|Feature type||allele||Associated gene||Dmel\Pten|
What does this section display?
This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).
What does this section not display?
This section does not currently display links that were removed or gene model changes.
Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
|All updates||Click here to see a list of all updates to this record from FB2010_08 and on.|
|Nature of the Allele|
|Mutations Mapped to the Genome|
|Associated Sequence Data|
|Nature of the lesion|
|Phenotype Manifest In|
wing & cell | somatic clone
Homozygous clones in the eye disc result in strong overgrowth of the eye.
Hemizygotes die as late embryos or early first instar larvae. Homozygous mutant clones in the eye bulge out from the eye surface. Ommatidia sometimes fuse interommatidial bristles are abnormal, particularly (but not exclusively) in the dorsal half of the eye. Mutant clones typically contain at least twice as many ommatidia as their wild type twin spots. The largest clones can form a hyperplastic tumor-like overgrowth, though this phenotype is less severe than for tumor suppressor mutations. Within each ommatidium cell type specification seems normal. Cell bodies of mutant photoreceptors are enlarged compared to wild type neighbors, and the rhabdomeres are misshapen. The cell size and rhabdomeric phenotypes are cell autonomous. Homozygous mutant clones in the wing reveal an increase in cell size. Wing hairs are occasionally duplicated and crossvein formation is abnormal. Occasional extra wing vein material develops. Longitudinal veins are rarely affected.
Df(2L)flp170B/Pten3 has lethal | late third instar larval stage phenotype, suppressible | partially by Akt1[+]/Akt11
Df(2L)flp170B/Pten3 has lethal | late third instar larval stage phenotype, suppressible | partially by Scer\GAL4arm.PS/gigScer\UAS.cGa/Tsc1Scer\UAS.cGa
Df(2L)flp170B/Pten3 has lethal | late third instar larval stage phenotype, suppressible | partially by wdbGS9548/Scer\GAL4arm.PS
|Phenotype Manifest In|
77% of Pten/Df(2L)flp170B animals survive to adulthood in the presence of Akt1/+. Expression of Tsc1[Scer\UAS.cGa] and gig[Scer\UAS.cGa] under the control of Scer\GAL4[arm.PS] rescues lethality in 40% of Pten/Df(2L)flp170B animals. Expression of wdb[GS9548] under the control of Scer\GAL4[arm.PS] rescues lethality in 52% of Pten/Df(2L)flp170B animals.
|Complementation & Rescue Data|
|Fails to complement|
|Stocks ( 0 )|
|Notes on Origin|
|External Crossreferences & Linkouts|
|Synonyms & Secondary IDs ( 3 )|
|Secondary FlyBase IDs|
|References ( 6 )|