FlyBase Allele Report: Hsap\HSPA1L[UAS.cWa]

General Information

Symbol

Hsap\HSPA1L^UAS.cWa

Species

H. sapiens

Name

Saccharomyces cerevisiae UAS construct a of Warrick

FlyBase ID

FBal0104117

Feature type

allele

Associated gene

Hsap\HSPA1L

Associated Insertion(s)

Carried in Construct

P{UAS-Hsap\HSPA1L.W}

Also Known As

UAS-HspA1L, UAS-hsp70, UAS-hspA1, Hsp70

Key Links

Transgenic product class

cDNA

(Warrick et al., 1999)

wild_type

(Warrick et al., 1999)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Warrick et al., 1999)

wild_type

(Warrick et al., 1999)

Mutagen

in vitro construct

(Warrick et al., 1999)

Progenitor genotype

Carried in construct

P{UAS-Hsap\HSPA1L.W}

Cytology

Description

UASt regulatory sequences drive expression of an Hsap\HSPA1L cDNA.

(Warrick et al., 1999)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Hsap\HSPA1L

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates neurodegenerative disease

modeled by Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}

(Wong et al., 2008, Huen and Chan, 2005, Bonini, 2002, Chan et al., 2000)

modeled by Zzzz\CAG^{250.UAS.DsRed2}

(Shieh and Bonini, 2011)

modeled by Zzzz\CAG^{127Q.UAS.Tag:HA}

(Ghosh and Feany, 2004)

modeled by Hsap\HTT^GMR.Q120

(Chan et al., 2000)

modeled by Hsap\HTT^Q93.ex1.UAS

(Liévens et al., 2008)

ameliorates Parkinson's disease

modeled by Hsap\SNCA^UAS.cFa

(Auluck et al., 2002)

ameliorates prion disease

modeled by Maur\Prp^UAS.cFa

(Fernandez-Funez et al., 2009)

ameliorates autosomal dominant cerebellar ataxia

modeled by Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}

(Ghosh and Feany, 2004)

modeled by Hsap\ATXN1^82.UAS

(Ghosh and Feany, 2004)

ameliorates amyotrophic lateral sclerosis

modeled by Hsap\TARDBP^{A315T.UAS.YFP}

(Estes et al., 2011)

modeled by Hsap\TARDBP^UAS.YFP.cEa

(Estes et al., 2011)

ameliorates Machado-Joseph disease

modeled by Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}

(Vinatier et al., 2015, Cushman-Nick et al., 2013, Warrick et al., 1999)

modeled by Hsap\ATXN3^{fl.Q78.UAS.Tag:HA}

(Cushman-Nick et al., 2013)

modeled by Hsap\ATXN3^{fl.Q84.UAS.Tag:MYC}

(Yeh et al., 2018)

ameliorates glycoproteinosis

modeled by Trpml¹

(Venkatachalam et al., 2008)

ameliorates frontotemporal dementia

modeled by Hsap\FUS^{UAS.cMa.Tag:HA}

(Miguel et al., 2012)

exacerbates mucopolysaccharidosis type IIIA

modeled by Sgsh^GD1578

(Webber et al., 2018)

ameliorates Alzheimer's disease 1

modeled by Hsap\APP^2xAPP.SP.UAS

(Martín-Peña et al., 2018)

ameliorates Huntington's disease

modeled by Hsap\HTT^{Q97.ex1.UAS.cAa}

(Ast et al., 2018)

modeled by Hsap\HTT^Q93.ex1.UAS

(McLear et al., 2008)

modeled by Hsap\HTT^{Q138.UAS.mRFP1}

(Swinter et al., 2023)

ameliorates Parkinson's disease 1

modeled by Hsap\SNCA^UAS.cFa

(Krzystek et al., 2021)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4^Toll-6-D42

(Santana et al., 2020)

presynaptic active zone | decreased number | third instar larval stage, with Scer\GAL4^Toll-6-D42

(Santana et al., 2020)

rhabdomere, with Scer\GAL4^GMR.PF

(Warrick et al., 1999)

Detailed Description

Statement

Reference

Adults expressing Hsap\HSPA1L^UAS.cWa under the control of Scer\GAL4^elav.PLu do not exhibit climbing defects compared to controls.

(Webber et al., 2018)

Flies expressing Hsap\HSPA1L^Scer\UAS.cWa under the control of Scer\GAL4^GMR.PU do not exhibit any obvious eye phenotypes.

(Fernandez-Funez et al., 2016)

Expression of Hsap\HSPA1L^Scer\UAS.cWa under the control of Scer\GAL4^GMR.PF has no effect on eye pigmentation.

(Estes et al., 2011)

Flies expressing Hsap\HSPA1L^Scer\UAS.cWa under the control of Scer\GAL4^da.PU do not exhibit climbing defects.

(Shieh and Bonini, 2011)

Flies expressing Hsap\HSPA1L^Scer\UAS.cWa under the control of Scer\GAL4^Mhc.PW show normal wing positions.

(Chartier et al., 2006)

Expression of Hsap\HSPA1L^Scer\UAS.cWa under the control of Scer\GAL4^GMR.PU does not cause degeneration or pigment loss in the adult eye.

(Huen and Chan, 2005)

Co-expression of Hsap\HSPA1L^Scer\UAS.cWa partially suppresses the mutant eye phenotype caused by expression of Hsap\HSPA1L^{K71E.Scer\UAS} under the control of Scer\GAL4^GMR.PF.

(Warrick et al., 2005)

The reduction in electroretinogram (ERG) amplitude seen in flies exposed to constant light is not significantly affected by expression of Hsap\HSPA1L^Scer\UAS.cWa under the control of Scer\GAL4^GMR.PF.

(Lee and Montell, 2004)

Expression of Hsap\HSPA1L^Scer\UAS.cWa under the control of Scer\GAL4^GMR.PF does not result in a rough eye phenotype.

(Shulman and Feany, 2003)

The eye appears grossly normal in flies expressing Hsap\HSPA1L^Scer\UAS.cWa under the control of Scer\GAL4^GMR.PF, although there are abnormalities in nuclear position and photoreceptor rhabdomere morphology.

(Warrick et al., 1999)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Hsap\HSPA1L^UAS.cWa, Scer\GAL4^GMR.PF, Scer\GAL80^ts.αTub84B has abnormal neuroanatomy | progressive | heat sensitive phenotype, suppressible by Hsap\HSPA1L^UAS.cWa, Scer\GAL4^GMR.PF, Scer\GAL80^ts.αTub84B

(Wong et al., 2008)

Enhancer of

Statement

Reference

Hsap\HSPA1L^UAS.cWa, Scer\GAL4^elav.PLu is an enhancer of abnormal locomotor behavior | adult stage | progressive phenotype of Scer\GAL4^elav.PLu, Sgsh^GD1578

(Webber et al., 2018)

NOT Enhancer of

Statement

Reference

Hsap\HSPA1L^UAS.cWa, Scer\GAL4^GMR.PF is a non-enhancer of visible phenotype of Hsap\MAPT^V337M.UAS, Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Suppressor of

Statement

Reference

Hsap\HSPA1L^UAS.cWa, Scer\GAL4^ey-OK107 is a suppressor | partially of increased cell death | adult stage phenotype of Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^ey-OK107

(Fernandez-Funez et al., 2016)

Hsap\HSPA1L^UAS.cWa is a suppressor of visible | adult stage phenotype of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2016)

Hsap\HSPA1L^UAS.cWa, Scer\GAL4^GMR.PU is a suppressor | partially of visible | adult stage | progressive phenotype of Hsap\ATXN3^{fl.Q78.UAS.Tag:MYC}, Scer\GAL4^GMR.PU

(Vinatier et al., 2015)

Hsap\HSPA1L^UAS.cWa, Scer\GAL4^GMR.PU is a suppressor | partially of abnormal eye color | progressive phenotype of Hsap\ATXN3^{fl.Q78.UAS.Tag:MYC}, Scer\GAL4^GMR.PU

(Vinatier et al., 2015)

Hsap\HSPA1L^UAS.cWa, Scer\GAL4^ey-OK107 is a suppressor | partially of abnormal neuroanatomy | adult stage phenotype of Nmnat^JF03337, Scer\GAL4^ey-OK107

(Rallis et al., 2013)

Scer\GAL4^ey-OK107/Hsap\HSPA1L^UAS.cWa is a suppressor of abnormal neuroanatomy | somatic clone | adult stage | progressive phenotype of bsk^flp147E

(Rallis et al., 2013)

Hsap\HSPA1L^UAS.cWa, Scer\GAL4^GMR.long is a suppressor of visible phenotype of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long

(Butler et al., 2012)

Hsap\HSPA1L^UAS.cWa, Scer\GAL4^GMR.PF is a suppressor of visible | heat sensitive phenotype of Hsap\FUS^{UAS.cMa.Tag:HA}, Scer\GAL4^GMR.PF

(Miguel et al., 2012)

Hsap\HSPA1L^UAS.cWa, Scer\GAL4^{elav.Switch.PO} is a suppressor | RU486 conditional of short lived | RU486 conditional phenotype of Hsap\FUS^{UAS.cMa.Tag:HA}, Scer\GAL4^{elav.Switch.PO}

(Miguel et al., 2012)

Hsap\HSPA1L^UAS.cWa, Scer\GAL4^GMR.PF is a suppressor | partially of visible | adult stage | heat sensitive phenotype of Hsap\TARDBP^UAS.YFP.cEa, Scer\GAL4^GMR.PF

(Estes et al., 2011)

Hsap\HSPA1L^UAS.cWa, Scer\GAL4^GMR.PF is a suppressor | partially of visible | adult stage phenotype of Hsap\TARDBP^{A315T.UAS.YFP}, Scer\GAL4^GMR.PF

(Estes et al., 2011)

Hsap\HSPA1L^UAS.cWa, Scer\GAL4^GMR.PU is a suppressor | partially of visible phenotype of Hsap\ATXN3^{CAA.tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU

(Shieh and Bonini, 2011)

Hsap\HSPA1L^UAS.cWa, Scer\GAL4^Act.PU is a suppressor | partially of abnormal locomotor behavior | adult stage | progressive phenotype of Maur\Prp^UAS.cFa, Scer\GAL4^Act.PU

(Fernandez-Funez et al., 2009)

Hsap\HSPA1L^UAS.cWa, Scer\GAL4^Eaat1.PR is a suppressor | partially of short lived phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^Eaat1.PR

(Liévens et al., 2008)

Hsap\HSPA1L^UAS.cWa, Scer\GAL4^repo.PU is a suppressor | partially of short lived phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^repo.PU

(Liévens et al., 2008)

Hsap\HSPA1L^UAS.cWa, Scer\GAL4^elav-C155 is a suppressor of decreased cell number phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155

(Liévens et al., 2008)

Hsap\HSPA1L^UAS.cWa, Scer\GAL4^elav-C155 is a suppressor of short lived phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155

(Liévens et al., 2008)

Hsap\HSPA1L^UAS.cWa, Scer\GAL4^elav-C155 is a suppressor of abnormal neuroanatomy | adult stage phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155

(Liévens et al., 2008)

Hsap\HSPA1L^UAS.cWa, Scer\GAL4^elav-C155 is a suppressor of abnormal locomotor behavior | adult stage phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155

(Liévens et al., 2008)

Hsap\HSPA1L^UAS.cWa, Scer\GAL4^GMR.PU is a suppressor of visible phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU

(Liévens et al., 2008)

Hsap\HSPA1L^UAS.cWa, Scer\GAL4^GMR.PU is a suppressor of abnormal eye color | progressive phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU

(Liévens et al., 2008)

Scer\GAL4^Act5C.PI/Hsap\HSPA1L^UAS.cWa is a suppressor of lethal phenotype of Trpml¹

(Venkatachalam et al., 2008)

Scer\GAL4^elav-C155/Hsap\HSPA1L^UAS.cWa is a suppressor of lethal phenotype of Trpml¹

(Venkatachalam et al., 2008)

Scer\GAL4^Act5C.PI/Hsap\HSPA1L^UAS.cWa is a suppressor of abnormal locomotor behavior | adult stage phenotype of Trpml¹

(Venkatachalam et al., 2008)

Scer\GAL4^elav-C155/Hsap\HSPA1L^UAS.cWa is a suppressor of abnormal locomotor behavior | adult stage phenotype of Trpml¹

(Venkatachalam et al., 2008)

Hsap\HSPA1L^UAS.cWa, Scer\GAL4^GMR.PF, Scer\GAL80^ts.αTub84B is a suppressor of abnormal neuroanatomy | progressive | heat sensitive phenotype of Hsap\HSPA1L^UAS.cWa, Scer\GAL4^GMR.PF, Scer\GAL80^ts.αTub84B

(Wong et al., 2008)

Hsap\HSPA1L^UAS.cWa, Scer\GAL4^Mhc.PW is a suppressor of visible phenotype of Hsap\PABPN1^17ala.UAS, Scer\GAL4^Mhc.PW

(Chartier et al., 2006)

Hsap\HSPA1L^UAS.cWa, Scer\GAL4^Ddc.PL is a suppressor of abnormal neuroanatomy phenotype of Hsap\SNCA^UAS.cFa, Scer\GAL4^Ddc.PL

(Auluck et al., 2002)

Hsap\HSPA1L^UAS.cWa/DnaJ-1^UAS.Tag:FLAG, Scer\GAL4^GMR.PF is a suppressor of visible phenotype of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF

(Bonini, 2002)

Hsap\HSPA1L^UAS.cWa, Scer\GAL4^GMR.PF is a suppressor of visible phenotype of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF

(Bonini, 2002, Warrick et al., 1999)

Scer\GAL4^elav-C155/Hsap\HSPA1L^UAS.cWa is a suppressor of abnormal neuroanatomy | progressive phenotype of Hsap\HTT^GMR.Q120

(Chan et al., 2000)

Hsap\HSPA1L^UAS.cWa/DnaJ-1^UAS.Tag:FLAG, Scer\GAL4^elav-C155 is a suppressor of lethal phenotype of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^elav-C155

(Chan et al., 2000)

Scer\GAL4^GMR.PU, Hsap\HSPA1L^UAS.cWa/DnaJ-1^UAS.Tag:FLAG is a suppressor of abnormal neuroanatomy phenotype of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU

(Chan et al., 2000)

NOT Suppressor of

Statement

Reference

Hsap\HSPA1L^UAS.cWa, Scer\GAL4^GMR.PU is a non-suppressor of visible | adult stage phenotype of Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2016)

Hsap\HSPA1L^UAS.cWa, Scer\GAL4^GMR.PU is a non-suppressor of increased cell death | adult stage phenotype of Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2016)

Hsap\HSPA1L^UAS.cWa, Scer\GAL4^GMR.PU is a non-suppressor of abnormal size | adult stage phenotype of Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2016)

Hsap\HSPA1L^UAS.cWa, Scer\GAL4^GMR.PU is a non-suppressor of increased cell death | larval stage phenotype of Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2016)

Hsap\HSPA1L^UAS.cWa, Scer\GAL4^elav.PU is a non-suppressor of abnormal locomotor behavior | progressive phenotype of Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^elav.PU

(Fernandez-Funez et al., 2016)

Hsap\HSPA1L^UAS.cWa, Scer\GAL4^elav.PU is a non-suppressor of short lived phenotype of Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^elav.PU

(Fernandez-Funez et al., 2016)

Scer\GAL4^repo/Hsap\HSPA1L^UAS.cWa is a non-suppressor of lethal phenotype of Trpml¹

(Venkatachalam et al., 2008)

Scer\GAL4^Cg.PA/Hsap\HSPA1L^UAS.cWa is a non-suppressor of lethal phenotype of Trpml¹

(Venkatachalam et al., 2008)

Scer\GAL4^c754/Hsap\HSPA1L^UAS.cWa is a non-suppressor of lethal phenotype of Trpml¹

(Venkatachalam et al., 2008)

Hsap\HSPA1L^UAS.cWa, Scer\GAL4^GMR.PF is a non-suppressor of visible phenotype of Hsap\MAPT^V337M.UAS, Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\HSPA1L^UAS.cWa, Scer\GAL4^GMR.PF is a non-suppressor of increased cell death | temperature conditional phenotype of Hsap\AR^{Q112.UAS.Tag:HA}, Scer\GAL4^GMR.PF, Uba2^C175S.UAS

(Chan et al., 2002)

Hsap\HSPA1L^UAS.cWa, Scer\GAL4^unspecified is a non-suppressor of visible phenotype of Scer\GAL4^unspecified, ey^UAS.cHa

(Warrick et al., 1999)

Hsap\HSPA1L^UAS.cWa, Scer\GAL4^unspecified is a non-suppressor of visible phenotype of Rnor\Map2^UAS.cAa, Scer\GAL4^unspecified

(Warrick et al., 1999)

Other

Statement

Reference

Hsap\APP^2xAPP.SP.UAS, Hsap\HSPA1L^UAS.cWa, Scer\GAL4^ey-OK107 has abnormal neuroanatomy | adult stage phenotype

(Fernandez-Funez et al., 2016)

Hsap\APP^2xAPP.SP.UAS, Hsap\HSPA1L^UAS.cWa, Scer\GAL4^ey-OK107 has abnormal size | adult stage phenotype

(Fernandez-Funez et al., 2016)

Phenotype Manifest In

Suppressed by

Statement

Reference

Hsap\HSPA1L^UAS.cWa, Scer\GAL4^GMR.PF, Scer\GAL80^ts.αTub84B has eye | progressive | heat sensitive phenotype, suppressible by Hsap\HSPA1L^UAS.cWa, Scer\GAL4^GMR.PF, Scer\GAL80^ts.αTub84B

(Wong et al., 2008)

Enhancer of

Statement

Reference

Scer\GAL4^GMR.PF, Prosβ6^1.UAS/Hsap\HSPA1L^UAS.cWa is an enhancer of eye phenotype of Hsap\AR^{Q112.UAS.Tag:HA}, Scer\GAL4^GMR.PF

(Chan et al., 2002)

NOT Enhancer of

Statement

Reference

Hsap\HSPA1L^UAS.cWa, Scer\GAL4^GMR.PF is a non-enhancer of eye phenotype of Hsap\MAPT^V337M.UAS, Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Suppressor of

Statement

Reference

Hsap\HSPA1L^UAS.cWa, Scer\GAL4^Appl.G1a is a suppressor of mitochondrion | larval stage phenotype of Hsap\HTT^{Q138.UAS.mRFP1}, Scer\GAL4^Appl.G1a

(Swinter et al., 2023)

Hsap\HSPA1L^UAS.cWa, Scer\GAL4^Appl.G1a is a suppressor of larval segmental nerve phenotype of Hsap\HTT^{Q138.UAS.mRFP1}, Scer\GAL4^Appl.G1a

(Swinter et al., 2023)

Hsap\HSPA1L^UAS.cWa, Scer\GAL4^Appl.G1a is a suppressor of axon | larval stage phenotype of Hsap\HTT^{Q138.UAS.mRFP1}, Scer\GAL4^Appl.G1a

(Swinter et al., 2023)

Hsap\HSPA1L^UAS.cWa, Scer\GAL4^ey-OK107 is a suppressor | partially of Kenyon cell phenotype of Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^ey-OK107

(Fernandez-Funez et al., 2016)

Hsap\HSPA1L^UAS.cWa, Scer\GAL4^GMR.PU is a suppressor | partially of eye | progressive phenotype of Hsap\ATXN3^{fl.Q78.UAS.Tag:MYC}, Scer\GAL4^GMR.PU

(Vinatier et al., 2015)

Hsap\HSPA1L^UAS.cWa, Scer\GAL4^ey-OK107 is a suppressor | partially of alpha/beta Kenyon cell | adult stage phenotype of Nmnat^JF03337, Scer\GAL4^ey-OK107

(Rallis et al., 2013)

Scer\GAL4^ey-OK107/Hsap\HSPA1L^UAS.cWa is a suppressor of alpha/beta Kenyon cell phenotype of bsk^flp147E

(Rallis et al., 2013)

Scer\GAL4^ey-OK107/Hsap\HSPA1L^UAS.cWa is a suppressor of gamma Kenyon cell phenotype of bsk^flp147E

(Rallis et al., 2013)

Hsap\HSPA1L^UAS.cWa, Scer\GAL4^GMR.long is a suppressor of eye phenotype of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long

(Butler et al., 2012)

Hsap\HSPA1L^UAS.cWa, Scer\GAL4^GMR.PF is a suppressor of interommatidial bristle | heat sensitive phenotype of Hsap\FUS^{UAS.cMa.Tag:HA}, Scer\GAL4^GMR.PF

(Miguel et al., 2012)

Hsap\HSPA1L^UAS.cWa, Scer\GAL4^GMR.PF is a suppressor of eye | heat sensitive phenotype of Hsap\FUS^{UAS.cMa.Tag:HA}, Scer\GAL4^GMR.PF

(Miguel et al., 2012)

Hsap\HSPA1L^UAS.cWa, Scer\GAL4^GMR.PF is a suppressor | partially of eye | heat sensitive phenotype of Hsap\TARDBP^UAS.YFP.cEa, Scer\GAL4^GMR.PF

(Estes et al., 2011)

Hsap\HSPA1L^UAS.cWa, Scer\GAL4^GMR.PF is a suppressor | partially of eye | heat sensitive phenotype of Hsap\TARDBP^{A315T.UAS.YFP}, Scer\GAL4^GMR.PF

(Estes et al., 2011)

Hsap\HSPA1L^UAS.cWa, Scer\GAL4^GMR.PU is a suppressor | partially of eye phenotype of Hsap\ATXN3^{CAA.tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU

(Shieh and Bonini, 2011)

Hsap\HSPA1L^UAS.cWa, Scer\GAL4^da.G32 is a suppressor | partially of adult brain | progressive phenotype of Maur\Prp^UAS.cFa, Scer\GAL4^da.G32

(Fernandez-Funez et al., 2009)

Hsap\HSPA1L^UAS.cWa, Scer\GAL4^ey-OK107 is a suppressor | partially of adult mushroom body alpha-lobe | progressive phenotype of Maur\Prp^UAS.cFa, Scer\GAL4^ey-OK107

(Fernandez-Funez et al., 2009)

Hsap\HSPA1L^UAS.cWa, Scer\GAL4^elav-C155 is a suppressor of photoreceptor phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155

(Liévens et al., 2008)

Hsap\HSPA1L^UAS.cWa, Scer\GAL4^elav-C155 is a suppressor of adult mushroom body gamma-lobe phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155

(Liévens et al., 2008)

Hsap\HSPA1L^UAS.cWa, Scer\GAL4^GMR.PU is a suppressor of eye | adult stage phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU

(Liévens et al., 2008)

Hsap\HSPA1L^UAS.cWa, Scer\GAL4^GMR.PF, Scer\GAL80^ts.αTub84B is a suppressor of eye | progressive | heat sensitive phenotype of Hsap\HSPA1L^UAS.cWa, Scer\GAL4^GMR.PF, Scer\GAL80^ts.αTub84B

(Wong et al., 2008)

Hsap\HSPA1L^UAS.cWa, Scer\GAL4^Mhc.PW is a suppressor of wing phenotype of Hsap\PABPN1^17ala.UAS, Scer\GAL4^Mhc.PW

(Chartier et al., 2006)

Hsap\HSPA1L^UAS.cWa, Scer\GAL4^30Y is a suppressor of adult brain phenotype of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^30Y

(Ghosh and Feany, 2004)

Hsap\HSPA1L^UAS.cWa, Scer\GAL4^GMR.PF is a suppressor of retina phenotype of Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF

(Ghosh and Feany, 2004)

Hsap\HSPA1L^UAS.cWa, Scer\GAL4^ChAT.7.4 is a suppressor of adult brain phenotype of Hsap\ATXN1^82.UAS, Scer\GAL4^ChAT.7.4

(Ghosh and Feany, 2004)

Hsap\HSPA1L^UAS.cWa, Scer\GAL4^GMR.PF is a suppressor of retina phenotype of Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA}

(Ghosh and Feany, 2004)

Hsap\HSPA1L^UAS.cWa, Scer\GAL4^GMR.PF is a suppressor of retina phenotype of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF

(Ghosh and Feany, 2004, Bonini, 2002, Warrick et al., 1999)

Hsap\HSPA1L^UAS.cWa, Scer\GAL4^Ddc.PL is a suppressor of dopaminergic neuron phenotype of Hsap\SNCA^UAS.cFa, Scer\GAL4^Ddc.PL

(Auluck et al., 2002)

Hsap\HSPA1L^UAS.cWa/DnaJ-1^UAS.Tag:FLAG, Scer\GAL4^GMR.PF is a suppressor of eye phenotype of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF

(Bonini, 2002)

Hsap\HSPA1L^UAS.cWa, Scer\GAL4^GMR.PF is a suppressor of eye phenotype of Hsap\AR^{Q112.UAS.Tag:HA}, Scer\GAL4^GMR.PF

(Chan et al., 2002)

Scer\GAL4^GMR.PF, Prosβ6^1.UAS/Hsap\HSPA1L^UAS.cWa is a suppressor of eye phenotype of Hsap\AR^{Q112.UAS.Tag:HA}, Scer\GAL4^GMR.PF

(Chan et al., 2002)

Hsap\HSPA1L^UAS.cWa, Scer\GAL4^GMR.PF is a suppressor of eye phenotype of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF

(Bonini, 2002, Warrick et al., 1999)

Scer\GAL4^elav-C155/Hsap\HSPA1L^UAS.cWa is a suppressor of retina | progressive phenotype of Hsap\HTT^GMR.Q120

(Chan et al., 2000)

Scer\GAL4^GMR.PU, Hsap\HSPA1L^UAS.cWa/DnaJ-1^UAS.Tag:FLAG is a suppressor of retina phenotype of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU

(Chan et al., 2000)

NOT Suppressor of

Statement

Reference

Hsap\HSPA1L^UAS.cWa, Scer\GAL4^Appl.G1a is a non-suppressor of mitochondrion | larval stage phenotype of Hsap\SNCA^UAS.EGFP, Scer\GAL4^Appl.G1a

(Krzystek et al., 2021)

Hsap\HSPA1L^UAS.cWa, Scer\GAL4^GMR.PU is a non-suppressor of ommatidium | adult stage phenotype of Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2016)

Hsap\HSPA1L^UAS.cWa, Scer\GAL4^GMR.PU is a non-suppressor of lens phenotype of Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2016)

Hsap\HSPA1L^UAS.cWa, Scer\GAL4^GMR.PU is a non-suppressor of eye disc posterior compartment | larval stage phenotype of Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2016)

Hsap\HSPA1L^UAS.cWa, Scer\GAL4^ey-OK107 is a non-suppressor of axon phenotype of Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^ey-OK107

(Fernandez-Funez et al., 2016)

Hsap\HSPA1L^UAS.cWa, Scer\GAL4^GMR.PU is a non-suppressor of eye phenotype of Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2016)

Hsap\HSPA1L^UAS.cWa, Scer\GAL4^GMR.PF is a non-suppressor of eye phenotype of Hsap\MAPT^V337M.UAS, Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\HSPA1L^UAS.cWa, Scer\GAL4^GMR.PF is a non-suppressor of eye phenotype of Hsap\AR^{Q112.UAS.Tag:HA}, Scer\GAL4^GMR.PF, Uba2^C175S.UAS

(Chan et al., 2002)

Hsap\HSPA1L^UAS.cWa, Scer\GAL4^GMR.PF is a non-suppressor of eye | temperature conditional phenotype of Hsap\AR^{Q112.UAS.Tag:HA}, Scer\GAL4^GMR.PF, Uba2^C175S.UAS

(Chan et al., 2002)

Hsap\HSPA1L^UAS.cWa, Scer\GAL4^GMR.PF is a non-suppressor of ommatidium | temperature conditional phenotype of Hsap\AR^{Q112.UAS.Tag:HA}, Scer\GAL4^GMR.PF, Uba2^C175S.UAS

(Chan et al., 2002)

Hsap\HSPA1L^UAS.cWa, Scer\GAL4^unspecified is a non-suppressor of eye phenotype of Rnor\Map2^UAS.cAa, Scer\GAL4^unspecified

(Warrick et al., 1999)

Other

Statement

Reference

Hsap\APP^2xAPP.SP.UAS, Hsap\HSPA1L^UAS.cWa, Scer\GAL4^ey-OK107 has calyx of adult mushroom body phenotype

(Fernandez-Funez et al., 2016)

Additional Comments

Genetic Interactions

Statement

Reference

Coexpression of the Hsap\HSPA1L^Scer\UAS.cWa transgene, results in efficient suppression of the wing posture phenotype of Scer\GAL4^Mhc.PW>Hsap\PABPN1^{17ala.Scer\UAS} flies.

(Chartier et al., 2006)

Xenogenetic Interactions

Statement

Reference

Co-expression of Hsap\HSPA1L^Scer\UAS.cWa fails to suppress the locomotor defects and reduced lifespan of flies expressing Hsap\APP^{2xAPP.SP.Scer\UAS} under the control of Scer\GAL4^elav.PU.

Co-expression of Hsap\HSPA1L^Scer\UAS.cWa partially suppresses the increased cell death observed in adult Kenyon cells of the mushroom body, and enhances the increased size of the calyx at 1 day old; but expression of Hsap\HSPA1L^Scer\UAS.cWa fails to suppress the thin Kenyon cell axons and the decreased size of the calyx at 20 and 40 days old in flies expressing Hsap\APP^{2xAPP.SP.Scer\UAS} under the control of Scer\GAL4^ey-OK107.

Co-expression of Hsap\HSPA1L^Scer\UAS.cWa fails to suppress the eye phenotypes of adult flies or the increased cell death observed in larval posterior eye discs in flies expressing Hsap\APP^{2xAPP.SP.Scer\UAS} under the control of Scer\GAL4^GMR.PU.

Co-expression of Hsap\HSPA1L^Scer\UAS.cWa completely suppresses the eye phenotypes of flies expressing Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PU.

(Fernandez-Funez et al., 2016)

Expression of Hsap\HSPA1L^Scer\UAS.cWa under the control of Scer\GAL4^ey-OK107 partially suppresses the axon degeneration seen in bsk^flp147E mutant mushroom body neuron clones at 28 days. The number of enlarged and supernumerary axonal protrusions seen on bsk^flp147E mutant axon shafts is also significantly reduced.

Expression of Hsap\HSPA1L^Scer\UAS.cWa partially suppresses the mushroom body degeneration seen in 7 day old flies when Nmnat^JF03337 is expressed under the control of Scer\GAL4^ey-OK107.

(Rallis et al., 2013)

Co-expression of Hsap\HSPA1L^Scer\UAS.cWa strongly suppresses the eye defects caused by expression of Hsap\FUS^{Scer\UAS.cMa.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF at 29[o]C.

Co-expression of Hsap\HSPA1L^Scer\UAS.cWa strongly suppresses the decrease in lifespan caused by expression of Hsap\FUS^{Scer\UAS.cMa.T:Ivir\HA1} under the control of Scer\GAL4^{elav.Switch.PO} in the presence of RU486.

(Miguel et al., 2012)

Co-expression of emb^NIG.13387R enhances the loss of rhabdomere phenotype caused by expression of Hsap\MJD^{fl.Q84.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^GMR.PF. This enhancement is suppressed by co-expression of Hsap\HSPA1L^Scer\UAS.cWa.

(Chan et al., 2011)

Expression of Hsap\HSPA1L^Scer\UAS.cWa partially suppresses the eye pigmentation phenotype seen in 15 day old adults when Hsap\TARDBP^{Scer\UAS.T:Avic\GFP-YFP.cEa} is expressed under the control of Scer\GAL4^D42 at 25[o]C.

Expression of Hsap\HSPA1L^Scer\UAS.cWa partially suppresses the eye pigmentation phenotype seen in 15 day old adults when Hsap\TARDBP^{A315T.Scer\UAS.T:Avic\GFP-YFP} is expressed under the control of Scer\GAL4^D42 at 25[o]C.

(Estes et al., 2011)

Expression of Hsap\HSPA1L^Scer\UAS.cWa suppresses the climbing defects seen when Disc\RFP^{CAG250.DsRed2.Scer\UAS} is expressed under the control of Scer\GAL4^da.PU.

Expression of Hsap\HSPA1L^Scer\UAS.cWa partially suppresses the wing posture and climbing defects seen when Disc\RFP^{CAG250.DsRed2.Scer\UAS} is expressed under the control of Scer\GAL4^da.PU.

(Shieh and Bonini, 2011)

30 day old Maur\Prp^Scer\UAS.cFa Scer\GAL4^da.G32 fly brains co-expressing Hsap\HSPA1L^Scer\UAS.cWa exhibit very few vacuolated cells and normal nuclei.

40 day old Maur\Prp^Scer\UAS.cFa Scer\GAL4^ey-OK107 fly brains co-expressing Hsap\HSPA1L^Scer\UAS.cWa demonstrate robust protection of mushroom body projections.

Co-expression of Hsap\HSPA1L^Scer\UAS.cWa reduces the decline in climbing ability seen in Maur\Prp^Scer\UAS.cFa Scer\GAL4^Act.PU flies.

Co-expression of Hsap\HSPA1L^Scer\UAS.cWa suppresses the reduced distribution and speed seen in 20 day old Maur\Prp^Scer\UAS.cFa Scer\GAL4^Act.PU flies when tracked in a custom arena.

(Fernandez-Funez et al., 2009)

Expression of Hsap\HSPA1L^Scer\UAS.cWa suppresses the pigment cell degeneration seen when Hsap\HTT^{Q93.ex1p.Scer\UAS} is expressed under the control of Scer\GAL4^GMR.PU.

Expression of Hsap\HSPA1L^Scer\UAS.cWa significantly delays the progressive photoreceptor degeneration seen when Hsap\HTT^{Q93.ex1p.Scer\UAS} is expressed under the control of Scer\GAL4^elav-C155.

Expression of Hsap\HSPA1L^Scer\UAS.cWa partially suppresses the reduction in life expectancy seen when Hsap\HTT^{Q93.ex1p.Scer\UAS} is expressed under the control of any of Scer\GAL4^elav-C155, Scer\GAL4^repo.PU or Scer\GAL4^Eaat1.PR.

Expression of Hsap\HSPA1L^Scer\UAS.cWa suppresses the γ-lobe kenyon cell degeneration seen in the mushroom bodies when Hsap\HTT^{Q93.ex1p.Scer\UAS} is expressed under the control of Scer\GAL4^elav-C155.

Expression of Hsap\HSPA1L^Scer\UAS.cWa partially suppresses the locomotor defects seen when Hsap\HTT^{Q93.ex1p.Scer\UAS} is expressed under the control of either Scer\GAL4^elav-C155 or Scer\GAL4^repo.PU.

(Liévens et al., 2008)

The lethality of trpml¹ homozygotes and the locomotor defects of trpml¹ homozygous adult escapers is suppressed by expression of Hsap\HSPA1L^Scer\UAS.cWa under the control of either Scer\GAL4^Act5C.PI or Scer\GAL4^elav-C155.

(Venkatachalam et al., 2008)

Co-expression of Hsap\HSPA1L^Scer\UAS.cWa can suppress neurodegeneration induced by Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}.

(Wong et al., 2008)

The progressive degeneration and pigmentation loss eye phenotype characteristic for flies expressing Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PU is suppressed by co-expression of Hsap\HSPA1L^Scer\UAS.cWa although signs of degeneration are eventually observed in aged (32 days post-eclosion) flies.

(Huen and Chan, 2005)

The rough eye phenotype caused by expression of Hsap\MAPT^{V337M.Scer\UAS} under the control of Scer\GAL4^GMR.PF is not modified if the flies are also carrying Hsap\HSPA1L^Scer\UAS.cWa.

(Shulman and Feany, 2003)

The loss of dorsomedial dopaminergic neurons seen in 20 day old flies expressing Hsap\SNCA^Scer\UAS.cFa under the control of Scer\GAL4^Ddc.PL is suppressed by co-expression of Hsap\HSPA1L^Scer\UAS.cWa, although there is no change in the number, morphology or distribution of inclusions seen in the dopaminergic neurons.

(Auluck et al., 2002)

Co-expression of Hsap\HSPA1L^Scer\UAS.cWa partially suppresses the eye degeneration seen in flies expressing Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF.

Co-expression of both Hsap\HSPA1L^Scer\UAS.cWa and DnaJ-1^{Scer\UAS.T:Zzzz\FLAG} completely suppresses the eye degeneration seen in flies expressing Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF.

(Bonini, 2002)

Co-expression of Hsap\HSPA1L^Scer\UAS.cWa with Hsap\AR^{Q112.Scer\UAS.T:Ivir\HA1} in the eye (under the control of Scer\GAL4^GMR.PF suppresses the external and internal eye phenotypes associated with Hsap\AR^{Q112.Scer\UAS.T:Ivir\HA1}.

Co-expression of Uba2^{C175S.Scer\UAS} and Hsap\HSPA1L^Scer\UAS.cWa with Hsap\AR^{Q112.Scer\UAS.T:Ivir\HA1} (all under the control of Scer\GAL4^GMR.PF) fails to suppress the enhancement of the eye degeneration phenotype found in Uba2^{C175S.Scer\UAS} ; Hsap\AR^{Q112.Scer\UAS.T:Ivir\HA1} flies.

Co-expression of Pros26^1.Scer\UAS and Hsap\HSPA1L^Scer\UAS.cWa, together with the pathogenic Hsap\AR^{Q112.Scer\UAS.T:Ivir\HA1} lines (all under the control of the Scer\GAL4^GMR.PF driver) suppress the eye phenotype.

(Chan et al., 2002)

Expression of Hsap\HSPA1L^Scer\UAS.cWa under the control of Scer\GAL4^elav-C155 restores eye structure in 10 day old flies expressing Hsap\HTT^GMR.Q120, such that photoreceptor neurons appear normal.

Flies that co-express Hsap\HSPA1L^Scer\UAS.cWa, Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} and DnaJ-1^{ΔJ.Scer\UAS.T:Zzzz\FLAG} under the control of Scer\GAL4^GMR.PU have normal eyes.

Co-expression of Hsap\HSPA1L^Scer\UAS.cWa partially suppresses the retinal degeneration seen in flies expressing Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PU.

Simultaneous co-expression of both DnaJ-1^{Scer\UAS.T:Zzzz\FLAG} and Hsap\HSPA1L^Scer\UAS.cWa results in a stronger suppression of the retinal degeneration caused by expression of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PU than expression of either construct alone.

(Chan et al., 2000)

Suppresses the eye phenotype caused by expression of Hsap\MJD^{Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF. Does not modify the disrupted eye phenotype caused by expression of ey^Scer\UAS.cHa or Rnor\MAP2^Scer\UAS.cAa under the control of Scer\GAL4^unspecified.

(Warrick et al., 1999)

Complementation and Rescue Data

Comments

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Mutant

Wild-type

Stocks (2)

Bloomington

7454

w¹¹¹⁸; P{UAS-Hsap\HSPA1L.W}41.1

7455

w¹¹¹⁸; P{UAS-Hsap\HSPA1L.W}53.1/CyO

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Hsap\HSPA1L^Scer\UAS.cWa

Hsap\HSPA1L^UAS.cWa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Warrick

(Warrick et al., 1999)

Secondary FlyBase IDs

References (40)

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