

(Forés et al., 2015)

cic^Q474X/cic¹ is not rescued by cic^ΔN2.Tag:HA

(Forés et al., 2015)

cic¹ is not rescued by cic^ΔHMG.Tag:HA

(Astigarraga et al., 2007)

cic¹ is not rescued by cic^{miniNLS.Tag:HA,Tag:NLS(SV40-largeT)}

(Astigarraga et al., 2007)

Comments

Maternal expression of cic^T:Ivir\HA1 rescues the embryonic cuticle phenotype of homozygous cic¹ mutants.

Maternal expression of cic^{mini.T:Ivir\HA1} rescues the embryonic cuticle phenotype of homozygous cic¹ mutants.

Maternal expression of cic^{ΔC1.T:Ivir\HA1} only partially rescues the embryonic cuticle phenotype of homozygous cic¹ mutants.

Expression of cic^{ΔHMG.T:Ivir\HA1} fails to rescue cic¹.

cic^{miniNLS.T:Ivir\HA1,T:SV40\nls2} is unable to rescue cic¹.

A single copy of weak cic^{ΔC2.T:Ivir\HA1} insertions rescues the cic¹ mutation to adulthood.

(Astigarraga et al., 2007)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Complements: bwk⁰⁸⁴⁸².

(Jimenez et al., 2000)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

capicua¹

(Martinho et al., 2004)

cic¹

(Keenan et al., 2020, Soluri et al., 2020, Papagianni et al., 2018, Forés et al., 2017, Forés et al., 2015, Esteves et al., 2014, Chen et al., 2012, Grimm et al., 2012, Ajuria et al., 2011, Garcia and Stathopoulos, 2011, Grillo et al., 2011, Helman et al., 2011, Löhr et al., 2009, Astigarraga et al., 2007, de las Heras and Casanova, 2006)

Name Synonyms

Secondary FlyBase IDs

References (20)

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