The induction of Su(H)del47
somatic clones leads to a severe increase in the adult posterior midgut mitotic index in females only, as compared to controls.
homozygous lateral antennal lobe neuroblast clones, induced at the newly-hatched larval stage, have fewer antennal mechanosensory and motor center neurite projection tracts and 3 times the number of later-born uniglomerular lateral antennal lobe projection neurons in the adult; clones have similar total numbers of cells to controls by adulthood and clone size and cell division (PH3 staining) are unaffected at 30 and 70 hours after larval hatching.
Multilayering of intestinal stem cells and enteroendocrine cells is seen in homozygous clones in the adult intestine.
mutant clones generated in type II neuroblasts are smaller than control clones. In contrast, clones that originate in type I clones are similar in size to controls.
Homozygous clones in the outer proliferation center neuroepithelium (induced at late-first or early-second instar and analysed at late-third instar) adopt an irregular cell morphology rather than the normal columnar epithelial cell morphology in 78.6% of cases.
Homozygous intestinal stem cell (ISC) clones show an overproliferation of small ISC-like cells.
clones in the wing disc are relatively small and scattered over the disc, with very rugged edges. They are associated with a large number of dead cells in the basal side.
Follicle stem cell clones homozygous for Su(H)del47
persist in the ovariole approximately as well as control clones over a 14 day period.
Homozygous intestinal stem cell (ISC) clones in the adult midgut form tumours.
The dorsal/ventral boundary is established correctly in Su(H)del47
mutant wing imaginal discs.
mutant germline stem cells are maintained in the niche similarly to wild-type control clones. Su(H)del47
clones of cap cells and escort stem cells result in a reduction of region 1 of the germaria.
mutant cells do not enter the second mitotic wave.
Mitotic clones of cells carrying Su(H)del47
rarely contribute to the presumptive anterior dorsal-ventral region of the eye disc.
R8 photoreceptor differentiation is normal or early in Su(H)del47
single mutant clones. In addition, many ectopic R8 photoreceptors differentiate in these clones.
Mutant wing discs exhibit a lack of neural differentiation. The proneural clusters appear to arrest their development during an early phase of sensory organ precursor development. When mutant clones are made in the wing disc, a delay in the development of the pDC sensory organ precursors is seen.
Homozyogous somatic clones in the adult eye are neurogenic. Mutant cells also differentiate prematurely.
Large homozygous mutant clones that presumably include the polar cell precursors lead to fusions between adjacent egg chambers. Mutant epithelial follicle cells continue to divide after stage 6. When mutant clones include the follicle cells at the posterior of the egg chamber, the germinal vesicle often fails to migrate and remains at the posterior pole.